Department of Molecular Genetics

Staff:

Professor

Hiroshi Nojima, Ph.D.

Associate Professor

Norikazu Yabuta, Ph.D.

Assistant Professor (SUP)

Daisuke Okuzaki, Ph.D.

Specially Appointed Researcher

Satomi Mukai, Ph.D.

Researcher

Yuki Sekine

Research Collaborator

Daisaku Miura, Ph.D.

Graduate Student

Kosuke Torigata

Katsuma Matsuura

Wang Mian

Kaori Ota

Chie Ota

Yorika Kato

Subjects:

1. Molecular mechanisms regulating the cell cycle (checkpoint) in mammalian cells.
2. Molecular mechanisms modulating the malignancy of cancer cells.
3. Application of a new technique (Leuko Catch) to RNA diagnosis.

Papers published in 2015

1. Influenza A Virus-Induced Expression of a GalNAc Transferase, GALNT3, via MicroRNAs Is Required for Enhanced Viral Replication.

   Shoko Nakamura, Masayuki Horie, Tomo Daidoji, Tomoyuki Honda, Mayo Yasugi, Atsushi Kuno, Toshihisa Komori, Daisuke Okuzaki, Hisashi Narimatsu, Takaaki Nakaya and Keizo Tomonaga

   J Virol, 90 (4), 1788-1801, 2015.
2. Cyclin G2: A novel independent prognostic marker in pancreatic cancer.

   Shinichiro Hasegawa, Hiroaki Nagano, Masamitsu Konno, Hidetoshi Eguchi, Akira Tomokuni, Yoshito Tomimaru, Hiroshi Wada, Naoki Hama, Koichi Kawamoto, Shogo Kobayashi, Shigeru Marubashi, Naohiro Nishida, Jun Koseki, Noriko Gotoh, Shouichi Ohno, Norikazu Yabuta, Hiroshi Nojima, Masaki Mori, Yuichiro Doki and Hideshi Ishii

   Oncol Lett, 10 (5), 2986-2990, 2015.
3. Lats1 suppresses centrosome overduplication by modulating the stability of Cdc25B.

   Satomi Mukai, Norikazu Yabuta, Kaori Yoshida, Ayumi Okamoto, Daisaku Miura, Yasuhide Furuta, Takaya Abe and Hiroshi Nojima

   Sci Rep, 5, 16173, 2015.
4. Effects of low-fat diet and aging on metabolic profiles of Creb3l4 knockout mice.

   T-H Kim, J-M Park, S-H Jo, M-Y Kim, H Nojima and Y-H Ahn

   Nutr Diabetes, 5, e179, 2015.
5. Phosphorylation of CHO1 by Lats1/2 regulates the centrosomal activation of LIMK1 during cytokinesis.

   Ayumi Okamoto, Norikazu Yabuta, Satomi Mukai, Kosuke Torigata and Hiroshi Nojima

   Cell Cycle, 14 (10), 1568-1582, 2015.
6. ELAS1-mediated inhibition of the cyclin G1-B'γ interaction promotes cancer cell apoptosis via stabilization and activation of p53.

   S Ohno, Y Naito, S Mukai, N Yabuta and H Nojima

   Oncogene, 34 (49), 5983-5996, 2015.
7. Homeostatic control of Hippo signaling activity revealed by an endogenous activating mutation in YAP.

   Qian Chen, Nailing Zhang, Rui Xie, Wei Wang, Jing Cai, Kyung-Suk Choi, Karen Kate David, Bo Huang, Norikazu Yabuta, Hiroshi Nojima, Robert A Anders and Duojia Pan

   Genes Dev, 29 (12), 1285-1297, 2015.
8. Evasion of affinity-based selection in germinal centers by Epstein-Barr virus LMP2A.

   Takeharu Minamitani, Teruhito Yasui, Yijie Ma, Hufeng Zhou, Daisuke Okuzaki, Chiau-Yuang Tsai, Shuhei Sakakibara, Benjamin E Gewurz, Elliott Kieff and Hitoshi Kikutani

   Proc Natl Acad Sci U S A, 112 (37), 11612-11617, 2015.
9. Withaferin A Induces Cell Death Selectively in Androgen-Independent Prostate Cancer Cells but Not in Normal Fibroblast Cells.

