Department of Infection Metagenomics

Staff:

Professor (SUP)

Toshihiro Horii, Ph.D.

Teruo Yasunaga, Ph.D.

Tetsuya Iida, Ph.D.

Assistant Professor (SUP)

Naohisa Goto, Ph. D.

Shota Nakamura, Ph. D.

Specially Appointed Researcher

Daisuke Motooka, Ph. D.

Mizue Anda, Ph. D.

JSPS Postdoctoral Fellowship for Foreign Researcher

Salvatore Cosentino Ph.D.

Subjects:

1. Development of metagenomic diagnosis system for pathogen identification
2. Studies on gut microbiota
3. Application of next-generation sequencing

Papers published in 2015

1. Plasmodium berghei ANKA causes intestinal malaria associated with dysbiosis.

   Tomoyo Taniguchi, Eiji Miyauchi, Shota Nakamura, Makoto Hirai, Kazutomo Suzue, Takashi Imai, Takahiro Nomura, Tadashi Handa, Hiroko Okada, Chikako Shimokawa, Risa Onishi, Alex Olia, Jun Hirata, Haruyoshi Tomita, Hiroshi Ohno, Toshihiro Horii and Hajime Hisaeda

   Sci Rep, 5, 15699, 2015.
2. Structural Basis for Dimer Formation of Human Condensin Structural Maintenance of Chromosome Proteins and Its Implications for Single-stranded DNA Recognition.

   Susumu Uchiyama, Kazuki Kawahara, Yuki Hosokawa, Shunsuke Fukakusa, Hiroya Oki, Shota Nakamura, Yukiko Kojima, Masanori Noda, Rie Takino, Yuya Miyahara, Takahiro Maruno, Yuji Kobayashi, Tadayasu Ohkubo and Kiichi Fukui

   J Biol Chem, 290 (49), 29461-29477, 2015.
3. Next-generation sequencing (NGS) in the identification of encephalitis-causing viruses: Unexpected detection of human herpesvirus 1 while searching for RNA pathogens.

   Karol Perlejewski, Marta Popiel, Tomasz Laskus, Shota Nakamura, Daisuke Motooka, Tomasz Stokowy, Dariusz Lipowski, Agnieszka Pollak, Urszula Lechowicz, Kamila Caraballo Cortés, Adam Stępień, Marek Radkowski and Iwona Bukowska-Ośko

   J Virol Methods, 226, 1-6, 2015.
4. Genomic confirmation of nutrient-dependent mutability of mutators in Escherichia coli.

   Saburo Tsuru, Yuuka Ishizawa, Atsushi Shibai, Yusuke Takahashi, Daisuke Motooka, Shota Nakamura and Tetsuya Yomo

   Genes Cells, 20 (12), 972-981, 2015.
5. Genome-Wide Screening of Genes Required for Glycosylphosphatidylinositol Biosynthesis.

   Yao Rong, Shota Nakamura, Tetsuya Hirata, Daisuke Motooka, Yi-Shi Liu, Zeng-An He, Xiao-Dong Gao, Yusuke Maeda, Taroh Kinoshita and Morihisa Fujita

   PLoS One, 10 (9), e0138553, 2015.
6. Functional specialization in regulation and quality control in thermal adaptive evolution.

   Kazuma Yama, Yuki Matsumoto, Yoshie Murakami, Shigeto Seno, Hideo Matsuda, Kazuyoshi Gotoh, Daisuke Motooka, Shota Nakamura, Bei-Wen Ying and Tetsuya Yomo

   Genes Cells, 20 (11), 943-955, 2015.
7. Periodic Pattern of Genetic and Fitness Diversity during Evolution of an Artificial Cell-Like System.

   Norikazu Ichihashi, Takuyo Aita, Daisuke Motooka, Shota Nakamura and Tetsuya Yomo

   Mol Biol Evol, 32 (12), 3205-3214, 2015.
8. Post-Golgi anterograde transport requires GARP-dependent endosome-to-TGN retrograde transport.

   Tetsuya Hirata, Morihisa Fujita, Shota Nakamura, Kazuyoshi Gotoh, Daisuke Motooka, Yoshiko Murakami, Yusuke Maeda and Taroh Kinoshita

   Mol Biol Cell, 26 (17), 3071-3084, 2015.
9. Baseline Assessment of Mesophotic Reefs of the Vitória-Trindade Seamount Chain Based on Water Quality, Microbial Diversity, Benthic Cover and Fish Biomass Data.

