Department of Molecular Genetics

Staff:

Professor

Hiroshi Nojima, Ph.D.

Associate Professor

Norikazu Yabuta, Ph.D.

Assistant Professor (SUP)

Daisuke Okuzaki, Ph.D.

Specially Appointed Researcher

Satomi Mukai, Ph.D.

Researcher

Yuki Sekine

Research Collaborator

Daisaku Miura, Ph.D.

Graduate Student

Hirokazu Suzuki

Ayumi Okamoto

Shouichi Ohno

Kosuke Torigata

Yumi Ando

Towa Sasakura

Katsuma Matsuura

Kohshiro Fukushima

Wang Mian

Subjects:

1. Molecular mechanisms regulating the cell cycle (checkpoint) in mammalian cells.
2. Molecular mechanisms modulating the malignancy of cancer cells.
3. Application of a new technique (Leuko Catch) to RNA diagnosis.

Papers published in 2014

1. Amphipathic α-helices in apolipoproteins are crucial to the formation of infectious hepatitis C virus particles.

   Takasuke Fukuhara, Masami Wada, Shota Nakamura, Chikako Ono, Mai Shiokawa, Satomi Yamamoto, Takashi Motomura, Toru Okamoto, Daisuke Okuzaki, Masahiro Yamamoto, Izumu Saito, Takaji Wakita, Kazuhiko Koike and Yoshiharu Matsuura

   PLoS Pathog, 10 (12), e1004534, 2014.
2. Identification of Creb3l4 as an essential negative regulator of adipogenesis.

   T-H Kim, S-H Jo, H Choi, J-M Park, M-Y Kim, H Nojima, J-W Kim and Y-H Ahn

   Cell Death Dis, 5, e1527, 2014.
3. Circulating miR-199a-3p as a novel serum biomarker for colorectal cancer.

   Ryoji Nonaka, Junichi Nishimura, Yoshinori Kagawa, Hideki Osawa, Junichi Hasegawa, Kohei Murata, Shu Okamura, Hirofumi Ota, Mamoru Uemura, Taishi Hata, Ichiro Takemasa, Tsunekazu Mizushima, Daisuke Okuzaki, Hirofumi Yamamoto, Yuichiro Doki and Masaki Mori

   Oncol Rep, 32 (6), 2354-2358, 2014.
4. MicroRNA-1246 expression associated with CCNG2-mediated chemoresistance and stemness in pancreatic cancer.

   S Hasegawa, H Eguchi, H Nagano, M Konno, Y Tomimaru, H Wada, N Hama, K Kawamoto, S Kobayashi, N Nishida, J Koseki, T Nishimura, N Gotoh, S Ohno, N Yabuta, H Nojima, M Mori, Y Doki and H Ishii

   Br J Cancer, 111 (8), 1572-1580, 2014.
5. Gefitinib and Luteolin Cause Growth Arrest of Human Prostate Cancer PC-3 Cells via Inhibition of Cyclin G-Associated Kinase and Induction of miR-630.

   Minami A Sakurai, Yuki Ozaki, Daisuke Okuzaki, Yoko Naito, Towa Sasakura, Ayumi Okamoto, Hiroe Tabara, Takao Inoue, Man Hagiyama, Akihiko Ito, Norikazu Yabuta and Hiroshi Nojima

   PLoS One, 9 (6), e100124, 2014.
6. Signal-transducing adaptor protein-2 regulates macrophage migration into inflammatory sites during dextran sodium sulfate induced colitis.

   Natsuko Fujita, Kenji Oritani, Michiko Ichii, Takafumi Yokota, Norimitsu Saitoh, Daisuke Okuzaki, Yuichi Sekine, Shigeyuki Kon, Ryuta Muromoto, Kodai Saitoh, Akihiko Yoshimura, Tadashi Matsuda and Yuzuru Kanakura

   Eur J Immunol, 44 (6), 1791-1801, 2014.
7. A functional interaction between Hippo-YAP signalling and FoxO1 mediates the oxidative stress response.

   Dan Shao, Peiyong Zhai, Dominic P Del Re, Sebastiano Sciarretta, Norikazu Yabuta, Hiroshi Nojima, Dae-Sik Lim, Duojia Pan and Junichi Sadoshima

   Nat Commun, 5, 3315, 2014.
8. Analysis of genes causing hypertension and stroke in spontaneously hypertensive rats: Gene expression profiles in the brain.

   Momoko Yoshida, Yuko Watanabe, Kyosuke Yamanishi, Akifumi Yamashita, Hideyuki Yamamoto, Daisuke Okuzaki, Kazunori Shimada, Hiroshi Nojima, Teruo Yasunaga, Haruki Okamura, Hisato Matsunaga and Hiromichi Yamanishi

   Int J Mol Med, 33 (4), 887-896, 2014.

Link

Department of Molecular Genetics

DNA-chip Development Center for Infectious Diseases

Research Institute for Microbial Diseases, Osaka University