Department of Host Defense

Staff:

Professor(SUP)

Shizuo Akira, M.D., Ph.D.

Associate Professor

Tatsuya Saitoh, Ph.D.

Assistant Professor

Takashi Satoh, Ph.D.

Specially Appointed Assistant Researcher(SUP)

Kenta Maruyama, M.D., Ph.D.

Specially Appointed Assistant Researcher

Mikael Martino, Ph.D.

Specially Appointed Researcher

Hiroki Tanaka, Ph.D.

Kanako Kuniyoshi, Ph.D.

JSPS Postdoctoral Fellowship

Takuma Misawa, Ph.D.

Graduate Student

Tatsuya Kozaki

Yuichi Kitai

Sarang Tartey

Guoliang Mao

Liang Zhao

Fumihiro Yamane

Hisashi Kanemaru

Kiyoharu Fukushima

Reiko Mishima

Sehoon Park

Xin Sun

Under Graduate Student

Kojin Miura

Noriyuki Miyamoto

Ryo Takenaka

Subjects:

1. Analysis of innate immune response mediated by pattern-recognition receptor family
2. Analysis of M2 and M2-like macrophages
3. Development of therapeutic treatments for immune-related disorders

Papers published in 2014

1. An epigenetic switch induced by Shh signalling regulates gene activation during development and medulloblastoma growth.

   Xuanming Shi, Zilai Zhang, Xiaoming Zhan, Mou Cao, Takashi Satoh, Shizuo Akira, Karl Shpargel, Terry Magnuson, Qingtian Li, Rongfu Wang, Chaochen Wang, Kai Ge and Jiang Wu

   Nat Commun, 5, 5425, 2014.
2. B Cell-Intrinsic TLR7 Signaling Is Essential for the Development of Spontaneous Germinal Centers.

   Chetna Soni, Eric B Wong, Phillip P Domeier, Tahsin N Khan, Takashi Satoh, Shizuo Akira and Ziaur S M Rahman

   J Immunol, 193 (9), 4400-4414, 2014.
3. JAK2V617F+ myeloproliferative neoplasm clones evoke paracrine DNA damage to adjacent normal cells through secretion of lipocalin-2.

   Yuki Kagoya, Akihide Yoshimi, Takako Tsuruta-Kishino, Shunya Arai, Takashi Satoh, Shizuo Akira and Mineo Kurokawa

   Blood, 124 (19), 2996-3006, 2014.
4. Cytosolic double-stranded RNA activates the NLRP3 inflammasome via MAVS-induced membrane permeabilization and K+ efflux.

   Luigi Franchi, Tatjana Eigenbrod, Raúl Muñoz-Planillo, Ulas Ozkurede, Yun-Gi Kim, Arindam Chakrabarti, Michael Gale, Robert H Silverman, Marco Colonna, Shizuo Akira and Gabriel Núñez

   J Immunol, 193 (8), 4214-4222, 2014.
5. Innate lymphoid cells regulate intestinal epithelial cell glycosylation.

   Yoshiyuki Goto, Takashi Obata, Jun Kunisawa, Shintaro Sato, Ivaylo I Ivanov, Aayam Lamichhane, Natsumi Takeyama, Mariko Kamioka, Mitsuo Sakamoto, Takahiro Matsuki, Hiromi Setoyama, Akemi Imaoka, Satoshi Uematsu, Shizuo Akira, Steven E Domino, Paulina Kulig, Burkhard Becher, Jean-Christophe Renauld, Chihiro Sasakawa, Yoshinori Umesaki, Yoshimi Benno and Hiroshi Kiyono

   Science, 345 (6202), 1254009, 2014.
6. TRIF signaling drives homeostatic intestinal epithelial antimicrobial peptide expression.

   Silvia Stockinger, Claudia U Duerr, Marcus Fulde, Tamas Dolowschiak, Johanna Pott, Ines Yang, Daniel Eibach, Fredrik Bäckhed, Shizuo Akira, Sebastian Suerbaum, Martijn Brugman and Mathias W Hornef

   J Immunol, 193 (8), 4223-4234, 2014.
7. Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia.

   Panagiotis Ntziachristos, Aristotelis Tsirigos, G Grant Welstead, Thomas Trimarchi, Sofia Bakogianni, Luyao Xu, Evangelia Loizou, Linda Holmfeldt, Alexandros Strikoudis, Bryan King, Jasper Mullenders, Jared Becksfort, Jelena Nedjic, Elisabeth Paietta, Martin S Tallman, Jacob M Rowe, Giovanni Tonon, Takashi Satoh, Laurens Kruidenier, Rab Prinjha, Shizuo Akira, Pieter Van Vlierberghe, Adolfo A Ferrando, Rudolf Jaenisch, Charles G Mullighan and Iannis Aifantis

   Nature, 514 (7523), 513-517, 2014.
8. MyD88 signaling inhibits protective immunity to the gastrointestinal helminth parasite Heligmosomoides polygyrus.