   Pedro M Meirelles, Gilberto M Amado-Filho, Guilherme H Pereira-Filho, Hudson T Pinheiro, Rodrigo L de Moura, Jean-Christophe Joyeux, Eric F Mazzei, Alex C Bastos, Robert A Edwards, Elizabeth Dinsdale, Rodolfo Paranhos, Eidy O Santos, Tetsuya Iida, Kazuyoshi Gotoh, Shota Nakamura, Tomoo Sawabe, Carlos E Rezende, Luiz M R Gadelha, Ronaldo B Francini-Filho, Cristiane Thompson and Fabiano L Thompson

   PLoS One, 10 (6), e0130084, 2015.
10. Cloning, expression, purification, crystallization and X-ray crystallographic analysis of CofB, the minor pilin subunit of CFA/III from human enterotoxigenic Escherichia coli.

    Kazuki Kawahara, Hiroya Oki, Shunsuke Fukakusa, Takahiro Maruno, Yuji Kobayashi, Daisuke Motooka, Tooru Taniguchi, Takeshi Honda, Tetsuya Iida, Shota Nakamura and Tadayasu Ohkubo

    Acta Crystallogr F Struct Biol Commun, 71 (Pt 6), 663-667, 2015.
11. A repeat unit of Vibrio diarrheal T3S effector subverts cytoskeletal actin homeostasis via binding to interstrand region of actin filaments.

    Mitsuhiro Nishimura, Takashi Fujii, Hirotaka Hiyoshi, Fumiaki Makino, Hajime Inoue, Daisuke Motooka, Toshio Kodama, Tadayasu Ohkubo, Yuji Kobayashi, Shota Nakamura, Keiichi Namba and Tetsuya Iida

    Sci Rep, 5, 10870, 2015.
12. Emergence of infectious malignant thrombocytopenia in Japanese macaques (Macaca fuscata) by SRV-4 after transmission to a novel host.

    Munehiro Okamoto, Takayuki Miyazawa, Shigeru Morikawa, Fumiko Ono, Shota Nakamura, Eiji Sato, Tomoyuki Yoshida, Rokusuke Yoshikawa, Kouji Sakai, Tetsuya Mizutani, Noriyo Nagata, Jun-Ichiro Takano, Sachi Okabayashi, Masataka Hamano, Koji Fujimoto, Takaaki Nakaya, Tetsuya Iida, Toshihiro Horii, Takako Miyabe-Nishiwaki, Akino Watanabe, Akihisa Kaneko, Akatsuki Saito, Atsushi Matsui, Toshiyuki Hayakawa, Juri Suzuki, Hirofumi Akari, Tetsuro Matsuzawa and Hirohisa Hirai

    Sci Rep, 5, 8850, 2015.
13. Structural basis for PPARγ transactivation by endocrine-disrupting organotin compounds.

    Shusaku Harada, Youhei Hiromori, Shota Nakamura, Kazuki Kawahara, Shunsuke Fukakusa, Takahiro Maruno, Masanori Noda, Susumu Uchiyama, Kiichi Fukui, Jun-ichi Nishikawa, Hisamitsu Nagase, Yuji Kobayashi, Takuya Yoshida, Tadayasu Ohkubo and Tsuyoshi Nakanishi

    Sci Rep, 5, 8520, 2015.
14. Viral detection by high-throughput sequencing.

    Daisuke Motooka, Shota Nakamura, Katsuro Hagiwara and Takaaki Nakaya

    Methods Mol Biol, 1236, 125-134, 2015.
15. Homo-trimeric Structure of the Type IVb Minor Pilin CofB Suggests Mechanism of CFA/III Pilus Assembly in Human Enterotoxigenic Escherichia coli.

    Kazuki Kawahara, Hiroya Oki, Shunsuke Fukakusa, Takuya Yoshida, Tomoya Imai, Takahiro Maruno, Yuji Kobayashi, Daisuke Motooka, Tetsuya Iida, Tadayasu Ohkubo and Shota Nakamura

    J Mol Biol, 61 (6), 1209-1226, 2016.

Link

Department of Infection Metagenomics

Research Institute for Microbial Diseases, Osaka University