Department of Signal Transduction

Staff:

Professor

Nobuyuki Takakura, M.D., Ph.D.

Assistant Professor

Hiroyasu Kidoya, Ph.D.

Hisamichi Naito, M.D., Ph.D.

Specially Appointed Researcher

Yinglu Han, Ph.D.

Daishi Yamakawa, Ph.D.

Weizhen Jia, Ph.D.

Taku Wakabayashi, M.D., Ph.D.

Chie Takeshita

Graduate Student

Kazuhiro Takara

Hiroki Kawahara

Gong Zhiyuan

Zhang Li

Ryu Kanzaki

Fumitaka Muramatsu

Keitaro Yamane

Tomoko Kosaka

Hironori Yoshida

Daisuku Eino

Miku Kitta

Yumiko Hayashi

Shoko Hosojima

Research Student

Nobuaki Ooto

Subjects:

1. Elucidation of the tube-forming mechanism by investigating the polarity of ECs.
2. Analysis of the functional role(s) of Tie2 and down stream of Tie2 in the maturation of blood vessels.
3. Analysis of hematopoietic cells in angiogenesis.
4. Analysis of specification between artery and vein.
5. Analysis of stem cell system in blood vessels.
6. Functional analysis of GINS complex and galectin-3 in stem cells.

Papers published in 2014

1. DNA Damage Enhanced by the Attenuation of SLD5 Delays Cell Cycle Restoration in Normal Cells but Not in Cancer Cells.

   Zhi-Yuan Gong, Hiroyasu Kidoya, Tomomi Mohri, Yinglu Han and Nobuyuki Takakura

   PLoS One, 9 (10), e110483, 2014.
2. Myocardium-derived angiopoietin-1 is essential for coronary vein formation in the developing heart.

   Yoh Arita, Yoshikazu Nakaoka, Taichi Matsunaga, Hiroyasu Kidoya, Kohei Yamamizu, Yuichiro Arima, Takahiro Kataoka-Hashimoto, Kuniyasu Ikeoka, Taku Yasui, Takeshi Masaki, Kaori Yamamoto, Kaori Higuchi, Jin-Sung Park, Manabu Shirai, Koichi Nishiyama, Hiroyuki Yamagishi, Kinya Otsu, Hiroki Kurihara, Takashi Minami, Keiko Yamauchi-Takihara, Gou Y Koh, Naoki Mochizuki, Nobuyuki Takakura, Yasushi Sakata, Jun K Yamashita and Issei Komuro

   Nat Commun, 5, 4552, 2014.
3. Selenoprotein P as a diabetes-associated hepatokine that impairs angiogenesis by inducing VEGF resistance in vascular endothelial cells.

   Kazuhide Ishikura, Hirofumi Misu, Masafumi Kumazaki, Hiroaki Takayama, Naoto Matsuzawa-Nagata, Natsumi Tajima, Keita Chikamoto, Fei Lan, Hitoshi Ando, Tsuguhito Ota, Masaru Sakurai, Yumie Takeshita, Kenichiro Kato, Akio Fujimura, Ken-Ichi Miyamoto, Yoshiro Saito, Satomi Kameo, Yasuo Okamoto, Yoh Takuwa, Kazuhiko Takahashi, Hiroyasu Kidoya, Nobuyuki Takakura, Shuichi Kaneko and Toshinari Takamura

   Diabetologia, 57 (9), 1968-1976, 2014.
4. Contribution of calumin to embryogenesis through participation in the endoplasmic reticulum-associated degradation activity.

   Shinichiro Yamamoto, Tetsuo Yamazaki, Shinji Komazaki, Takeshi Yamashita, Masako Osaki, Masaya Matsubayashi, Hiroyasu Kidoya, Nobuyuki Takakura, Daiju Yamazaki and Sho Kakizawa

   Dev Biol, 393 (1), 33-43, 2014.
5. CD44 expressed on cancer-associated fibroblasts is a functional molecule supporting the stemness and drug resistance of malignant cancer cells in the tumor microenvironment.

   Yumi Kinugasa, Takahiro Matsui and Nobuyuki Takakura

   Stem Cells, 32 (1), 145-156, 2014.

Link

Department of Signal Transduction

Research Institute for Microbial Diseases, Osaka University