Department of Molecular Protozoology

Subjects:

Professor

Toshihiro Horii, Ph.D.

Specially Appointed Professor

Eisaku Kimura, M.D., Ph.D.

Specially Appointed Associate Professor

Palacpac, Nirianne Marie Querijero, Ph.D.

Assistant Professor

Takahiro Tougan, Ph.D.

Nobuko Arisue, Ph.D.

Specially Appointed Researcher

Masanori Yagi, Ph.D.

Jyotheeswara Reddy Edula, Ph.D.

Subjects:

1. Development of malaria vaccine based on Plasmodium falciparum SERA5.
2. Study on the function of SERA5 protein.
3. Study on host-parasite interaction of malaria infection.
4. Study on host switch history and its molecular mechanism of Plasmodium species.

Papers published in 2014

1. Protective epitopes of the Plasmodium falciparum SERA5 malaria vaccine reside in intrinsically unstructured N-terminal repetitive sequences.

   Masanori Yagi, Gilles Bang, Takahiro Tougan, Nirianne M Q Palacpac, Nobuko Arisue, Taiki Aoshi, Yoshitsugu Matsumoto, Ken J Ishii, Thomas G Egwang, Pierre Druilhe and Toshihiro Horii

   PLoS One, 9 (6), e98460, 2014.
2. Hematological and biochemical data obtained in rural northern Uganda.

   Nirianne M Q Palacpac, Edward Ntege, Betty Balikagala, Adoke Yeka, Hiroki Shirai, Nahoko Suzuki, Christopher Nsereko, Bernard N Kanoi, Takuya Okada, Thomas G Egwang and Toshihiro Horii

   Int J Environ Res Public Health, 11 (5), 4870-4885, 2014.
3. Characteristic age distribution of Plasmodium vivax infections after malaria elimination on Aneityum Island, Vanuatu.

   Akira Kaneko, Luis F Chaves, George Taleo, Morris Kalkoa, Rie Isozumi, Renu Wickremasinghe, Hedvig Perlmann, Satoru Takeo, Takafumi Tsuboi, Shin-ichiro Tachibana, Masatsugu Kimura, Anders Björkman, Marita Troye-Blomberg, Kazuyuki Tanabe and Chris Drakeley

   Infect Immun, 82 (1), 243-252, 2014.
4. Ordered accumulation of mutations conferring resistance to sulfadoxine-pyrimethamine in the Plasmodium falciparum parasite.

   Toshihiro Mita, Jun Ohashi, Meera Venkatesan, Aung Swi Prue Marma, Masatoshi Nakamura, Christopher V Plowe and Kazuyuki Tanabe

   J Infect Dis, 209 (1), 130-139, 2014.
5. Comprehensive metagenomic approach for detecting causative microorganisms in culture-negative infective endocarditis.

   Atsuko Imai, Kazuyoshi Gotoh, Yoshihiro Asano, Noriaki Yamada, Daisuke Motooka, Masaki Fukushima, Machiko Kanzaki, Tomohito Ohtani, Yasushi Sakata, Hiroyuki Nishi, Koichi Toda, Yoshiki Sawa, Issei Komuro, Toshihiro Horii, Tetsuya Iida, Shota Nakamura and Seiji Takashima

   Int J Cardiol, 172 (2), e288-289, 2014.
6. Generation of Rodent Malaria Parasites with a High Mutation Rate by Destructing Proofreading Activity of DNA Polymerase δ.

   Hajime Honma, Makoto Hirai, Shota Nakamura, Hassan Hakimi, Shin-Ichiro Kawazu, Nirianne M Q Palacpac, Hajime Hisaeda, Hiroyuki Matsuoka, Satoru Kawai, Hiroyoshi Endo, Teruo Yasunaga, Jun Ohashi, Toshihiro Mita, Toshihiro Horii, Mitsuru Furusawa and Kazuyuki Tanabe

   DNA Res, 21 (4), 439-446, 2014.
7. Olfactory plays a key role in spatiotemporal pathogenesis of cerebral malaria.

   Hong Zhao, Taiki Aoshi, Satoru Kawai, Yuki Mori, Aki Konishi, Muge Ozkan, Yukiko Fujita, Yasunari Haseda, Mikiko Shimizu, Masako Kohyama, Kouji Kobiyama, Kei Eto, Junichi Nabekura, Toshihiro Horii, Tomoko Ishino, Masao Yuda, Hiroaki Hemmi, Tsuneyasu Kaisho, Shizuo Akira, Manabu Kinoshita, Koujiro Tohyama, Yoshichika Yoshioka, Ken J Ishii and Cevayir Coban

   Cell Host Microbe, 15 (5), 551-563, 2014.

Link

Department of Molecular Protozoology

Research Institute for Microbial Diseases, Osaka University