Department of Oncogene Research

Subjects:

1. Functions of the Src family tyrosine kinases (SFK).
2. Molecular mechanisms of SFK-mediated cell transformation.
3. Regulation of tumor growth via the endosomal compartments.

Published Papers

1. MicroRNA-mediated upregulation of integrin-linked kinase promotes Src-induced tumor progression.

   C Oneyama, E Morii, D Okuzaki, Y Takahashi, J Ikeda, N Wakabayashi, H Akamatsu, M Tsujimoto, T Nishida, K Aozasa and M Okada

   Oncogene, 31 (13), 1623-1635, 2012.
2. The guanine nucleotide exchange factor Arhgef5 plays crucial roles in Src-induced podosome formation.

   Miho Kuroiwa, Chitose Oneyama, Shigeyuki Nada and Masato Okada

   J Cell Sci, 124 (Pt 10), 1726-1738, 2011.
3. Down-regulation of the tumor suppressor C-terminal Src kinase (Csk)-binding protein (Cbp)/PAG1 is mediated by epigenetic histone modifications via the mitogen-activated protein kinase (MAPK)/phosphatidylinositol 3-kinase (PI3K) pathway.

   Kei Suzuki, Chitose Oneyama, Hironobu Kimura, Shoji Tajima and Masato Okada

   J Biol Chem, 286 (18), 15698-15706, 2011.
4. MicroRNA-mediated downregulation of mTOR/FGFR3 controls tumor growth induced by Src-related oncogenic pathways.

   C Oneyama, J Ikeda, D Okuzaki, K Suzuki, T Kanou, Y Shintani, E Morii, M Okumura, K Aozasa and M Okada

   Oncogene, 30 (32), 3489-3501, 2011.
5. The transmembrane adaptor Cbp/PAG1 controls the malignant potential of human non-small cell lung cancers that have c-src upregulation.

   Takashi Kanou, Chitose Oneyama, Kunimitsu Kawahara, Akira Okimura, Mitsunori Ohta, Naoki Ikeda, Yasushi Shintani, Meinoshin Okumura and Masato Okada

   Mol Cancer Res, 9 (1), 103-114, 2011.
6. Identification of functional domains and novel binding partners of STIM proteins.

   Norimitsu Saitoh, Kenji Oritani, Kazunobu Saito, Takafumi Yokota, Michiko Ichii, Takao Sudo, Natsuko Fujita, Koichi Nakajima, Masato Okada and Yuzuru Kanakura

   J Cell Biochem, 112 (1), 147-156, 2011.
7. Exendin-4 suppresses SRC activation and reactive oxygen species production in diabetic Goto-Kakizaki rat islets in an Epac-dependent manner.

   Eri Mukai, Shimpei Fujimoto, Hiroki Sato, Chitose Oneyama, Rieko Kominato, Yuichi Sato, Mayumi Sasaki, Yuichi Nishi, Masato Okada and Nobuya Inagaki

   Diabetes, 60 (1), 218-226, 2011.

Link

http://www.biken.osaka-u.ac.jp/