   Yukihiro Nishikawa, Daisuke Okuzaki, Kohshiro Fukushima, Satomi Mukai, Shouichi Ohno, Yuki Ozaki, Norikazu Yabuta and Hiroshi Nojima

   PLoS One, 10 (7), e0134137, 2015.
10. Genetic analysis of genes causing hypertension and stroke in spontaneously hypertensive rats: Gene expression profiles in the kidneys.

    Yuko Watanabe, Momoko Yoshida, Kyosuke Yamanishi, Hideyuki Yamamoto, Daisuke Okuzaki, Hiroshi Nojima, Teruo Yasunaga, Haruki Okamura, Hisato Matsunaga and Hiromichi Yamanishi

    Int J Mol Med, 36 (3), 712-724, 2015.
11. Circulating miR-103 and miR-720 as novel serum biomarkers for patients with colorectal cancer.

    Ryoji Nonaka, Yuichiro Miyake, Taishi Hata, Yoshinori Kagawa, Takeshi Kato, Hideki Osawa, Junichi Nishimura, Masakazu Ikenaga, Kohei Murata, Mamoru Uemura, Daisuke Okuzaki, Ichiro Takemasa, Tsunekazu Mizushima, Hirofumi Yamamoto, Yuichiro Doki and Masaki Mori

    Int J Oncol, 47 (3), 1097-1102, 2015.
12. γ-SNAP stimulates disassembly of endosomal SNARE complexes and regulates endocytic trafficking pathways.

    Hiroki Inoue, Yuka Matsuzaki, Ayaka Tanaka, Kaori Hosoi, Kaoru Ichimura, Kohei Arasaki, Yuichi Wakana, Kenichi Asano, Masato Tanaka, Daisuke Okuzaki, Akitsugu Yamamoto, Katsuko Tani and Mitsuo Tagaya

    J Cell Sci, 128 (15), 2781-2794, 2015.
13. Identification of Non-Coding RNAs Associated with Telomeres Using a Combination of enChIP and RNA Sequencing.

    Toshitsugu Fujita, Miyuki Yuno, Daisuke Okuzaki, Rieko Ohki and Hodaka Fujii

    PLoS One, 10 (4), e0123387, 2015.
14. Estrogen-inducible sFRP5 inhibits early B-lymphopoiesis in vivo, but not during pregnancy.

    Takafumi Yokota, Kenji Oritani, Takao Sudo, Tomohiko Ishibashi, Yukiko Doi, Yoko Habuchi, Michiko Ichii, Kentaro Fukushima, Daisuke Okuzaki, Kazuma Tomizuka, Kengo Yamawaki, Makoto Kakitani, Akihiko Shimono, Eiichi Morii, Paul W Kincade and Yuzuru Kanakura

    Eur J Immunol, 45 (5), 1390-1401, 2015.
15. RFPL4A increases the G1 population and decreases sensitivity to chemotherapy in human colorectal cancer cells.

    Atsushi Naito, Hirofumi Yamamoto, Yoshinori Kagawa, Yoko Naito, Daisuke Okuzaki, Keisuke Otani, Yoriko Iwamoto, Sakae Maeda, Junichi Kikuta, Keizo Nishikawa, Mamoru Uemura, Junichi Nishimura, Taishi Hata, Ichiro Takemasa, Tsunekazu Mizushima, Hideshi Ishii, Yuichiro Doki, Masaki Mori and Masaru Ishii

    J Biol Chem, 290 (10), 6326-6337, 2015.
16. Partial maintenance and long-term expansion of murine skin epithelial stem cells by wnt-3a in vitro.

    Yukiteru Ouji, Shigeaki Ishizaka, Fukumi Nakamura-Uchiyama, Daisuke Okuzaki and Masahide Yoshikawa

    J Invest Dermatol, 135 (6), 1598-1608, 2015.

Link

Department of Molecular Genetics

DNA-chip Development Center for Infectious Diseases

Research Institute for Microbial Diseases, Osaka University