Department of Signal Transduction

Staff:

Professor

Nobuyuki Takakura, M.D., Ph.D.

Assistant Professor

Hiroyasu Kidoya, Ph.D.

Hisamichi Naito, M.D., Ph.D.

Specially Appointed Researcher

Yumi Kinugasa, Ph.D.

Yinglu Han, Ph.D.

Tomomi Mohri, Ph.D.

Daishi Yamakawa, Ph.D.

Weizhen Jia, Ph.D.

Chie Takeshita

Graduate Student

Takahiro Matsui

Taku Wakabayashi

Kazuhiro Takara

Hiroki Kawahara

Gong Zhiyuan

Mika Sawane

Yuji Satoh

Zhang Li

Ryu Kanzaki

Fumitaka Muramatsu

Keitaro Yamane

Tomoko Kosaka

Hironori Yoshida

Miku Kitta

Yumiko Hayashi

Shoko Hosojima

Research Student

Nobuaki Ooto

Subjects:

1. Elucidation of the tube-forming mechanism by investigating the polarity of ECs.
2. Analysis of the functional role(s) of Tie2 and down stream of Tie2 in the maturation of blood vessels.
3. Analysis of hematopoietic cells in angiogenesis.
4. Analysis of specification between artery and vein.
5. Analysis of stem cell system in blood vessels.
6. Functional analysis of GINS complex and galectin-3 in stem cells.

Papers published in 2013

1. Regulation of niche molecules for the maintenance of cardiac stem cells.

   Nobuyuki Takakura

   Circ J, 78 (1), 69-70, 2013.
2. Heregulin induces resistance to lapatinib-mediated growth inhibition of HER2-amplified cancer cells.

   Yuji Sato, Masakazu Yashiro and Nobuyuki Takakura

   Cancer Sci, 104 (12), 1618-1625, 2013.
3. Development of novel DNA vaccine for VEGF in murine cancer model.

   Mariko Kyutoku, Hironori Nakagami, Hiroshi Koriyama, Hideki Tomioka, Futoshi Nakagami, Munehisa Shimamura, Hitomi Kurinami, Pang Zhengda, Dong Hyun Jo, Jeong Hun Kim, Nobuyuki Takakura and Ryuichi Morishita

   Sci Rep, 3, 3380, 2013.
4. Requirement of SLD5 for early embryogenesis.

   Tomomi Mohri, Masaya Ueno, Yumi Nagahama, Zhi-Yuan Gong, Masahide Asano, Hiroko Oshima, Masanobu Oshima, Yasushi Fujio and Nobuyuki Takakura

   PLoS One, 8 (11), e78961, 2013.
5. Identification of vascular endothelial side population cells in the choroidal vessels and their potential role in age-related macular degeneration.

   Taku Wakabayashi, Hisamichi Naito, Kazuhiro Takara, Hiroyasu Kidoya, Susumu Sakimoto, Yusuke Oshima, Kohji Nishida and Nobuyuki Takakura

   Invest Ophthalmol Vis Sci, 54 (10), 6686-6693, 2013.
6. Tumor endothelial cell-specific drug delivery system using apelin-conjugated liposomes.

   Hiroki Kawahara, Hisamichi Naito, Kazuhiro Takara, Taku Wakabayashi, Hiroyasu Kidoya and Nobuyuki Takakura

   PLoS One, 8 (6), e65499, 2013.
7. Galectin-3 accelerates M2 macrophage infiltration and angiogenesis in tumors.

   Weizhen Jia, Hiroyasu Kidoya, Daishi Yamakawa, Hisamichi Naito and Nobuyuki Takakura

   Am J Pathol, 182 (5), 1821-1831, 2013.
8. Possible role of mural cell-covered mature blood vessels in inducing drug resistance in cancer-initiating cells.

   Takahiro Matsui, Yumi Kinugasa, Hidekazu Tahara, Yuzuru Kanakura and Nobuyuki Takakura

   Am J Pathol, 182 (5), 1790-1799, 2013.
9. Ligand-independent Tie2 dimers mediate kinase activity stimulated by high dose angiopoietin-1.

   Daishi Yamakawa, Hiroyasu Kidoya, Susumu Sakimoto, Weizhen Jia, Hisamichi Naito and Nobuyuki Takakura

   J Biol Chem, 288 (18), 12469-12477, 2013.
10. An angiogenic role for adrenomedullin in choroidal neovascularization.

    Susumu Sakimoto, Hiroyasu Kidoya, Motohiro Kamei, Hisamichi Naito, Daishi Yamakawa, Hirokazu Sakaguchi, Taku Wakabayashi, Kohji Nishida and Nobuyuki Takakura

    PLoS One, 8 (3), e58096, 2013.
11. Critical role of Trib1 in differentiation of tissue-resident M2-like macrophages.

    Takashi Satoh, Hiroyasu Kidoya, Hisamichi Naito, Masahiro Yamamoto, Naoki Takemura, Katsuhiro Nakagawa, Yoshichika Yoshioka, Eiichi Morii, Nobuyuki Takakura, Osamu Takeuchi and Shizuo Akira

    Nature, 495 (7442), 524-528, 2013.
12. Apelin inhibits diet-induced obesity by enhancing lymphatic and blood vessel integrity.

    Mika Sawane, Kentaro Kajiya, Hiroyasu Kidoya, Masaya Takagi, Fumitaka Muramatsu and Nobuyuki Takakura

    Diabetes, 62 (6), 1970-1980, 2013.
13. microRNA-125b inhibits tube formation of blood vessels through translational suppression of VE-cadherin.

    F Muramatsu, H Kidoya, H Naito, S Sakimoto and N Takakura

    Oncogene, 32 (4), 414-421, 2013.

Link

http://www.biken.osaka-u.ac.jp/