Vaccine Dynamics Project, BIKEN Innovative Vaccine Research Alliance Laboratories

Staff:

Specially Appointed Associate Professor

Taiki Aoshi, M.D., Ph.D

Subjects:

1. Identification of new T cell epitopes for diseases including infection, autoimmunity, and cancer.
2. Understanding of antigen presenting cells/CD4T/CD8T cell interactions and their effects on T cell response induction.
3. Development of clinically applicable new A/D type CpG ODNs.

Papers published in 2015

1. 2015 Guidance on cancer immunotherapy development in early-phase clinical studies.

   et al.

   Cancer Sci, 106 (12), 1761-1771, 2015.
2. Development of Nonaggregating Poly-A Tailed Immunostimulatory A/D Type CpG Oligodeoxynucleotides Applicable for Clinical Use.

   Taiki Aoshi, Yasunari Haseda, Kouji Kobiyama, Hirotaka Narita, Hideaki Sato, Hirokazu Nankai, Shinichi Mochizuki, Kazuo Sakurai, Yuko Katakai, Yasuhiro Yasutomi, Etsushi Kuroda, Cevayir Coban and Ken J Ishii

   J Immunol Res, 2015, 316364, 2015.
3. Immunization with antigenic peptides complexed with β-glucan induces potent cytotoxic T-lymphocyte activity in combination with CpG-ODNs.

   Shinichi Mochizuki, Hiromi Morishita, Kouji Kobiyama, Taiki Aoshi, Ken J Ishii and Kazuo Sakurai

   J Control Release, 220 (Pt A), 495-502, 2015.

Link

Lab HP

Research Institute for Microbial Diseases, Osaka University