   Lisa A Reynolds, Yvonne Harcus, Katherine A Smith, Lauren M Webb, James P Hewitson, Ewan A Ross, Sheila Brown, Satoshi Uematsu, Shizuo Akira, David Gray, Mohini Gray, Andrew S MacDonald, Adam F Cunningham and Rick M Maizels

   J Immunol, 193 (6), 2984-2993, 2014.
9. Akirin2 is critical for inducing inflammatory genes by bridging IκB-ζ and the SWI/SNF complex.

   Sarang Tartey, Kazufumi Matsushita, Alexis Vandenbon, Daisuke Ori, Tomoko Imamura, Takashi Mino, Daron M Standley, Jules A Hoffmann, Jean-Marc Reichhart, Shizuo Akira and Osamu Takeuchi

   EMBO J, 33 (20), 2332-2348, 2014.
10. TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis.

    Sayaka Inokuchi-Shimizu, Eek Joong Park, Yoon Seok Roh, Ling Yang, Bi Zhang, Jingyi Song, Shuang Liang, Michael Pimienta, Koji Taniguchi, Xuefeng Wu, Kinji Asahina, William Lagakos, Mason R Mackey, Shizuo Akira, Mark H Ellisman, Dorothy D Sears, Jerrold M Olefsky, Michael Karin, David A Brenner and Ekihiro Seki

    J Clin Invest, 124 (8), 3566-3578, 2014.
11. The parasitophorous vacuole membrane of Toxoplasma gondii is targeted for disruption by ubiquitin-like conjugation systems of autophagy.

    Jayoung Choi, Sunmin Park, Scott B Biering, Elizabeth Selleck, Catherine Y Liu, Xin Zhang, Naonobu Fujita, Tatsuya Saitoh, Shizuo Akira, Tamotsu Yoshimori, L David Sibley, Seungmin Hwang and Herbert W Virgin

    Immunity, 40 (6), 924-935, 2014.
12. The Early Activation of CD8(+) T Cells Is Dependent on Type I IFN Signaling following Intramuscular Vaccination of Adenovirus Vector.

    Masahisa Hemmi, Masashi Tachibana, Sayaka Tsuzuki, Masaki Shoji, Fuminori Sakurai, Kenji Kawabata, Kouji Kobiyama, Ken J Ishii, Shizuo Akira and Hiroyuki Mizuguchi

    Biomed Res Int, 2014, 158128, 2014.
13. Prospective signs of cleidocranial dysplasia in Cebpb deficiency.

    Boyen Huang, Katsu Takahashi, Ernest A Jennings, Pongthorn Pumtang-On, Honoka Kiso, Yumiko Togo, Kazuyuki Saito, Manabu Sugai, Shizuo Akira, Akira Shimizu and Kazuhisa Bessho

    J Biomed Sci, 21, 44, 2014.
14. Highly pathogenic avian influenza A H5N1 and pandemic H1N1 virus infections have different phenotypes in Toll-like receptor 3 knockout mice.

    Y H Connie Leung, John M Nicholls, Chuk Kwan Ho, Sin Fun Sia, Chris K P Mok, Sophie A Valkenburg, Peter Cheung, Kenrie P Y Hui, Renee W Y Chan, Y Guan, S Akira and J S Malik Peiris

    J Gen Virol, 95 (Pt 9), 1870-1879, 2014.
15. Positive feedback within a kinase signaling complex functions as a switch mechanism for NF-κB activation.

    Hisaaki Shinohara, Marcelo Behar, Kentaro Inoue, Michio Hiroshima, Tomoharu Yasuda, Takeshi Nagashima, Shuhei Kimura, Hideki Sanjo, Shiori Maeda, Noriko Yumoto, Sewon Ki, Shizuo Akira, Yasushi Sako, Alexander Hoffmann, Tomohiro Kurosaki and Mariko Okada-Hatakeyama

    Science, 344 (6185), 760-764, 2014.
16. Olfactory plays a key role in spatiotemporal pathogenesis of cerebral malaria.

