Laboratory of Combined Research on Microbiology and Immunology

Staff:

Associate Professor

Hiroki Nagai, Ph.D.

Specially Appointed Associate Professor

Tomoko Kubori, Ph.D.

Specially Appointed Researcher

Andree M. Hubber, Ph.D.

Xuan Thanh Bui, Ph.D.

Subjects:

1. Structural analysis of effector transport machinery
2. Molecular analysis of mammalian host manipulation by Legionella sp.
3. Molecular analysis of natural host manipulation by Legionella sp.

Papers published in 2014

1. Hijacking the host proteasome for the temporal degradation of bacterial effectors.

   Tomoko Kubori, Andree M Hubber and Hiroki Nagai

   Methods Mol Biol, 1197, 141-152, 2014.
2. Native structure of a type IV secretion system core complex essential for Legionella pathogenesis.

   Tomoko Kubori, Masafumi Koike, Xuan Thanh Bui, Saori Higaki, Shin-Ichi Aizawa and Hiroki Nagai

   Proc Natl Acad Sci U S A, 111 (32), 11804-11809, 2014.
3. The machinery at endoplasmic reticulum-plasma membrane contact sites contributes to spatial regulation of multiple legionella effector proteins.

   Andree Hubber, Kohei Arasaki, Fubito Nakatsu, Camille Hardiman, David Lambright, Pietro De Camilli, Hiroki Nagai and Craig R Roy

   PLoS Pathog, 10 (7), e1004222, 2014.
4. Amoebal endosymbiont Neochlamydia genome sequence illuminates the bacterial role in the defense of the host amoebae against Legionella pneumophila.

   Kasumi Ishida, Tsuyoshi Sekizuka, Kyoko Hayashida, Junji Matsuo, Fumihiko Takeuchi, Makoto Kuroda, Shinji Nakamura, Tomohiro Yamazaki, Mitsutaka Yoshida, Kaori Takahashi, Hiroki Nagai, Chihiro Sugimoto and Hiroyuki Yamaguchi

   PLoS One, 9 (4), e95166, 2014.

Link

Laboratory of Combined Research on Microbiology and Immunology(Nagai Group)

Research Institute for Microbial Diseases, Osaka University