Department of Host Defense

Staff:

Professor(SUP)

Shizuo Akira, M.D., Ph.D.

Associate Professor

Kazuhiko Maeda, Ph.D.

Assistant Professor

Takashi Satoh, Ph.D.

Specially Appointed Assistant Professor(SUP)

Kenta Maruyama, M.D., Ph.D.

Guest Associate Professor

Mikael Martino, Ph.D.

Specially Appointed Researcher

Hiroki Tanaka, Ph.D.

Kanako Kuniyoshi, Ph.D.

Shailendra Kumar Singh, Ph.D.

Joint Research Collaborator

Isao Ebina

Yasuharu Nagahama, Ph.D.

Yuuki Kozakai, Ph.D.

Hiroshi Nabeshima

Graduate Student

Guoliang Mao

Liang Zhao

Fumihiro Yamane

Hisashi Kanemaru, M.D.

Kiyoharu Fukushima, M.D.

Takanori Matsuki, M.D.

Reiko Mishima

Xin Sun

Mayuko Shimoda

Takahiro Kawasaki, M.D.

Under Graduate Student

Noriyuki Miyamoto

Ryo Takenaka

Taichi Kidani

Soichiro Saeki

Subjects:

1. Analysis of innate immune response mediated by pattern-recognition receptor family
2. Analysis of disorder-specific macrophage subtype
3. Analysis of mRNA stability systems

Papers published in 2016

1. Genome-wide map of RNA degradation kinetics patterns in dendritic cells after LPS stimulation facilitates identification of primary sequence and secondary structure motifs in mRNAs.

   Yutaro Kumagai, Alexis Vandenbon, Shunsuke Teraguchi, Shizuo Akira and Yutaka Suzuki

   BMC Genomics, 17 (Suppl 13), 1032, 2016.
2. Toll-Like Receptor Signaling and Its Inducible Proteins.

   Takashi Satoh and Shizuo Akira

   Microbiol Spectr, 4 (6), MCHD-0040-2016, 2016.
3. Toll-like receptor 9 prevents cardiac rupture after myocardial infarction in mice independently of inflammation.

   Shigemiki Omiya, Yosuke Omori, Manabu Taneike, Andrea Protti, Osamu Yamaguchi, Shizuo Akira, Ajay M Shah, Kazuhiko Nishida and Kinya Otsu

   Am J Physiol Heart Circ Physiol, 311 (6), H1485-H1497, 2016.
4. TLR7 Structure: Cut in Z-Loop.

   Kazuhiko Maeda and Shizuo Akira

   Immunity, 45 (4), 705-707, 2016.
5. Pillars Article: Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the Lps Gene Product. J. Immunol. 1999. 162: 3749-3752.

   Katsuaki Hoshino, Osamu Takeuchi, Taro Kawai, Hideki Sanjo, Tomohiko Ogawa, Yoshifumi Takeda, Kiyoshi Takeda and Shizuo Akira

   J Immunol, 197 (7), 2563-2566, 2016.
6. Bone-protective Functions of Netrin 1 Protein.

   Kenta Maruyama, Takahiko Kawasaki, Masahide Hamaguchi, Motomu Hashimoto, Moritoshi Furu, Hiromu Ito, Takao Fujii, Naoki Takemura, Thangaraj Karuppuchamy, Takeshi Kondo, Takumi Kawasaki, Masahiro Fukasaka, Takuma Misawa, Tatsuya Saitoh, Yutaka Suzuki, Mikaël M Martino, Yutaro Kumagai and Shizuo Akira

   J Biol Chem, 291 (46), 23854-23868, 2016.
7. The Tbr2 Molecular Network Controls Cortical Neuronal Differentiation Through Complementary Genetic and Epigenetic Pathways.

   Alessandro Sessa, Ernesto Ciabatti, Daniela Drechsel, Luca Massimino, Gaia Colasante, Serena Giannelli, Takashi Satoh, Shizuo Akira, Francois Guillemot and Broccoli Vania

   Cereb Cortex, , , 2016.
8. Impaired autophagy in macrophages promotes inflammatory eye disease.

   Andrea Santeford, Luke A Wiley, Sunmin Park, Sonya Bamba, Rei Nakamura, Abdelaziz Gdoura, Thomas A Ferguson, P Kumar Rao, Jun-Lin Guan, Tatsuya Saitoh, Shizuo Akira, Ramnik Xavier, Herbert W Virgin and Rajendra S Apte

   Autophagy, 12 (10), 1876-1885, 2016.
9. Regulation of inflammasomes by autophagy.

