Department of Molecular Protozoology

Subjects:

1. Development of a recombinant vaccine based on the malaria protein SERA.
2. Development of a novel vaccine adjuvant and elucidation of its mechanism of action.
3. Study on host-parasite interaction of malaria infection.
4. Study on phylogeny and evolution of SERA multigene family in the genus Plasmodium.

Published Papers

1. The in silico screening and X-ray structure analysis of the inhibitor complex of Plasmodium falciparum orotidine 5'-monophosphate decarboxylase.

   Yasuhide Takashima, Eiichi Mizohata, Sudaratana R Krungkrai, Yoshifumi Fukunishi, Takayoshi Kinoshita, Tsuneaki Sakata, Hiroyoshi Matsumura, Jerapan Krungkrai, Toshihiro Horii and Tsuyoshi Inoue

   J Biochem, 152 (2), 133-138, 2012.
2. Identification of pyrimethamine- and chloroquine-resistant Plasmodium falciparum in Africa between 1984 and 1998: genotyping of archive blood samples.

   Yumiko Saito-Nakano, Kazuyuki Tanabe and Toshihiro Mita

   Malar J, 10 (1), 388, 2011.
3. The origins of African Plasmodium vivax; insights from mitochondrial genome sequencing.

   Richard Culleton, Cevayir Coban, Fadile Yildiz Zeyrek, Pedro Cravo, Akira Kaneko, Milijaona Randrianarivelojosia, Voahangy Andrianaranjaka, Shigeyuki Kano, Anna Farnert, Ana Paula Arez, Paul M Sharp, Richard Carter and Kazuyuki Tanabe

   PLoS One, 6 (12), e29137, 2011.
4. Limited geographical origin and global spread of sulfadoxine-resistant dhps alleles in Plasmodium falciparum populations.

   Toshihiro Mita, Meera Venkatesan, Jun Ohashi, Richard Culleton, Nobuyuki Takahashi, Takahiro Tsukahara, Mathieu Ndounga, Lek Dysoley, Hiroyoshi Endo, Francis Hombhanje, Marcelo U Ferreira, Christopher V Plowe and Kazuyuki Tanabe

   J Infect Dis, 204 (12), 1980-1988, 2011.
5. Identification and phylogenetic analysis of Japanese Macaque Babesia-1 (JM-1) detected from a Japanese Macaque (Macaca fuscata fuscata).

   Haruyuki Hirata, Satoru Kawai, Mari Maeda, Michio Jinnai, Kohei Fujisawa, Yuko Katakai, Kenji Hikosaka, Kazuyuki Tanabe, Yasuhiro Yasutomi and Chiaki Ishihara

   Am J Trop Med Hyg, 85 (4), 635-638, 2011.
6. Plasmodium falciparum: differential selection of drug resistance alleles in contiguous urban and peri-urban areas of Brazzaville, Republic of Congo.

   Yoko Tsumori, Mathieu Ndounga, Toshihiko Sunahara, Nozomi Hayashida, Megumi Inoue, Shusuke Nakazawa, Prisca Casimiro, Rie Isozumi, Haruki Uemura, Kazuyuki Tanabe, Osamu Kaneko and Richard Culleton

   PLoS One, 6 (8), e23430, 2011.
7. Highly conserved gene arrangement of the mitochondrial genomes of 23 Plasmodium species.

   Kenji Hikosaka, Yoh-Ichi Watanabe, Fumie Kobayashi, Seiji Waki, Kiyoshi Kita and Kazuyuki Tanabe

   Parasitol Int, 60 (2), 175-180, 2011.
8. Plasmodium ovale curtisi and Plasmodium ovale wallikeri circulate simultaneously in African communities.

   Mary Chiaka Oguike, Martha Betson, Martina Burke, Debbie Nolder, J Russell Stothard, Immo Kleinschmidt, Carla Proietti, Teun Bousema, Mathieu Ndounga, Kazuyuki Tanabe, Edward Ntege, Richard Culleton and Colin J Sutherland

   Int J Parasitol, 41 (6), 677-683, 2011.
9. Concatenated mitochondrial DNA of the coccidian parasite Eimeria tenella.

   Kenji Hikosaka, Yutaka Nakai, Yoh-Ichi Watanabe, Shin-Ichiro Tachibana, Nobuko Arisue, Nirianne Marie Q Palacpac, Tomoko Toyama, Hajime Honma, Toshihiro Horii, Kiyoshi Kita and Kazuyuki Tanabe

   Mitochondrion, 11 (2), 273-278, 2011.
10. Spontaneous mutations in the Plasmodium falciparum sarcoplasmic/ endoplasmic reticulum Ca2+-ATPase (PfATP6) gene among geographically widespread parasite populations unexposed to artemisinin-based combination therapies.

    Kazuyuki Tanabe, Sedigheh Zakeri, Nirianne Marie Q Palacpac, Manada Afsharpad, Milijaona Randrianarivelojosia, Akira Kaneko, Aung Swi Prue Marma, Toshihiro Horii and Toshihiro Mita

    Antimicrob Agents Chemother, 55 (1), 94-100, 2011.
11. Clues to Evolution of the SERA Multigene Family in 18 Plasmodium Species.

    Nobuko Arisue, Satoru Kawai, Makoto Hirai, Nirianne M Q Palacpac, Mozhi Jia, Akira Kaneko, Kazuyuki Tanabe and Toshihiro Horii

    PLoS One, 6 (3), e17775, 2011.
12. Worldwide sequence conservation of transmission-blocking vaccine candidate Pvs230 in Plasmodium vivax.

    Masanori Doi, Kazuyuki Tanabe, Shin-Ichiro Tachibana, Meiko Hamai, Mayumi Tachibana, Toshihiro Mita, Masanori Yagi, Fadile Yildiz Zeyrek, Marcelo U Ferreira, Hiroshi Ohmae, Akira Kaneko, Milijaona Randrianarivelojosia, Jetsumon Sattabongkot, Ya-Ming Cao, Toshihiro Horii, Motomi Torii and Takafumi Tsuboi

    Vaccine, 29 (26), 4308-4315, 2011.
13. Plasmodium falciparum serine repeat antigen 5 (SE36) as a malaria vaccine candidate.

    Nirianne Marie Q Palacpac, Nobuko Arisue, Takahiro Tougan, Ken J Ishii and Toshihiro Horii

    Vaccine, 29 (35), 5837-5845, 2011.
14. Recent increase of genetic diversity in Plasmodium vivax population in the Republic of Korea.

    Hajime Honma, Jung-Yeon Kim, Nirianne Mq Palacpac, Toshihiro Mita, Wonja Lee, Toshihiro Horii and Kazuyuki Tanabe

    Malar J, 10, 257, 2011.
15. Serologic Markers in Relation to Parasite Exposure History Help to Estimate Transmission Dynamics of Plasmodium vivax.

    Fadile Yildiz Zeyrek, Nirianne Palacpac, Fehmi Yuksel, Masanori Yagi, Kaori Honjo, Yukiko Fujita, Nobuko Arisue, Satoru Takeo, Kazuyuki Tanabe, Toshihiro Horii, Takafumi Tsuboi, Ken J Ishii and Cevayir Coban

    PLoS One, 6 (11), e28126, 2011.
16. Novel Strategies to Improve DNA Vaccine Immunogenicity.

    Cevayir Coban, Kouji Kobiyama, Taiki Aoshi, Fumihiko Takeshita, Toshihiro Horii, Shizuo Akira and Ken J Ishii

    Curr Gene Ther, 11 (6), 479-484, 2011.

Link

http://www.biken.osaka-u.ac.jp/