Department of Immunoregulation

Staff:

Professor(SUP)

Taroh Kinoshita, Ph.D.

Associate Professor

Yusuke Maeda, M.D., Ph.D.

Associate Professor(SUP)

Yoshiko Murakami, M.D., Ph.D.

Assistant Professor

Morihisa Fujita, Ph.D.

Specially Appointed Assistant Professor

Noriyuki Kanzawa, Ph.D.

Specially Apointed Researcher(SUP)

Jihyoun Seong,Ph.D.

Graduate Student

Gun Hee Lee

Tetsuya Hirata

Research Student

Keiko Kinoshita

Romina Theiler

Subjects:

1. Biochemistry and molecular biology of biosynthesis pathway of GPI-anchored proteins.
2. Molecular pathogenesis of a GPI-anchor deficiencies, paroxysmal nocturnal hemoglobinuria and inherited GPI deficiency.
3. pH regulation and its biological significance in acidic organelles.

Papers published in 2013

1. Transport of glycosylphosphatidylinositol-anchored proteins from the endoplasmic reticulum.

   Taroh Kinoshita, Yusuke Maeda and Morihisa Fujita

   Biochim Biophys Acta, 1833 (11), 2473-2478, 2013.
2. Long-term efficacy and safety of eculizumab in Japanese patients with PNH: AEGIS trial.

   Yuzuru Kanakura, Kazuma Ohyashiki, Tsutomu Shichishima, Shinichiro Okamoto, Kiyoshi Ando, Haruhiko Ninomiya, Tatsuya Kawaguchi, Shinji Nakao, Hideki Nakakuma, Jun-ichi Nishimura, Taroh Kinoshita, Camille L Bedrosian, Keiya Ozawa and Mitsuhiro Omine

   Int J Hematol, 98 (4), 406-416, 2013.
3. Vitamin B6-responsive epilepsy due to inherited GPI deficiency.

   Ichiro Kuki, Yukitoshi Takahashi, Shin Okazaki, Hisashi Kawawaki, Eiji Ehara, Norimitsu Inoue, Taroh Kinoshita and Yoshiko Murakami

   Neurology, 81 (16), 1467-1469, 2013.
4. A case of paroxysmal nocturnal hemoglobinuria caused by a germline mutation and a somatic mutation in PIGT.

   Peter M Krawitz, Britta Höchsmann, Yoshiko Murakami, Britta Teubner, Ulrike Krüger, Eva Klopocki, Heidemarie Neitzel, Alexander Hoellein, Christina Schneider, Dmitri Parkhomchuk, Jochen Hecht, Peter N Robinson, Stefan Mundlos, Taroh Kinoshita and Hubert Schrezenmeier

   Blood, 122 (7), 1312-1315, 2013.
5. Significance of glycosylphosphatidylinositol-anchored protein enrichment in lipid rafts for the control of autoimmunity.

   Yetao Wang, Yoshiko Murakami, Teruhito Yasui, Shigeharu Wakana, Hitoshi Kikutani, Taroh Kinoshita and Yusuke Maeda

   J Biol Chem, 288 (35), 25490-25499, 2013.
6. Glycosylphosphatidylinositol mannosyltransferase II is the rate-limiting enzyme in glycosylphosphatidylinositol biosynthesis under limited dolichol-phosphate mannose availability.

   Tetsuya Hirata, Morihisa Fujita, Noriyuki Kanzawa, Yoshiko Murakami, Yusuke Maeda and Taroh Kinoshita

   J Biochem, 154 (3), 257-264, 2013.
7. Hypomorphic mutations in PGAP2, encoding a GPI-anchor-remodeling protein, cause autosomal-recessive intellectual disability.

   Lars Hansen, Hasan Tawamie, Yoshiko Murakami, Yuan Mang, Shoaib ur Rehman, Rebecca Buchert, Stefanie Schaffer, Safia Muhammad, Mads Bak, Markus M Nöthen, Eric P Bennett, Yusuke Maeda, Michael Aigner, André Reis, Taroh Kinoshita, Niels Tommerup, Shahid Mahmood Baig and Rami Abou Jamra

   Am J Hum Genet, 92 (4), 575-583, 2013.
8. PGAP2 mutations, affecting the GPI-anchor-synthesis pathway, cause hyperphosphatasia with mental retardation syndrome.

   Peter M Krawitz, Yoshiko Murakami, Angelika Rieß, Marja Hietala, Ulrike Krüger, Na Zhu, Taroh Kinoshita, Stefan Mundlos, Jochen Hecht, Peter N Robinson and Denise Horn

   Am J Hum Genet, 92 (4), 584-589, 2013.
9. Critical roles for lipomannan and lipoarabinomannan in cell wall integrity of mycobacteria and pathogenesis of tuberculosis.

   Takeshi Fukuda, Takayuki Matsumura, Manabu Ato, Maho Hamasaki, Yukiko Nishiuchi, Yoshiko Murakami, Yusuke Maeda, Tamotsu Yoshimori, Sohkichi Matsumoto, Kazuo Kobayashi, Taroh Kinoshita and Yasu S Morita

   MBio, 4 (1), e00472-00412, 2013.
10. Implications of lipid moiety in oligomerization and immunoreactivities of GPI-anchored proteins.

    Jihyoun Seong, Yetao Wang, Taroh Kinoshita and Yusuke Maeda

    J Lipid Res, 54 (4), 1077-1091, 2013.
11. Occupancy of whole blood cells by a single PIGA-mutant clone with HMGA2 amplification in a paroxysmal nocturnal haemoglobinuria patient having blood cells with NKG2D ligands.

    Nobuyoshi Hanaoka, Yoshiko Murakami, Masahide Nagata, Kentaro Horikawa, Shoichi Nagakura, Yuji Yonemura, Shogo Murata, Takashi Sonoki, Taroh Kinoshita and Hideki Nakakuma

    Br J Haematol, 160 (1), 114-116, 2013.

Link

http://www.biken.osaka-u.ac.jp/