Department of Immunoregulation

Staff:

Professor(SUP)

Taroh Kinoshita, Ph.D.

Associate Professor

Yusuke Maeda, M.D., Ph.D.

Associate Professor(SUP)

Yoshiko Murakami, M.D., Ph.D.

Assistant Professor

Yuko Tashima, Ph.D.

Specially Appointed Assistant Professor

Noriyuki Kanzawa, Ph.D.

Specially Appointed Researcher(SUP)

Chandan Mandal, Ph.D.

Specially Appointed Researcher

Tetsuya Hirata, Ph.D.

Visiting Academic Staff

Shogo Murata, M.D., Ph.D.

Graduate Student

Gun Hee Lee

Yicheng Wang

Research Student

Keiko Kinoshita

Subjects:

1. Biochemistry and molecular biology of biosynthesis pathway of GPI-anchored proteins.
2. Molecular pathogenesis of a GPI-anchor deficiencies, paroxysmal nocturnal hemoglobinuria and inherited GPI deficiency.
3. pH regulation and its biological significance in acidic organelles.

Papers published in 2016

1. Lipoarabinomannan binding to lactosylceramide in lipid rafts is essential for the phagocytosis of mycobacteria by human neutrophils.

   Hitoshi Nakayama, Hidetake Kurihara, Yasu S Morita, Taroh Kinoshita, Laura Mauri, Alessandro Prinetti, Sandro Sonnino, Noriko Yokoyama, Hideoki Ogawa, Kenji Takamori and Kazuhisa Iwabuchi

   Sci Signal, 9 (449), ra101, 2016.
2. A GPI processing phospholipase A2, PGAP6, modulates Nodal signaling in embryos by shedding CRIPTO.

   Gun-Hee Lee, Morihisa Fujita, Katsuyoshi Takaoka, Yoshiko Murakami, Yoshitaka Fujihara, Noriyuki Kanzawa, Kei-Ichi Murakami, Eriko Kajikawa, Yoko Takada, Kazunobu Saito, Masahito Ikawa, Hiroshi Hamada, Yusuke Maeda and Taroh Kinoshita

   J Cell Biol, 215 (5), 705-718, 2016.
3. Pathogenic Variants in PIGG Cause Intellectual Disability with Seizures and Hypotonia.

   Periklis Makrythanasis, Mitsuhiro Kato, Maha S Zaki, Hirotomo Saitsu, Kazuyuki Nakamura, Federico A Santoni, Satoko Miyatake, Mitsuko Nakashima, Mahmoud Y Issa, Michel Guipponi, Audrey Letourneau, Clare V Logan, Nicola Roberts, David A Parry, Colin A Johnson, Naomichi Matsumoto, Hanan Hamamy, Eamonn Sheridan, Taroh Kinoshita, Stylianos E Antonarakis and Yoshiko Murakami

   Am J Hum Genet, 98 (4), 615-626, 2016.
4. Spatially distinct and metabolically active membrane domain in mycobacteria.

   Jennifer M Hayashi, Chu-Yuan Luo, Jacob A Mayfield, Tsungda Hsu, Takeshi Fukuda, Andrew L Walfield, Samantha R Giffen, John D Leszyk, Christina E Baer, Owen T Bennion, Ashoka Madduri, Scott A Shaffer, Bree B Aldridge, Christopher M Sassetti, Steven J Sandler, Taroh Kinoshita, D Branch Moody and Yasu S Morita

   Proc Natl Acad Sci U S A, 113 (19), 5400-5405, 2016.
5. Rare Noncoding Mutations Extend the Mutational Spectrum in the PGAP3 Subtype of Hyperphosphatasia with Mental Retardation Syndrome.

   Alexej Knaus, Tomonari Awaya, Ingo Helbig, Zaid Afawi, Manuela Pendziwiat, Jubran Abu-Rachma, Miles D Thompson, David E Cole, Steve Skinner, Fran Annese, Natalie Canham, Michal R Schweiger, Peter N Robinson, Stefan Mundlos, Taroh Kinoshita, Arnold Munnich, Yoshiko Murakami, Denise Horn and Peter M Krawitz

   Hum Mutat, 37 (8), 737-744, 2016.
6. Interim analysis of post-marketing surveillance of eculizumab for paroxysmal nocturnal hemoglobinuria in Japan.

