Department of Signal Transduction

Subjects:

1. Elucidation of the tube-forming mechanism by investigating the polarity of ECs.
2. Analysis of the functional role(s) of Tie2 and down stream of Tie2 in the maturation of blood vessels.
3. Analysis of hematopoietic cells in angiogenesis.
4. Analysis of specification between artery and vein.
5. Analysis of stem cell system in blood vessels.
6. Functional analysis of GINS complex and galectin-3 in stem cells.

Papers published in 2012

1. Formation and regulation of the cancer stem cell niche.

   Nobuyuki Takakura

   Cancer Sci, 103 (7), 1177-1181, 2012.
2. A role for endothelial cells in promoting the maturation of astrocytes through the apelin/APJ system in mice.

   Susumu Sakimoto, Hiroyasu Kidoya, Hisamichi Naito, Motohiro Kamei, Hirokazu Sakaguchi, Nobuhito Goda, Akiyoshi Fukamizu, Kohji Nishida and Nobuyuki Takakura

   Development, 139 (7), 1327-1335, 2012.
3. Involvement of non-vascular stem cells in blood vessel formation.

   Nobuyuki Takakura

   Int J Hematol, 95 (2), 138-142, 2012.
4. Guest editorial: mutual relationship between vascular biology and hematology.

   Nobuyuki Takakura

   Int J Hematol, 95 (2), 117-118, 2012.
5. Promotion of Lymphatic Integrity by Angiopoietin-1/Tie2 Signaling during Inflammation.

   Kentaro Kajiya, Hiroyasu Kidoya, Mika Sawane, Yuuko Matsumoto-Okazaki, Haruyo Yamanishi, Mikio Furuse and Nobuyuki Takakura

   Am J Pathol, 180 (3), 1273-1282, 2012.
6. Changes in blood vessel maturation in the fibrous cap of the tumor rim.

   Hisamichi Naito, Kazuhiro Takara, Taku Wakabayashi, Hiroki Kawahara, Hiroyasu Kidoya and Nobuyuki Takakura

   Cancer Sci, 103 (3), 433-438, 2012.
7. The apelin/APJ system induces maturation of the tumor vasculature and improves the efficiency of immune therapy.

   H Kidoya, N Kunii, H Naito, F Muramatsu, Y Okamoto, T Nakayama and N Takakura

   Oncogene, 31 (27), 3254-3264, 2012.
8. Monoclonal antibody selectively recognizing murine but not human CD44.

   Yumi Kinugasa and Nobuyuki Takakura

   Hybridoma (Larchmt), 31 (4), 262-266, 2012.
9. Endothelial PI3K-C2α, a class II PI3K, has an essential role in angiogenesis and vascular barrier function.

   Kazuaki Yoshioka, Kotaro Yoshida, Hong Cui, Tomohiko Wakayama, Noriko Takuwa, Yasuo Okamoto, Wa Du, Xun Qi, Ken Asanuma, Kazushi Sugihara, Sho Aki, Hidekazu Miyazawa, Kuntal Biswas, Chisa Nagakura, Masaya Ueno, Shoichi Iseki, Robert J Schwartz, Hiroshi Okamoto, Takehiko Sasaki, Osamu Matsui, Masahide Asano, Ralf H Adams, Nobuyuki Takakura and Yoh Takuwa

   Nat Med, 18 (10), 1560-1569, 2012.
10. Biology of the apelin-APJ axis in vascular formation.

    Hiroyasu Kidoya and Nobuyuki Takakura

    J Biochem, 152 (2), 125-131, 2012.

Link

http://www.biken.osaka-u.ac.jp/