Department of Immunochemistry

Staff:

Professor (SUP)

Hisashi Arase, M.D., Ph.D.

Associate Professor (SUP)

Tadahiro Suenaga, M.D., Ph.D.

Masako Kohyama, Ph.D.

Specially Appointed Researcher

Fumiji Saito, Ph.D.

Graduate Student

Kazuki Kishida

Yoshiko Sugimoto

Subjects:

1. Molecular mechanisms of autoimmune disease.
2. Role of paired receptors in host-pathogen interaction.
3. Mechanism of virus entry into cells.

Papers published in 2014

1. Engineering large viral DNA genomes using the CRISPR-Cas9 system.

   Tadahiro Suenaga, Masako Kohyama, Kouyuki Hirayasu and Hisashi Arase

   Microbiol Immunol, 58 (9), 513-522, 2014.
2. A motif in LILRB2 critical for Angptl2 binding and activation.

   Mi Deng, Zhigang Lu, Junke Zheng, Xuan Wan, Xiaoli Chen, Kouyuki Hirayasu, Hanzi Sun, Yeeling Lam, Liping Chen, Qihui Wang, Chun Song, Niu Huang, George F Gao, Youxing Jiang, Hisashi Arase and Cheng Cheng Zhang

   Blood, 124 (6), 924-935, 2014.
3. Structural basis for simultaneous recognition of an O-glycan and its attached peptide of mucin family by immune receptor PILRα.

   Kimiko Kuroki, Jing Wang, Toyoyuki Ose, Munechika Yamaguchi, Shigekazu Tabata, Nobuo Maita, Seiko Nakamura, Mizuho Kajikawa, Amane Kogure, Takeshi Satoh, Hisashi Arase and Katsumi Maenaka

   Proc Natl Acad Sci U S A, 111 (24), 8877-8882, 2014.
4. Regulation of immune responses by neutrophils.

   Jing Wang and Hisashi Arase

   Ann N Y Acad Sci, 1319 (1), 66-81, 2014.
5. Olfactory plays a key role in spatiotemporal pathogenesis of cerebral malaria.

   Hong Zhao, Taiki Aoshi, Satoru Kawai, Yuki Mori, Aki Konishi, Muge Ozkan, Yukiko Fujita, Yasunari Haseda, Mikiko Shimizu, Masako Kohyama, Kouji Kobiyama, Kei Eto, Junichi Nabekura, Toshihiro Horii, Tomoko Ishino, Masao Yuda, Hiroaki Hemmi, Tsuneyasu Kaisho, Shizuo Akira, Manabu Kinoshita, Koujiro Tohyama, Yoshichika Yoshioka, Ken J Ishii and Cevayir Coban

   Cell Host Microbe, 15 (5), 551-563, 2014.
6. Heme-mediated SPI-C induction promotes monocyte differentiation into iron-recycling macrophages.

   Malay Haldar, Masako Kohyama, Alex Yick-Lun So, Wumesh Kc, Xiaodi Wu, Carlos G Briseño, Ansuman T Satpathy, Nicole M Kretzer, Hisashi Arase, Namakkal S Rajasekaran, Li Wang, Takeshi Egawa, Kazuhiko Igarashi, David Baltimore, Theresa L Murphy and Kenneth M Murphy

   Cell, 156 (6), 1223-1234, 2014.
7. Autoantibodies to IgG/HLA class II complexes are associated with rheumatoid arthritis susceptibility.

   Hui Jin, Noriko Arase, Kouyuki Hirayasu, Masako Kohyama, Tadahiro Suenaga, Fumiji Saito, Kenji Tanimura, Sumiko Matsuoka, Kosuke Ebina, Kenrin Shi, Noriko Toyama-Sorimachi, Shinsuke Yasuda, Tetsuya Horita, Ryosuke Hiwa, Kiyoshi Takasugi, Koichiro Ohmura, Hideki Yoshikawa, Takashi Saito, Tatsuya Atsumi, Takehiko Sasazuki, Ichiro Katayama, Lewis L Lanier and Hisashi Arase

   Proc Natl Acad Sci U S A, 111 (10), 3787-3792, 2014.

Link

Department of Immunochemistry

Research Institute for Microbial Diseases, Osaka University