Department of Immunochemistry

Staff:

Professor(SUP)

Hisashi Arase, M.D., Ph.D.

Assistant Professor(SUP)

Tadahiro Suenaga, M.D., Ph.D.

Masako Kohyama, Ph.D.

Specially Appointed Researcher

Fumiji Saito, Ph.D.

Jing Wang

Visiting Researcher

Kenji Tanimura

Graduate Student

Fuminori Arisawa

Hui Jin, Ph.D.

Kazuki Kishida

Subjects:

1. Molecular mechanisms of autoimmune disease.
2. Role of paired receptors in host-pathogen interaction.
3. Mechanism of virus entry into cells.

Papers published in 2013

1. Herpesvirus 6 glycoproteins B (gB), gH, gL, and gQ are necessary and sufficient for cell-to-cell fusion.

   Yuki Tanaka, Tadahiro Suenaga, Misako Matsumoto, Tsukasa Seya and Hisashi Arase

   J Virol, 87 (19), 10900-10903, 2013.
2. Overcoming chemoresistance of small-cell lung cancer through stepwise HER2-targeted antibody-dependent cell-mediated cytotoxicity and VEGF-targeted antiangiogenesis.

   Toshiyuki Minami, Takashi Kijima, Satoshi Kohmo, Hisashi Arase, Yasushi Otani, Izumi Nagatomo, Ryo Takahashi, Kotaro Miyake, Masayoshi Higashiguchi, Osamu Morimura, Shoichi Ihara, Kazuyuki Tsujino, Haruhiko Hirata, Koji Inoue, Yoshito Takeda, Hiroshi Kida, Isao Tachibana and Atsushi Kumanogoh

   Sci Rep, 3, 2669, 2013.
3. Us3 kinase encoded by herpes simplex virus 1 mediates downregulation of cell surface major histocompatibility complex class I and evasion of CD8+ T cells.

   Takahiko Imai, Naoto Koyanagi, Ryo Ogawa, Keiko Shindo, Tadahiro Suenaga, Ayuko Sato, Jun Arii, Akihisa Kato, Hiroshi Kiyono, Hisashi Arase and Yasushi Kawaguchi

   PLoS One, 8 (8), e72050, 2013.
4. CD1a-positive familial cutaneous mastocytosis without germ-line or somatic mutations in c-kit.

   N Arase, M Wataya-Kaneda, N Oiso, H Arase and I Katayama

   Br J Dermatol, 169 (1), 201-204, 2013.
5. Neutrophil infiltration during inflammation is regulated by PILRα via modulation of integrin activation.

   Jing Wang, Ikuo Shiratori, Junji Uehori, Masahito Ikawa and Hisashi Arase

   Nat Immunol, 14 (1), 34-40, 2013.
6. Transport of misfolded endoplasmic reticulum proteins to the cell surface by MHC class II molecules.

   Yan Jiang, Noriko Arase, Masako Kohyama, Kouyuki Hirayasu, Tadahiro Suenaga, Hui Jin, Maki Matsumoto, Kyoko Shida, Lewis L Lanier, Takashi Saito and Hisashi Arase

   Int Immunol, 25 (4), 235-246, 2013.

Link

http://www.biken.osaka-u.ac.jp/