Department of Celluar Regulation

Staff:

Professor

Hiroaki Miki, Ph.D.

Guest Professor

Shiro Suetsugu, Ph.D.

Assistant Professor

Daisuke Yamazaki, Ph.D.

Yosuke Funato, Ph.D.

Visiting Researcher

Kyoko Hanawa, Ph.D.

Specially Appointed Researcher

Osamu Hashizume, Ph.D.

Graduate Student

Kaori Shibuya

Minami Suzuki

Akiko Tateishi

Hiroki Mitani

Sweksha Lohani

Undergraduate Student

Ayaka Hasegawa

Mai Mimura

Atsushi Yoshida

1. Mechanism of cancer progression by suppressing magnesium transport
2. Analysis of sperm dysfunction caused by CNNM-knockout
3. Regulation of the PRL-CNNM interaction by Cys phosphorylation
4. Analysis of signal transduction regulated by Mg2+ using C. elegans
5. Regulation of blood pressure by renal reabsorption by Mg2+

Papers published in 2016

1. Phosphocysteine in the PRL-CNNM pathway mediates magnesium homeostasis.

   Irina Gulerez, Yosuke Funato, Howie Wu, Meng Yang, Guennadi Kozlov, Hiroaki Miki and Kalle Gehring

   EMBO Rep, 17 (12), 1890-1900, 2016.
2. Complementary role of CNNM2 in sperm motility and Ca(2+) influx during capacitation.

   Daisuke Yamazaki, Yosuke Funato, Haruhiko Miyata, Masahito Ikawa and Hiroaki Miki

   Biochem Biophys Res Commun, 474 (3), 441-446, 2016.
3. Mg2+ Extrusion from Intestinal Epithelia by CNNM Proteins Is Essential for Gonadogenesis via AMPK-TORC1 Signaling in Caenorhabditis elegans.

   Tasuku Ishii, Yosuke Funato, Osamu Hashizume, Daisuke Yamazaki, Yusuke Hirata, Kiyoji Nishiwaki, Nozomu Kono, Hiroyuki Arai and Hiroaki Miki

   PLoS Genet, 12 (8), e1006276, 2016.
4. The Mg2+ transporter CNNM4 regulates sperm Ca2+ homeostasis and is essential for reproduction.

   Daisuke Yamazaki, Haruhiko Miyata, Yosuke Funato, Yoshitaka Fujihara, Masahito Ikawa and Hiroaki Miki

   J Cell Sci, 129 (9), 1940-1949, 2016.

Link

Department of Cellular Regulation

Research Institute for Microbial Diseases, Osaka University