Department of Molecular Virology

Staff:

Professor

Yoshiharu Matsuura, D.V.M., Ph.D.

Assistant Professor

Toru Okamoto, Ph.D.

Takasuke Fukuhara, M.D., Ph.D.

JSPS Postdoctoral Fellowship

Hiroshi Katoh, Ph.D.

Specially Appointed Researcher

Chikako Ono, Ph.D.

Takashi Motomura, M.D.

Sayaka Aizawa, Ph.D.

Masami Wada, Ph.D.

Puig-Basagoiti Francesc, Ph.D.

Graduate Student

Akinori Ninomiya

Mai Shiokawa

Pham Ngoc Duc

Takahisa Kouwaki

Satomi Yamamoto

Takahiro Kawagishi

Eiji Hirooka

Research Student

Ryoichi Shima

Tatsuya Miyoshi

Yoshihiko Morishita

Subjects:

1. Studies on hepatitis C virus.
2. Studies on Japanese encephalitis virus.
3. Studies on hepatitis B virus.
4. Development of viral vectors.

Papers published in 2014

1. Alternative endocytosis pathway for productive entry of hepatitis C virus.

   Mami Matsuda, Ryosuke Suzuki, Chikako Kataoka, Koichi Watashi, Hideki Aizaki, Nobuyuki Kato, Yoshiharu Matsuura, Tetsuro Suzuki and Takaji Wakita

   J Gen Virol, 95 (Pt 12), 2658-2667, 2014.
2. Hallmarks of hepatitis C virus in equine hepacivirus.

   Tomohisa Tanaka, Hirotake Kasai, Atsuya Yamashita, Kaori Okuyama-Dobashi, Jun Yasumoto, Shinya Maekawa, Nobuyuki Enomoto, Toru Okamoto, Yoshiharu Matsuura, Masami Morimatsu, Noboru Manabe, Kazuhiko Ochiai, Kazuto Yamashita and Kohji Moriishi

   J Virol, 88 (22), 13352-13366, 2014.
3. Amphipathic α-helices in apolipoproteins are crucial to the formation of infectious hepatitis C virus particles.

   Takasuke Fukuhara, Masami Wada, Shota Nakamura, Chikako Ono, Mai Shiokawa, Satomi Yamamoto, Takashi Motomura, Toru Okamoto, Daisuke Okuzaki, Masahiro Yamamoto, Izumu Saito, Takaji Wakita, Kazuhiko Koike and Yoshiharu Matsuura

   PLoS Pathog, 10 (12), e1004534, 2014.
4. Interferon-lambda4 genetic polymorphism is associated with the therapy response for hepatitis C virus recurrence after a living donor liver transplant.

   H Konishi, T Motomura, Y Matsumoto, N Harimoto, T Ikegami, T Yoshizumi, Y Soejima, K Shirabe, T Fukuhara and Y Maehara

   J Viral Hepat, 21 (6), 397-404, 2014.
5. Reduced-dose telaprevir-based triple antiviral therapy for recurrent hepatitis C after living donor liver transplantation.

   Toru Ikegami, Tomoharu Yoshizumi, Masaki Kato, Satomi Yamamoto, Takasuke Fukuhara, Yoshiharu Matsuura, Shota Nakamura, Shinji Itoh, Ken Shirabe and Yoshihiko Maehara

   Transplantation, 98 (9), 994-999, 2014.
6. Suppression of autophagy during liver regeneration impairs energy charge and hepatocyte senescence in mice.

   Takeo Toshima, Ken Shirabe, Takasuke Fukuhara, Toru Ikegami, Tomoharu Yoshizumi, Yuji Soejima, Tetsuo Ikeda, Shinji Okano and Yoshihiko Maehara

   Hepatology, 60 (1), 290-300, 2014.
7. Novel permissive cell lines for complete propagation of hepatitis C virus.

   Mai Shiokawa, Takasuke Fukuhara, Chikako Ono, Satomi Yamamoto, Toru Okamoto, Noriyuki Watanabe, Takaji Wakita and Yoshiharu Matsuura

   J Virol, 88 (10), 5578-5594, 2014.
8. Binding of HSV-1 glycoprotein K (gK) to signal peptide peptidase (SPP) is required for virus infectivity.

   Sariah J Allen, Kevin R Mott, Yoshiharu Matsuura, Kohji Moriishi, Konstantin G Kousoulas and Homayon Ghiasi

   PLoS One, 9 (1), e85360, 2014.
9. Detection of hepatitis C virus by single-step hairpin primer RT-PCR.

   Fumie Takei, Hideki Tani, Yoshiharu Matsuura and Kazuhiko Nakatani

   Bioorg Med Chem Lett, 24 (1), 394-396, 2014.
10. Enhanced stability of Mcl1, a prosurvival Bcl2 relative, blunts stress-induced apoptosis, causes male sterility, and promotes tumorigenesis.

    Toru Okamoto, Leigh Coultas, Donald Metcalf, Mark F van Delft, Stefan P Glaser, Megumi Takiguchi, Andreas Strasser, Philippe Bouillet, Jerry M Adams and David C S Huang

    Proc Natl Acad Sci U S A, 111 (1), 261-266, 2014.
11. Targeting of MCL-1 kills MYC-driven mouse and human lymphomas even when they bear mutations in p53.

    Gemma L Kelly, Stephanie Grabow, Stefan P Glaser, Leah Fitzsimmons, Brandon J Aubrey, Toru Okamoto, Liz J Valente, Mikara Robati, Lin Tai, W Douglas Fairlie, Erinna F Lee, Mikael S Lindstrom, Klas G Wiman, David C S Huang, Philippe Bouillet, Martin Rowe, Alan B Rickinson, Marco J Herold and Andreas Strasser

    Genes Dev, 28 (1), 58-70, 2014.
12. Innate immune response induced by baculovirus attenuates transgene expression in Mammalian cells.

    Chikako Ono, Akinori Ninomiya, Satomi Yamamoto, Takayuki Abe, Xiauyu Wen, Takasuke Fukuhara, Miwa Sasai, Masahiro Yamamoto, Tatsuya Saitoh, Takashi Satoh, Taro Kawai, Ken J Ishii, Shizuo Akira, Toru Okamoto and Yoshiharu Matsuura

    J Virol, 88 (4), 2157-2167, 2014.

Link

Department of Molecular Virology

Research Institute for Microbial Diseases, Osaka University