    Hong Zhao, Taiki Aoshi, Satoru Kawai, Yuki Mori, Aki Konishi, Muge Ozkan, Yukiko Fujita, Yasunari Haseda, Mikiko Shimizu, Masako Kohyama, Kouji Kobiyama, Kei Eto, Junichi Nabekura, Toshihiro Horii, Tomoko Ishino, Masao Yuda, Hiroaki Hemmi, Tsuneyasu Kaisho, Shizuo Akira, Manabu Kinoshita, Koujiro Tohyama, Yoshichika Yoshioka, Ken J Ishii and Cevayir Coban

    Cell Host Microbe, 15 (5), 551-563, 2014.
17. Epicutaneously applied Der p 2 induces a strong TH 2-biased antibody response in C57BL/6 mice, independent of functional TLR4.

    C Stremnitzer, K Manzano-Szalai, P Starkl, A Willensdorfer, S Schrom, J Singer, U Reichart, S Akira and E Jensen-Jarolim

    Allergy, 69 (6), 741-751, 2014.
18. The enzyme Cyp26b1 mediates inhibition of mast cell activation by fibroblasts to maintain skin-barrier homeostasis.

    Yosuke Kurashima, Takeaki Amiya, Kumiko Fujisawa, Naoko Shibata, Yuji Suzuki, Yuta Kogure, Eri Hashimoto, Atsushi Otsuka, Kenji Kabashima, Shintaro Sato, Takeshi Sato, Masato Kubo, Shizuo Akira, Kensuke Miyake, Jun Kunisawa and Hiroshi Kiyono

    Immunity, 40 (4), 530-541, 2014.
19. Nucleic acid sensing by T cells initiates Th2 cell differentiation.

    Takayuki Imanishi, Chitose Ishihara, Mohamed El Sherif Gadelhaq Badr, Akiko Hashimoto-Tane, Yayoi Kimura, Taro Kawai, Osamu Takeuchi, Ken J Ishii, Shun'ichiro Taniguchi, Tetsuo Noda, Hisashi Hirano, Frank Brombacher, Glen N Barber, Shizuo Akira and Takashi Saito

    Nat Commun, 5, 3566, 2014.
20. Pivotal role of RNA-binding E3 ubiquitin ligase MEX3C in RIG-I-mediated antiviral innate immunity.

    Kanako Kuniyoshi, Osamu Takeuchi, Surya Pandey, Takashi Satoh, Hidenori Iwasaki, Shizuo Akira and Taro Kawai

    Proc Natl Acad Sci U S A, 111 (15), 5646-5651, 2014.
21. RIG-I detects mRNA of intracellular Salmonella enterica serovar Typhimurium during bacterial infection.

    Mirco Schmolke, Jenish R Patel, Elisa de Castro, Maria T Sánchez-Aparicio, Melissa B Uccellini, Jennifer C Miller, Balaji Manicassamy, Takashi Satoh, Taro Kawai, Shizuo Akira, Miriam Merad and Adolfo García-Sastre

    MBio, 5 (2), e01006-01014, 2014.
22. Innate immune response induced by baculovirus attenuates transgene expression in Mammalian cells.

    Chikako Ono, Akinori Ninomiya, Satomi Yamamoto, Takayuki Abe, Xiauyu Wen, Takasuke Fukuhara, Miwa Sasai, Masahiro Yamamoto, Tatsuya Saitoh, Takashi Satoh, Taro Kawai, Ken J Ishii, Shizuo Akira, Toru Okamoto and Yoshiharu Matsuura

    J Virol, 88 (4), 2157-2167, 2014.
23. Roles of microsomal prostaglandin E synthase-1 in lung metastasis formation in prostate cancer RM9 cells.

    R Takahashi, H Amano, T Satoh, K Tabata, M Ikeda, H Kitasato, S Akira, M Iwamura and M Majima

    Biomed Pharmacother, 68 (1), 71-77, 2014.
24. RAE1 ligands for the NKG2D receptor are regulated by STING-dependent DNA sensor pathways in lymphoma.

    Adeline R Lam, Nina Le Bert, Samantha S W Ho, Yu J Shen, Melissa L F Tang, Gordon M Xiong, J Ludovic Croxford, Christine X Koo, Ken J Ishii, Shizuo Akira, David H Raulet and Stephan Gasser

    Cancer Res, 74 (8), 2193-2203, 2014.
25. Role of Mouse and Human Autophagy Proteins in IFN-γ-Induced Cell-Autonomous Responses against Toxoplasma gondii.

    Jun Ohshima, Youngae Lee, Miwa Sasai, Tatsuya Saitoh, Ji Su Ma, Naganori Kamiyama, Yoshiharu Matsuura, Suh Pann-Ghill, Mikako Hayashi, Shigeyuki Ebisu, Kiyoshi Takeda, Shizuo Akira and Masahiro Yamamoto

    J Immunol, 192 (7), 3328-3335, 2014.
26. TRIF Signaling Is Essential for TLR4-Driven IgE Class Switching.

