Department of Celluar Regulation

Staff:

Professor

Hiroaki Miki, Ph.D.

Assistant Professor

Daisuke Yamazaki, Ph.D.

Yosuke Funato, Ph.D.

Specially Appointed Researcher

Kanami Uesugi, Ph.D.

Yusuke Hirata, Ph.D.

Graduate Student

Tasuku Ishii

Takemichi Kasashima

Kei Sawaragi

Nao Arita

Takeru Yamaguchidani

1. Mechanism of intestinal magnesium absorption via CNNM4
2. Mechanism of renal magnesium reabsorption via CNNM2
3. Mechanism of cancer progression by suppressing magnesium transport

1. Membrane protein CNNM4-dependent Mg2+ efflux suppresses tumor progression.

   Yosuke Funato, Daisuke Yamazaki, Shin Mizukami, Lisa Du, Kazuya Kikuchi and Hiroaki Miki

   J Clin Invest, 124 (12), 5398-5410, 2014.
2. Basolateral sorting of the Mg²⁺ transporter CNNM4 requires interaction with AP-1A and AP-1B.

   Yusuke Hirata, Yosuke Funato and Hiroaki Miki

   Biochem Biophys Res Commun, 455 (3-4), 184-189, 2014.
3. Reconstruction of insulin signal flow from phosphoproteome and metabolome data.

   Katsuyuki Yugi, Hiroyuki Kubota, Yu Toyoshima, Rei Noguchi, Kentaro Kawata, Yasunori Komori, Shinsuke Uda, Katsuyuki Kunida, Yoko Tomizawa, Yosuke Funato, Hiroaki Miki, Masaki Matsumoto, Keiichi I Nakayama, Kasumi Kashikura, Keiko Endo, Kazutaka Ikeda, Tomoyoshi Soga and Shinya Kuroda

   Cell Rep, 8 (4), 1171-1183, 2014.
4. Mg2+-dependent Interactions of ATP with the Cystathionine-β-Synthase (CBS) Domains of a Magnesium Transporter.

   Yusuke Hirata, Yosuke Funato, Yu Takano and Hiroaki Miki

   J Biol Chem, 289 (21), 14731-14739, 2014.
5. Reversible oxidation of PRL family protein-tyrosine phosphatases.

   Yosuke Funato and Hiroaki Miki

   Methods, 65 (2), 184-189, 2014.

Link

Department of Cellular Regulation

Research Institute for Microbial Diseases, Osaka University