Department of Molecular Genetics

Staff:

Professor

Hiroshi Nojima, Ph.D.

Associate Professor

Norikazu Yabuta, Ph.D.

Assistant Professor (SUP)

Daisuke Okuzaki, Ph.D.

Specially Appointed Researcher

Satomi Mukai, Ph.D.

Researcher

Mayumi Mizuguchi

Research Collaborator

Daisaku Miura, Ph.D.

Graduate Student

Hirokazu Suzuki

Ayumi Okamoto

Shouichi Ohno

Kosuke Torigata

Kaori Yoshida

Yukihiro Nishikawa

Moe Fukuzawa

Yumi Ando

Towa Sasakura

Katsuma Matsuura

Kohshiro Fukushima

Subjects:

1. Molecular mechanisms regulating the cell cycle (checkpoint) in mammalian cells.
2. Molecular mechanisms modulating the malignancy of cancer cells.
3. Application of a new technique (Leuko Catch) to RNA diagnosis.

Papers published in 2013

1. Cell cycle-dependent Rho GTPase activity dynamically regulates cancer cell motility and invasion in vivo.

   Yoshinori Kagawa, Shinji Matsumoto, Yuji Kamioka, Koshi Mimori, Yoko Naito, Taeko Ishii, Daisuke Okuzaki, Naohiro Nishida, Sakae Maeda, Atsushi Naito, Junichi Kikuta, Keizo Nishikawa, Junichi Nishimura, Naotsugu Haraguchi, Ichiro Takemasa, Tsunekazu Mizushima, Masataka Ikeda, Hirofumi Yamamoto, Mitsugu Sekimoto, Hideshi Ishii, Yuichiro Doki, Michiyuki Matsuda, Akira Kikuchi, Masaki Mori and Masaru Ishii

   PLoS One, 8 (12), e83629, 2013.
2. Ficolin-1 is up-regulated in leukocytes and glomeruli from microscopic polyangiitis patients.

   Eri Muso, Daisuke Okuzaki, Shigeto Kobayashi, Yukako Iwasaki, Minami A Sakurai, Akihiko Ito and Hiroshi Nojima

   Autoimmunity, 46 (8), 513-524, 2013.
3. Increased Th17-inducing activity of CD14+ CD163 low myeloid cells in intestinal lamina propria of patients with Crohn's disease.

   Takayuki Ogino, Junichi Nishimura, Soumik Barman, Hisako Kayama, Satoshi Uematsu, Daisuke Okuzaki, Hideki Osawa, Naotsugu Haraguchi, Mamoru Uemura, Taishi Hata, Ichiro Takemasa, Tsunekazu Mizushima, Hirofumi Yamamoto, Kiyoshi Takeda, Yuichiro Doki and Masaki Mori

   Gastroenterology, 145 (6), 1380-91.e1, 2013.
4. MiR-424/503-mediated Rictor upregulation promotes tumor progression.

   Chitose Oneyama, Yoriko Kito, Rei Asai, Jun-ichiro Ikeda, Takuya Yoshida, Daisuke Okuzaki, Rie Kokuda, Kyoko Kakumoto, Ken-ichi Takayama, Satoshi Inoue, Eiichi Morii and Masato Okada

   PLoS One, 8 (11), e80300, 2013.
5. Lats2 phosphorylates p21/CDKN1A after UV irradiation and regulates apoptosis.

   Hirokazu Suzuki, Norikazu Yabuta, Nobuhiro Okada, Kosuke Torigata, Yael Aylon, Moshe Oren and Hiroshi Nojima

   J Cell Sci, 126 (Pt 19), 4358-4368, 2013.
6. CAWS administration increases the expression of interferon γ and complement factors that lead to severe vasculitis in DBA/2 mice.

   Noriko Nagi-Miura, Daisuke Okuzaki, Kosuke Torigata, Minami A Sakurai, Akihiko Ito, Naohito Ohno and Hiroshi Nojima

   BMC Immunol, 14, 44, 2013.
7. Human TREX component Thoc5 affects alternative polyadenylation site choice by recruiting mammalian cleavage factor I.

   Jun Katahira, Daisuke Okuzaki, Hitomi Inoue, Yoshihiro Yoneda, Kazumitsu Maehara and Yasuyuki Ohkawa

   Nucleic Acids Res, 41 (14), 7060-7072, 2013.
8. Recruitment of cyclin G2 to promyelocytic leukemia nuclear bodies promotes dephosphorylation of γH2AX following treatment with ionizing radiation.

   Yoko Naito, Norikazu Yabuta, Jun Sato, Shouichi Ohno, Muneki Sakata, Takashi Kasama, Masahito Ikawa and Hiroshi Nojima

   Cell Cycle, 12 (11), 1773-1784, 2013.
9. Genetic analysis of genes causing hypertension and stroke in spontaneously hypertensive rats.

   Hideyuki Yamamoto, Daisuke Okuzaki, Kyosuke Yamanishi, Yunfeng Xu, Yuko Watanabe, Momoko Yoshida, Akifumi Yamashita, Naohisa Goto, Seiji Nishiguchi, Kazunori Shimada, Hiroshi Nojima, Teruo Yasunaga, Haruki Okamura, Hisato Matsunaga and Hiromichi Yamanishi

   Int J Mol Med, 31 (5), 1057-1065, 2013.
10. Yes-associated protein isoform 1 (Yap1) promotes cardiomyocyte survival and growth to protect against myocardial ischemic injury.

    Dominic P Del Re, Yanfei Yang, Noritsugu Nakano, Jaeyeaon Cho, Peiyong Zhai, Takanobu Yamamoto, Nailing Zhang, Norikazu Yabuta, Hiroshi Nojima, Duojia Pan and Junichi Sadoshima

    J Biol Chem, 288 (6), 3977-3988, 2013.
11. N-terminal truncation of Lats1 causes abnormal cell growth control and chromosomal instability.

    Norikazu Yabuta, Satomi Mukai, Ayumi Okamoto, Daisuke Okuzaki, Hirokazu Suzuki, Kosuke Torigata, Kaori Yoshida, Nobuhiro Okada, Daisaku Miura, Akihiko Ito, Masahito Ikawa, Masaru Okabe and Hiroshi Nojima

    J Cell Sci, 126 (Pt 2), 508-520, 2013.

Link

http://www.biken.osaka-u.ac.jp/