BIKEN Endowed Department of Dengue Vaccine Development

Staff:

Endowed Chair Professor

Eiji Konishi, Ph.D.

Endowed Assistant Professor

Atsushi Yamanaka, Ph.D.

Subjects:

1. Development of dengue vaccine candidates
2. Analysis of dengue-induced antibodies

Paper published in 2013

1. A mouse monoclonal antibody against dengue virus type 1 Mochizuki strain targeting envelope protein domain II and displaying strongly neutralizing but not enhancing activity.

   Atsushi Yamanaka, Tomohiro Kotaki and Eiji Konishi

   J Virol, 87 (23), 12828-12837, 2013.
2. Comparison of infection-neutralizing and -enhancing antibody balance induced by two distinct genotype strains of dengue virus type 1 or 3 DNA vaccines in mice.

   Fithriyah Sjatha, Yamato Takizawa, Tomohiro Kotaki, Atsushi Yamanaka and Eiji Konishi

   Microbes Infect, 15 (12), 828-836, 2013.
3. Genetic and evolutionary analysis of cell-fusing agent virus based on Thai strains isolated in 2008 and 2012.

   Atsushi Yamanaka, Supatra Thongrungkiat, Pongrama Ramasoota and Eiji Konishi

   Infect Genet Evol, 19, 188-194, 2013.
4. Correlation between complement component levels and disease severity in dengue patients in Indonesia.

   Atsushi Yamanaka, Eryk Hendrianto, Kris C Mulyatno, Helen Susilowati, Amor P Ginting, Dian D Sary, Soegeng Soegijanto and Eiji Konishi

   Jpn J Infect Dis, 66 (5), 366-374, 2013.
5. Memory B cells: a proposed new immunological correlate for protective efficacy of Japanese encephalitis vaccine.

   Eiji Konishi

   Expert Rev Vaccines, 12 (8), 871-873, 2013.
6. Production of Japanese encephalitis virus-like particles in insect cells.

   Hideki Yamaji and Eiji Konishi

   Bioengineered, 4 (6), 438-442, 2013.
7. Efficient production of Japanese encephalitis virus-like particles by recombinant lepidopteran insect cells.

   Hideki Yamaji, Masataka Nakamura, Miwa Kuwahara, Yusuke Takahashi, Tomohisa Katsuda and Eiji Konishi

   Appl Microbiol Biotechnol, 97 (3), 1071-1079, 2013.

Link

http://www.biken.osaka-u.ac.jp/