Laboratory of Clinical Research Infectious Diseases 2

Staff:

Guest Professor

Kazunori Oishi, M.D., Ph.D.

Specially Appointed Associate Professor

Yukihiro Akeda, Ph.D.

Specially Appointed Researcher

Zhenyu Piao, M.D., Ph.D.

Dan Takeuchi, M.D., Ph.D.

Subjects:

1. Vaccines for pneumococci and Haemophilus influenzae
2. Streptococcus suis infection
3. Drug resistant bacteria

Papers published in 2014

1. Presence of neutrophil extracellular traps and citrullinated histone h3 in the bloodstream of critically ill patients.

   Tomoya Hirose, Shigeto Hamaguchi, Naoya Matsumoto, Taro Irisawa, Masafumi Seki, Osamu Tasaki, Hideo Hosotsubo, Norihisa Yamamoto, Kouji Yamamoto, Yukihiro Akeda, Kazunori Oishi, Kazunori Tomono and Takeshi Shimazu

   PLoS One, 9 (11), e111755, 2014.
2. Global Control of Pneumococcal Infections by Pneumococcal Vaccines.

   Kazunori Oishi, Kazuyo Tamura and Yukihiro Akeda

   Trop Med Health, 42 (2 Suppl), 83-86, 2014.
3. IgG levels against 13-valent pneumococcal conjugate vaccine serotypes in non pneumococcal conjugate vaccine immunized healthy Japanese and intravenous immunoglobulin preparations.

   Yoshiko Takahashi, Naruhiko Ishiwada, Haruka Hishiki, Junko Tanaka, Yukihiro Akeda, Naoki Shimojo, Kazunori Oishi and Yoichi Kohno

   J Infect Chemother, 20 (12), 794-798, 2014.
4. A Bivalent Vaccine Based on a Replication-Incompetent Influenza Virus Protects against Streptococcus pneumoniae and Influenza Virus Infection.

   Hiroaki Katsura, Zhenyu Piao, Kiyoko Iwatsuki-Horimoto, Yukihiro Akeda, Shinji Watanabe, Taisuke Horimoto, Kazunori Oishi and Yoshihiro Kawaoka

   J Virol, 88 (22), 13410-13417, 2014.
5. Protective properties of a fusion pneumococcal surface protein A (PspA) vaccine against pneumococcal challenge by five different PspA clades in mice.

   Zhenyu Piao, Yukihiro Akeda, Dan Takeuchi, Ken J Ishii, Kimiko Ubukata, David E Briles, Kazunori Tomono and Kazunori Oishi

   Vaccine, 32 (43), 5607-5613, 2014.
6. A human case of Streptococcus suis infection caused by an unencapsulated strain

   A Kerdsin, D Takeuchi, M Gottschalk, S Hamada, Y Akeda and K Oishi

   JMM Case Reports, 1 (2), , 2014.
7. Colloidal gold-based immunochromatographic strip test compromising optimised combinations of anti-S. suis capsular polysaccharide polyclonal antibodies for detection of Streptococcus suis.

   Tatsuya Nakayama, Jizi Zhao, Dan Takeuchi, Anusack Kerdsin, Piphat Chiranairadul, Prasanee Areeratana, Phacharaphan Loetthong, Anupong Pienpringam, Yukihiro Akeda and Kazunori Oishi

   Biosens Bioelectron, 60, 175-179, 2014.
8. Streptococcus suis serotyping by a new multiplex PCR.

   Anusak Kerdsin, Yukihiro Akeda, Rujirat Hatrongjit, Unchaya Detchawna, Tsutomu Sekizaki, Shigeyuki Hamada, Marcelo Gottschalk and Kazunori Oishi

   J Med Microbiol, 63 (Pt 6), 824-830, 2014.
9. The contribution of suilysin to the pathogenesis of Streptococcus suis meningitis.

   Dan Takeuchi, Yukihiro Akeda, Tatsuya Nakayama, Anusak Kerdsin, Yasuteru Sano, Takashi Kanda, Shigeyuki Hamada, Surang Dejsirilert and Kazunori Oishi

   J Infect Dis, 209 (10), 1509-1519, 2014.
10. Neutrophil extracellular traps in bronchial aspirates: a quantitative analysis.

    Shigeto Hamaguchi, Tomoya Hirose, Naoya Matsumoto, Yukihiro Akeda, Taro Irisawa, Masafumi Seki, Hideo Hosotsubo, Kouji Yamamoto, Osamu Tasaki, Kazunori Oishi, Takeshi Shimazu and Kazunori Tomono

    Eur Respir J, 43 (6), 1709-1718, 2014.
11. Hyporesponsiveness to the infecting serotype after vaccination of children with seven-valent pneumococcal conjugate vaccine following invasive pneumococcal disease.

    Kazuyo Tamura, Kousaku Matsubara, Naruhiko Ishiwada, Junichiro Nishi, Hidenori Ohnishi, Shigeru Suga, Toshiaki Ihara, Bin Chang, Yukihiro Akeda and Kazunori Oishi et al.

    Vaccine, 32 (13), 1444-1450, 2014.
12. The Vibrio parahaemolyticus effector VopC mediates Cdc42-dependent invasion of cultured cells but is not required for pathogenicity in an animal model of infection.

    Ryu Okada, Xiaohui Zhou, Hirotaka Hiyoshi, Shigeaki Matsuda, Xiang Chen, Yukihiro Akeda, Takashige Kashimoto, Brigid M Davis, Tetsuya Iida, Matthew K Waldor and Toshio Kodama

    Cell Microbiol, 16 (6), 938-947, 2014.
13. Sustained functional serotype-specific antibody after primary and secondary vaccinations with a pneumococcal polysaccharide vaccine in elderly patients with chronic lung disease.

    Nobuharu Ohshima, Hideaki Nagai, Hirotoshi Matsui, Shunsuke Akashi, Tomohiko Makino, Yukihiro Akeda and Kazunori Oishi

    Vaccine, 32 (10), 1181-1186, 2014.

Link

Laboratory for Clinical Research on Infectious Diseases 2

Research Institute for Microbial Diseases, Osaka University