Department of Immunoregulation

Subjects:

1. Biochemistry and molecular biology of biosynthesis pathway of GPI-anchored proteins.
2. Molecular pathogenesis of a GPI-anchor deficiencies, paroxysmal nocturnal hemoglobinuria and inherited GPI deficiency.
3. Roles of GPI in microorganisms.

Published Papers

1. Impaired FcεRI stability, signaling and effector functions in murine mast cells lacking glycosylphosphatidylinositol-anchored proteins.

   Wouter L W Hazenbos, Ping Wu, Jeffrey Eastham-Anderson, Taroh Kinoshita and Eric J Brown

   Blood, 118 (16), 4377-4383, 2011.
2. Sorting of GPI-anchored proteins into ER exit sites by p24 proteins is dependent on remodeled GPI.

   Morihisa Fujita, Reika Watanabe, Nina Jaensch, Maria Romanova-Michaelides, Tadashi Satoh, Masaki Kato, Howard Riezman, Yoshiki Yamaguchi, Yusuke Maeda and Taroh Kinoshita

   J Cell Biol, 194 (1), 61-75, 2011.
3. Structural remodeling, trafficking and functions of glycosylphosphatidylinositol-anchored proteins.

   Yusuke Maeda and Taroh Kinoshita

   Prog Lipid Res, 50 (4), 411-424, 2011.
4. Inositol lipid metabolism in mycobacteria: biosynthesis and regulatory mechanisms.

   Yasu S Morita, Takeshi Fukuda, Chubert B C Sena, Yoshiki Yamaryo-Botte, Malcolm J McConville and Taroh Kinoshita

   Biochim Biophys Acta, 1810 (6), 630-641, 2011.
5. Safety and efficacy of the terminal complement inhibitor eculizumab in Japanese patients with paroxysmal nocturnal hemoglobinuria: the AEGIS clinical trial.

   Yuzuru Kanakura, Kazuma Ohyashiki, Tsutomu Shichishima, Shinichiro Okamoto, Kiyoshi Ando, Haruhiko Ninomiya, Tatsuya Kawaguchi, Shinji Nakao, Hideki Nakakuma, Jun-ichi Nishimura, Taroh Kinoshita, Camille L Bedrosian, Marye Ellen Valentine, Gus Khursigara, Keiya Ozawa and Mitsuhiro Omine

   Int J Hematol, 93 (1), 36-46, 2011.

Link

http://www.biken.osaka-u.ac.jp/