Vaccine Creation Project, BIKEN Innovative Vaccine Research Alliance Laboratories

Staff:

Specially Appointed Associate Professor

Yasuo Yoshioka, Ph.D.

Specially Appointed Researcher

Hideki Takahashi

Kazuki Misato

Subjects:

1. Development of vaccine adjuvant using comprehensive screening methods
2. Development of antigen delivery carriers and adjuvants using nanotechnology
3. Development of vaccines for infectious diseases using our developed adjuvants and delivery carriers

Papers published in 2015

1. Protein corona changes mediated by surface modification of amorphous silica nanoparticles suppress acute toxicity and activation of intrinsic coagulation cascade in mice.

   Tokuyuki Yoshida, Yasuo Yoshioka, Yuki Morishita, Michihiko Aoyama, Saeko Tochigi, Toshiro Hirai, Kota Tanaka, Kazuya Nagano, Haruhiko Kamada, Shin-ichi Tsunoda, Hiromi Nabeshi, Tomoaki Yoshikawa, Kazuma Higashisaka and Yasuo Tsutsumi

   Nanotechnology, 26 (24), 245101, 2015.
2. Cutaneous exposure to agglomerates of silica nanoparticles and allergen results in IgE-biased immune response and increased sensitivity to anaphylaxis in mice.

   Toshiro Hirai, Yasuo Yoshioka, Hideki Takahashi, Ko-ichi Ichihashi, Asako Udaka, Takahide Mori, Nobuo Nishijima, Tokuyuki Yoshida, Kazuya Nagano, Haruhiko Kamada, Shin-ichi Tsunoda, Tatsuya Takagi, Ken J Ishii, Hiromi Nabeshi, Tomoaki Yoshikawa, Kazuma Higashisaka and Yasuo Tsutsumi

   Part Fibre Toxicol, 12, 16, 2015.
3. Hydroxylated fullerene: a potential antiinflammatory and antioxidant agent for preventing mouse preterm birth.

   Tetsu Wakimoto, Kaoru Uchida, Kazuya Mimura, Takeshi Kanagawa, Tzvetozar Roussev Mehandjiev, Hisae Aoshima, Ken Kokubo, Nobuaki Mitsuda, Yasuo Yoshioka, Yasuo Tsutsumi, Tadashi Kimura and Itaru Yanagihara

   Am J Obstet Gynecol, 213 (5), 708.e1-9, 2015.
4. Applications and safety of nanomaterials used in the food industry

   Kazuma Higashisaka, Yasuo Yoshioka and Yasuo Tsutsumi

   Food Safety, 3 (2), 39-47, 2015.

Link

Research Institute for Microbial Diseases, Osaka University