Department of Signal Transduction

Staff:

Professor

Nobuyuki Takakura, M.D., Ph.D.

Assistant Professor

Hiroyasu Kidoya, Ph.D.

Hisamichi Naito, M.D., Ph.D.

Specially Appointed Researcher

Yinglu Han, Ph.D.

Daishi Yamakawa, Ph.D.

Weizhen Jia, Ph.D.

Taku Wakabayashi, M.D., Ph.D.

Chie Takeshita

Graduate Student

Kazuhiro Takara

Hiroki Kawahara

Gong Zhiyuan

Zhang Li

Ryu Kanzaki

Fumitaka Muramatsu

Keitaro Yamane

Tomoko Kosaka

Hironori Yoshida

Daisuku Eino

Miku Kitta

Yumiko Hayashi

Shoko Hosojima

Research Student

Nobuaki Ooto

Subjects:

1. Elucidation of the tube-forming mechanism by investigating the polarity of ECs.
2. Analysis of the functional role(s) of Tie2 and down stream of Tie2 in the maturation of blood vessels.
3. Analysis of hematopoietic cells in angiogenesis.
4. Analysis of specification between artery and vein.
5. Analysis of stem cell system in blood vessels.
6. Functional analysis of GINS complex and galectin-3 in stem cells.

Papers published in 2015

1. Arf6 regulates tumour angiogenesis and growth through HGF-induced endothelial β1 integrin recycling.

   Tsunaki Hongu, Yuji Funakoshi, Shigetomo Fukuhara, Teruhiko Suzuki, Susumu Sakimoto, Nobuyuki Takakura, Masatsugu Ema, Satoru Takahashi, Susumu Itoh, Mitsuyasu Kato, Hiroshi Hasegawa, Naoki Mochizuki and Yasunori Kanaho

   Nat Commun, 6, 7925, 2015.
2. Atrial natriuretic peptide prevents cancer metastasis through vascular endothelial cells.

   Takashi Nojiri, Hiroshi Hosoda, Takeshi Tokudome, Koichi Miura, Shin Ishikane, Kentaro Otani, Ichiro Kishimoto, Yasushi Shintani, Masayoshi Inoue, Toru Kimura, Noriyoshi Sawabata, Masato Minami, Tomoyuki Nakagiri, Soichiro Funaki, Yukiyasu Takeuchi, Hajime Maeda, Hiroyasu Kidoya, Hiroshi Kiyonari, Go Shioi, Yuji Arai, Takeshi Hasegawa, Nobuyuki Takakura, Megumi Hori, Yuko Ohno, Mikiya Miyazato, Naoki Mochizuki, Meinoshin Okumura and Kenji Kangawa

   Proc Natl Acad Sci U S A, 112 (13), 4086-4091, 2015.
3. Murine hematopoietic stem cell dormancy controlled by induction of a novel short form of PSF1 by histone deacetylase inhibitors.

   Yinglu Han, Zhi-Yuan Gong and Nobuyuki Takakura

   Exp Cell Res, 334 (2), 183-193, 2015.
4. APJ Regulates Parallel Alignment of Arteries and Veins in the Skin.

   Hiroyasu Kidoya, Hisamichi Naito, Fumitaka Muramatsu, Daishi Yamakawa, Weizhen Jia, Masahito Ikawa, Takashi Sonobe, Hirotsugu Tsuchimochi, Mikiyasu Shirai, Ralf H Adams, Akiyoshi Fukamizu and Nobuyuki Takakura

   Dev Cell, 33 (3), 247-259, 2015.
5. Cell-sheet Therapy With Omentopexy Promotes Arteriogenesis and Improves Coronary Circulation Physiology in Failing Heart.

   Satoshi Kainuma, Shigeru Miyagawa, Satsuki Fukushima, James Pearson, Yi Ching Chen, Atsuhiro Saito, Akima Harada, Motoko Shiozaki, Hiroko Iseoka, Tadashi Watabe, Hiroshi Watabe, Genki Horitsugi, Mana Ishibashi, Hayato Ikeda, Hirotsugu Tsuchimochi, Takashi Sonobe, Yutaka Fujii, Hisamichi Naito, Keiji Umetani, Tatsuya Shimizu, Teruo Okano, Eiji Kobayashi, Takashi Daimon, Takayoshi Ueno, Toru Kuratani, Koichi Toda, Nobuyuki Takakura, Jun Hatazawa, Mikiyasu Shirai and Yoshiki Sawa

   Mol Ther, 23 (2), 374-386, 2015.
6. Evaluation of PSF1 as a prognostic biomarker for prostate cancer.

   H Tahara, H Naito, K Kise, T Wakabayashi, K Kamoi, K Okihara, A Yanagisawa, Y Nakai, N Nonomura, E Morii, T Miki and N Takakura

   Prostate Cancer Prostatic Dis, 18 (1), 56-62, 2015.

Link

Department of Signal Transduction

Research Institute for Microbial Diseases, Osaka University