   Haruhiko Ninomiya, Naoshi Obara, Shigeru Chiba, Kensuke Usuki, Kaichi Nishiwaki, Itaru Matsumura, Tsutomu Shichishima, Shinichiro Okamoto, Jun-Ichi Nishimura, Kazuma Ohyashiki, Shinji Nakao, Kiyoshi Ando, Yoshinobu Kanda, Tatsuya Kawaguchi, Hideki Nakakuma, Daisuke Harada, Hirozumi Akiyama, Taroh Kinoshita, Keiya Ozawa, Mitsuhiro Omine and Yuzuru Kanakura

   Int J Hematol, 104 (5), 548-558, 2016.
7. 3D Structure and Interaction of p24β and p24δ Golgi Dynamics Domains: Implication for p24 Complex Formation and Cargo Transport.

   Masamichi Nagae, Tetsuya Hirata, Kana Morita-Matsumoto, Romina Theiler, Morihisa Fujita, Taroh Kinoshita and Yoshiki Yamaguchi

   J Mol Biol, 428 (20), 4087-4099, 2016.
8. A novel mutation in PIGW causes glycosylphosphatidylinositol deficiency without hyperphosphatasia.

   Max Hogrebe, Yoshiko Murakami, Martin Wild, Martina Ahlmann, Saskia Biskup, Konstanze Hörtnagel, Marianne Grüneberg, Janine Reunert, Tobias Linden, Taroh Kinoshita and Thorsten Marquardt

   Am J Med Genet A, 170 (12), 3319-3322, 2016.
9. Biosynthesis of GPI-anchored proteins: special emphasis on GPI lipid remodeling.

   Taroh Kinoshita and Morihisa Fujita

   J Lipid Res, 57 (1), 6-24, 2016.
10. Glycosylphosphatidylinositol (GPI) Anchors: Biochemistry and Cell Biology: Introduction to a Thematic Review Series.

    Taroh Kinoshita

    J Lipid Res, 57 (1), 4-5, 2016.
11. CCDC115 Deficiency Causes a Disorder of Golgi Homeostasis with Abnormal Protein Glycosylation.

    Jos C Jansen, Sebahattin Cirak, Monique van Scherpenzeel, Sharita Timal, Janine Reunert, Stephan Rust, Belén Pérez, Dorothée Vicogne, Peter Krawitz, Yoshinao Wada, Angel Ashikov, Celia Pérez-Cerdá, Celia Medrano, Andrea Arnoldy, Alexander Hoischen, Karin Huijben, Gerry Steenbergen, Dulce Quelhas, Luisa Diogo, Daisy Rymen, Jaak Jaeken, Nathalie Guffon, David Cheillan, Lambertus P van den Heuvel, Yusuke Maeda, Olaf Kaiser, Ulrike Schara, Patrick Gerner, Marjolein A W van den Boogert, Adriaan G Holleboom, Marie-Cécile Nassogne, Etienne Sokal, Jody Salomon, Geert van den Bogaart, Joost P H Drenth, Martijn A Huynen, Joris A Veltman, Ron A Wevers, Eva Morava, Gert Matthijs, François Foulquier, Thorsten Marquardt and Dirk J Lefeber

    Am J Hum Genet, 98 (2), 310-321, 2016.
12. A novel PIGN mutation and prenatal diagnosis of inherited glycosylphosphatidylinositol deficiency.

    Taku Nakagawa, Mariko Taniguchi-Ikeda, Yoshiko Murakami, Shota Nakamura, Daisuke Motooka, Tomomi Emoto, Wataru Satake, Masahiro Nishiyama, Daisaku Toyoshima, Naoya Morisada, Satoshi Takada, Shinya Tairaku, Nobuhiko Okamoto, Ichiro Morioka, Hiroki Kurahashi, Tatsushi Toda, Taroh Kinoshita and Kazumoto Iijima

    Am J Med Genet A, 170 (1), 183-188, 2016.

Link

Department of Immunoregulation

Research Institute for Microbial Diseases, Osaka University