    Erin Janssen, Esra Ozcan, Kyriaki Liadaki, Haifa H Jabara, John Manis, Sumana Ullas, Shizuo Akira, Katherine A Fitzgerald, Douglas T Golenbock and Raif S Geha

    J Immunol, 192 (6), 2651-2658, 2014.
27. Prevention of intestinal allergy in mice by rflaA:Ova is associated with enforced antigen processing and TLR5-dependent IL-10 secretion by mDC.

    Stefan Schülke, Sonja Wolfheimer, Gabriele Gadermaier, Andrea Wangorsch, Susanne Siebeneicher, Peter Briza, Ingo Spreitzer, Dirk Schiller, Bettina Loeschner, Satoshi Uematsu, Bernard Ryffel, Shizuo Akira, Zoe Waibler, Stefan Vieths, Masako Toda and Stephan Scheurer

    PLoS One, 9 (2), e87822, 2014.
28. Nonagonistic Dectin-1 ligand transforms CpG into a multitask nanoparticulate TLR9 agonist.

    Kouji Kobiyama, Taiki Aoshi, Hirotaka Narita, Etsushi Kuroda, Masayuki Hayashi, Kohhei Tetsutani, Shohei Koyama, Shinichi Mochizuki, Kazuo Sakurai, Yuko Katakai, Yasuhiro Yasutomi, Shinobu Saijo, Yoichiro Iwakura, Shizuo Akira, Cevayir Coban and Ken J Ishii

    Proc Natl Acad Sci U S A, 111 (8), 3086-3091, 2014.
29. Protective role for Toll-like receptor-9 in the development of atherosclerosis in apolipoprotein E-deficient mice.

    Christine Koulis, Yung-Chih Chen, Christian Hausding, Ingo Ahrens, Tin Soe Kyaw, Christopher Tay, Terri Allen, Karin Jandeleit-Dahm, Matthew J Sweet, Shizuo Akira, Alexander Bobik, Karlheinz Peter and Alex Agrotis

    Arterioscler Thromb Vasc Biol, 34 (3), 516-525, 2014.
30. Tribbles homolog 3 attenuates mammalian target of rapamycin complex-2 signaling and inflammation in the diabetic kidney.

    Emily Borsting, Shalin V Patel, Anne-Emilie Declèves, Sarah J Lee, Qazi M Rahman, Shizuo Akira, Joe Satriano, Kumar Sharma, Volker Vallon and Robyn Cunard

    J Am Soc Nephrol, 25 (9), 2067-2078, 2014.
31. Intrinsic disorder mediates cooperative signal transduction in STIM1.

    Yukio Furukawa, Shunsuke Teraguchi, Takahisa Ikegami, Onur Dagliyan, Lin Jin, Damien Hall, Nikolay V Dokholyan, Keiichi Namba, Shizuo Akira, Tomohiro Kurosaki, Yoshihiro Baba and Daron M Standley

    J Mol Biol, 426 (10), 2082-2097, 2014.
32. Humoral Immunity and CD4+ Th1 Cells Are Both Necessary for a Fully Protective Immune Response upon Secondary Infection with Brucella melitensis.

    Marie-Alice Vitry, Delphine Hanot Mambres, Carl De Trez, Shizuo Akira, Bernhard Ryffel, Jean-Jacques Letesson and Eric Muraille

    J Immunol, 192 (8), 3740-3752, 2014.
33. Blockade of TLR3 protects mice from lethal radiation-induced gastrointestinal syndrome.

    Naoki Takemura, Takumi Kawasaki, Jun Kunisawa, Shintaro Sato, Aayam Lamichhane, Kouji Kobiyama, Taiki Aoshi, Junichi Ito, Kenji Mizuguchi, Thangaraj Karuppuchamy, Kouta Matsunaga, Shoichiro Miyatake, Nobuko Mori, Tohru Tsujimura, Takashi Satoh, Yutaro Kumagai, Taro Kawai, Daron M Standley, Ken J Ishii, Hiroshi Kiyono, Shizuo Akira and Satoshi Uematsu

    Nat Commun, 5, 3492, 2014.
34. The proapoptotic BH3-only proteins Bim and Puma are downstream of endoplasmic reticulum and mitochondrial oxidative stress in pancreatic islets in response to glucotoxicity.

    J A Wali, D Rondas, M D McKenzie, Y Zhao, L Elkerbout, S Fynch, E N Gurzov, S Akira, C Mathieu, T W H Kay, L Overbergh, A Strasser and H E Thomas

    Cell Death Dis, 5, e1124, 2014.

Link

Department of Host Defense

Research Institute for Microbial Diseases, Osaka University