Department of Molecular Virology

Staff:

Professor

Yoshiharu Matsuura, D.V.M., Ph.D.

Assistant Professor

Toru Okamoto, Ph.D.

Takasuke Fukuhara, M.D., Ph.D.

JSPS Postdoctoral Fellowship

Hiroshi Katoh, Ph.D.

Specially Appointed Researcher

Chikako Ono, Ph.D.

Takashi Motomura, M.D.

Sayaka Aizawa, Ph.D.

Masami Wada, Ph.D.

Puig-Basagoiti Francesc, Ph.D.

Graduate Student

Akinori Ninomiya

Mai Shiokawa

Pham Ngoc Duc

Takahisa Kouwaki

Satomi Yamamoto

Takahiro Kawagishi

Eiji Hirooka

Research Student

Ryoichi Shima

Tatsuya Miyoshi

Yoshihiko Morishita

Subjects:

1. Studies on hepatitis C virus.
2. Studies on Japanese encephalitis virus.
3. Studies on hepatitis B virus.
4. Development of viral vectors.

Papers published in 2013

1. Decreased roundabout 1 expression promotes development of intrahepatic cholangiocarcinoma.

   Yohei Mano, Shinichi Aishima, Takasuke Fukuhara, Yuki Tanaka, Yuichiro Kubo, Takashi Motomura, Takeo Toshima, Tomohiro Iguchi, Ken Shirabe, Yoshihiko Maehara and Yoshinao Oda

   Hum Pathol, 44 (11), 2419-2426, 2013.
2. HoxA9 regulated Bcl-2 expression mediates survival of myeloid progenitors and the severity of HoxA9-dependent leukemia.

   Gabriela Brumatti, Marika Salmanidis, Chung H Kok, Rebecca A Bilardi, Jarrod J Sandow, Natasha Silke, Kylie Mason, Jolanda Visser, Anissa M Jabbour, Stefan P Glaser, Toru Okamoto, Philippe Bouillet, Richard J D'Andrea and Paul G Ekert

   Oncotarget, 4 (11), 1933-1947, 2013.
3. Hoxb8 regulates expression of microRNAs to control cell death and differentiation.

   M Salmanidis, G Brumatti, N Narayan, B D Green, J A van den Bergen, J J Sandow, A G Bert, N Silke, R Sladic, H Puthalakath, L Rohrbeck, T Okamoto, P Bouillet, M J Herold, G J Goodall, A M Jabbour and P G Ekert

   Cell Death Differ, 20 (10), 1370-1380, 2013.
4. Ifit1 inhibits Japanese encephalitis virus replication through binding to 5' capped 2'-O unmethylated RNA.

   Taishi Kimura, Hiroshi Katoh, Hisako Kayama, Hiroyuki Saiga, Megumi Okuyama, Toru Okamoto, Eiji Umemoto, Yoshiharu Matsuura, Masahiro Yamamoto and Kiyoshi Takeda

   J Virol, 87 (18), 9997-10003, 2013.
5. The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism.

   James M Murphy, Peter E Czabotar, Joanne M Hildebrand, Isabelle S Lucet, Jian-Guo Zhang, Silvia Alvarez-Diaz, Rowena Lewis, Najoua Lalaoui, Donald Metcalf, Andrew I Webb, Samuel N Young, Leila N Varghese, Gillian M Tannahill, Esme C Hatchell, Ian J Majewski, Toru Okamoto, Renwick C J Dobson, Douglas J Hilton, Jeffrey J Babon, Nicos A Nicola, Andreas Strasser, John Silke and Warren S Alexander

   Immunity, 39 (3), 443-453, 2013.
6. Early extensive viremia, but not rs8099917 genotype, is the only predictor for cholestatic hepatitis C after living-donor liver transplantation.

   Toru Ikegami, Ken Shirabe, Takasuke Fukuhara, Norihiro Furusyo, Kazuhiro Kotoh, Masaki Kato, Shinji Shimoda, Shinichi Aishima, Yuji Soejima, Tomoharu Yoshizumi and Yoshihiko Maehara

   Hepatol Res, 43 (6), 621-629, 2013.
7. Understanding the biological context of NS5A-host interactions in HCV infection: a network-based approach.