   Tatsuya Saitoh and Shizuo Akira

   J Allergy Clin Immunol, 138 (1), 28-36, 2016.
10. Sepsis-Induced Osteoblast Ablation Causes Immunodeficiency.

    Asuka Terashima, Kazuo Okamoto, Tomoki Nakashima, Shizuo Akira, Koichi Ikuta and Hiroshi Takayanagi

    Immunity, 44 (6), 1434-1443, 2016.
11. Structural analysis of the activation-induced deoxycytidine deaminase required in immunoglobulin diversification.

    Phuong Pham, Samir A Afif, Mayuko Shimoda, Kazuhiko Maeda, Nobuo Sakaguchi, Lars C Pedersen and Myron F Goodman

    DNA Repair (Amst), 43, 48-56, 2016.
12. Raman spectroscopy as a tool for label-free lymphocyte cell line discrimination.

    Alison J Hobro, Yutaro Kumagai, Shizuo Akira and Nicholas I Smith

    Analyst, 141 (12), 3756-3764, 2016.
13. Cancer therapies activate RIG-I-like receptor pathway through endogenous non-coding RNAs.

    Diana Rose E Ranoa, Akash D Parekh, Sean P Pitroda, Xiaona Huang, Thomas Darga, Anthony C Wong, Lei Huang, Jorge Andrade, Jonathan P Staley, Takashi Satoh, Shizuo Akira, Ralph R Weichselbaum and Nikolai N Khodarev

    Oncotarget, 7 (18), 26496-26515, 2016.
14. Germinal Center B-Cell-Associated Nuclear Protein (GANP) Involved in RNA Metabolism for B Cell Maturation.

    N Sakaguchi and K Maeda

    Adv Immunol, 131, 135-186, 2016.
15. Inhibition of IL-1R1/MyD88 signalling promotes mesenchymal stem cell-driven tissue regeneration.

    Mikaël M Martino, Kenta Maruyama, Gisela A Kuhn, Takashi Satoh, Osamu Takeuchi, Ralph Müller and Shizuo Akira

    Nat Commun, 7, 11051, 2016.
16. Creation of chimeric human/rabbit APOBEC1 with HIV-1 restriction and DNA mutation activities.

    Terumasa Ikeda, Eugene Boon Beng Ong, Nobumoto Watanabe, Nobuo Sakaguchi, Kazuhiko Maeda and Atsushi Koito

    Sci Rep, 6, 19035, 2016.
17. Structural basis for the regulation of enzymatic activity of Regnase-1 by domain-domain interactions.

    Mariko Yokogawa, Takashi Tsushima, Nobuo N Noda, Hiroyuki Kumeta, Yoshiaki Enokizono, Kazuo Yamashita, Daron M Standley, Osamu Takeuchi, Shizuo Akira and Fuyuhiko Inagaki

    Sci Rep, 6, 22324, 2016.
18. Autophagy Genes Enhance Murine Gammaherpesvirus 68 Reactivation from Latency by Preventing Virus-Induced Systemic Inflammation.

    Sunmin Park, Michael D Buck, Chandni Desai, Xin Zhang, Ekaterina Loginicheva, Jennifer Martinez, Michael L Freeman, Tatsuya Saitoh, Shizuo Akira, Jun-Lin Guan, You-Wen He, Marcia A Blackman, Scott A Handley, Beth Levine, Douglas R Green, Tiffany A Reese, Maxim N Artyomov and Herbert W Virgin

    Cell Host Microbe, 19 (1), 91-101, 2016.
19. TANK-binding kinase 1-dependent or -independent signaling elicits the cell-type-specific innate immune responses induced by the adenovirus vector.

    Sayaka Tsuzuki, Masashi Tachibana, Masahisa Hemmi, Tomoko Yamaguchi, Masaki Shoji, Fuminori Sakurai, Kouji Kobiyama, Kenji Kawabata, Ken J Ishii, Shizuo Akira and Hiroyuki Mizuguchi

    Int Immunol, 28 (3), 105-115, 2016.

Link

Department of Host Defense

Research Institute for Microbial Diseases, Osaka University