   Lokesh P Tripathi, Hiroto Kambara, Yi-An Chen, Yorihiro Nishimura, Kohji Moriishi, Toru Okamoto, Eiji Morita, Takayuki Abe, Yoshio Mori, Yoshiharu Matsuura and Kenji Mizuguchi

   J Proteome Res, 12 (6), 2537-2551, 2013.
8. Human blood dendritic cell antigen 3 (BDCA3)(+) dendritic cells are a potent producer of interferon-λ in response to hepatitis C virus.

   Sachiyo Yoshio, Tatsuya Kanto, Shoko Kuroda, Tokuhiro Matsubara, Koyo Higashitani, Naruyasu Kakita, Hisashi Ishida, Naoki Hiramatsu, Hiroaki Nagano, Masaya Sugiyama, Kazumoto Murata, Takasuke Fukuhara, Yoshiharu Matsuura, Norio Hayashi, Masashi Mizokami and Tetsuo Takehara

   Hepatology, 57 (5), 1705-1715, 2013.
9. Impact of conversion from pegylated interferon-α2b to interferon-α2a for treating recurrent hepatitis C after liver transplantation.

   Toru Ikegami, Ken Shirabe, Tomoharu Yoshizumi, Norihiro Furusyo, Kazuhiro Kotoh, Masaki Kato, Shinji Shimoda, Yuji Soejima, Takashi Motomura, Takasuke Fukuhara and Yoshihiko Maehara

   Transplantation, 95 (6), e38-42, 2013.
10. Stabilizing the pro-apoptotic BimBH3 helix (BimSAHB) does not necessarily enhance affinity or biological activity.

    Toru Okamoto, Kerry Zobel, Anna Fedorova, Clifford Quan, Hong Yang, Wayne J Fairbrother, David C S Huang, Brian J Smith, Kurt Deshayes and Peter E Czabotar

    ACS Chem Biol, 8 (2), 297-302, 2013.
11. Role of miR-122 and lipid metabolism in HCV infection.

    Takasuke Fukuhara and Yoshiharu Matsuura

    J Gastroenterol, 48 (2), 169-176, 2013.
12. Japanese encephalitis virus core protein inhibits stress granule formation through an interaction with Caprin-1 and facilitates viral propagation.

    Hiroshi Katoh, Toru Okamoto, Takasuke Fukuhara, Hiroto Kambara, Eiji Morita, Yoshio Mori, Wataru Kamitani and Yoshiharu Matsuura

    J Virol, 87 (1), 489-502, 2013.
13. TNF can activate RIPK3 and cause programmed necrosis in the absence of RIPK1.

    D M Moujalled, W D Cook, T Okamoto, J Murphy, K E Lawlor, J E Vince and D L Vaux

    Cell Death Dis, 4, e465, 2013.
14. Baculovirus: an insect-derived vector for diverse gene transfer applications.

    Kari J Airenne, Yu-Chen Hu, Thomas A Kost, Richard H Smith, Robert M Kotin, Chikako Ono, Yoshiharu Matsuura, Shu Wang and Seppo Ylä-Herttuala

    Mol Ther, 21 (4), 739-749, 2013.
15. Signal peptidase complex subunit 1 participates in the assembly of hepatitis C virus through an interaction with E2 and NS2.

    Ryosuke Suzuki, Mami Matsuda, Koichi Watashi, Hideki Aizaki, Yoshiharu Matsuura, Takaji Wakita and Tetsuro Suzuki

    PLoS Pathog, 9 (8), e1003589, 2013.
16. Ca(2+) /S100 proteins regulate HCV virus NS5A-FKBP8/FKBP38 interaction and HCV virus RNA replication.

    Joji Tani, Seiko Shimamoto, Kyoko Mori, Nobuyuki Kato, Kohji Moriishi, Yoshiharu Matsuura, Hiroshi Tokumitsu, Mitsumasa Tsuchiya, Tomohito Fujimoto, Kiyohito Kato, Hisaaki Miyoshi, Tsutomu Masaki and Ryoji Kobayashi

    Liver Int, 33 (7), 1008-1018, 2013.

Link

http://www.biken.osaka-u.ac.jp/