Department of Host Defense

Subjects:

1. Physiological roles of Toll-like receptor family and signaling pathways via TLRs.
2. Pathogen recognition mechanisms by innate immune system.

Published Papers

1. Innate and adaptive immune responses to viral infection and vaccination.

   Taiki Aoshi, Shohei Koyama, Kouji Kobiyama, Shizuo Akira and Ken J Ishii

   Curr Opin Virol, 1 (4), 226-232, 2011.
2. Stochastic binary modeling of cells in continuous time as an alternative to biochemical reaction equations.

   Shunsuke Teraguchi, Yutaro Kumagai, Alexis Vandenbon, Shizuo Akira and Daron M Standley

   Phys Rev E Stat Nonlin Soft Matter Phys, 84 (6 Pt.1), 062903, 2011.
3. Cytosolic RIG-I-like helicases act as negative regulators of sterile inflammation in the CNS.

   Angela Dann, Hendrik Poeck, Andrew L Croxford, Stefanie Gaupp, Katrin Kierdorf, Markus Knust, Dietmar Pfeifer, Cornelius Maihoefer, Stefan Endres, Ulrich Kalinke, Sven G Meuth, Heinz Wiendl, Klaus-Peter Knobeloch, Shizuo Akira, Ari Waisman, Gunther Hartmann and Marco Prinz

   Nat Neurosci, 15 (1), 98-106, 2011.
4. Characterization of dsRNA-induced pancreatitis model reveals the regulatory role of IFN regulatory factor 2 (Irf2) in trypsinogen5 gene transcription.

   Hideki Hayashi, Tomoko Kohno, Kiyoshi Yasui, Hiroyuki Murota, Tohru Kimura, Gordon S Duncan, Tomoki Nakashima, Kazuo Yamamoto, Ichiro Katayama, Yuhua Ma, Koon Jiew Chua, Takashi Suematsu, Isao Shimokawa, Shizuo Akira, Yoshinao Kubo, Tak Wah Mak and Toshifumi Matsuyama

   Proc Natl Acad Sci U S A, 108 (46), 18766-18771, 2011.
5. The IκB kinase complex regulates the stability of cytokine-encoding mRNA induced by TLR-IL-1R by controlling degradation of regnase-1.

   Hidenori Iwasaki, Osamu Takeuchi, Shunsuke Teraguchi, Kazufumi Matsushita, Takuya Uehata, Kanako Kuniyoshi, Takashi Satoh, Tatsuya Saitoh, Mutsuyoshi Matsushita, Daron M Standley and Shizuo Akira

   Nat Immunol, 12 (12), 1167-1175, 2011.
6. Novel Strategies to Improve DNA Vaccine Immunogenicity.

   Cevayir Coban, Kouji Kobiyama, Taiki Aoshi, Fumihiko Takeshita, Toshihiro Horii, Shizuo Akira and Ken J Ishii

   Curr Gene Ther, 11 (6), 479-484, 2011.
7. The protective role of TLR6 in a mouse model of asthma is mediated by IL-23 and IL-17A.

   Ana Paula Moreira, Karen A Cavassani, Ugur B Ismailoglu, Rikki Hullinger, Michael P Dunleavy, Darryl A Knight, Steven L Kunkel, Satoshi Uematsu, Shizuo Akira and Cory M Hogaboam

   J Clin Invest, 121 (11), 4420-4432, 2011.
8. Epigenetic control of macrophage polarization.

   Osamu Takeuch and Shizuo Akira

   Eur J Immunol, 41 (9), 2490-2493, 2011.
9. The TRAF-associated protein TANK facilitates cross-talk within the IκB kinase family during Toll-like receptor signaling.

   Kristopher Clark, Osamu Takeuchi, Shizuo Akira and Philip Cohen

   Proc Natl Acad Sci U S A, 108 (41), 17093-17098, 2011.
10. Mind Bomb Proteins in the Antiviral Arsenal.

    Yutaro Kumagai and Shizuo Akira

    Immunity, 35 (3), 320-322, 2011.
11. Lipocalin 2 plays an immunomodulatory role and has detrimental effects after spinal cord injury.

    Khizr I Rathore, Jennifer L Berard, Adriana Redensek, Sabrina Chierzi, Ruben Lopez-Vales, Manuela Santos, Shizuo Akira and Samuel David

    J Neurosci, 31 (38), 13412-13419, 2011.
12. TLR2-Mediated Production of IL-27 and Chemokines by Respiratory Epithelial Cells Promotes Bleomycin-Induced Pulmonary Fibrosis in Mice.

    Hye Sung Kim, Heounjeong Go, Shizuo Akira and Doo Hyun Chung

    J Immunol, 187 (8), 4007-4017, 2011.
13. [Role of PRRS in vaccine].

    Yutaro Kumagai and Shizuo Akira

    Nihon Rinsho, 69 (9), 1541-1546, 2011.
14. Innate immunity and adjuvants.

    Shizuo Akira

    Philos Trans R Soc Lond B Biol Sci, 366 (1579), 2748-2755, 2011.
15. Recognition of nucleic acids by pattern-recognition receptors and its relevance in autoimmunity.

    Takumi Kawasaki, Taro Kawai and Shizuo Akira

    Immunol Rev, 243 (1), 61-73, 2011.
16. MyD88 plays an essential role in inducing B cells capable of differentiating into antibody secreting cells after vaccination.

    Sang-Moo Kang, Dae-Goon Yoo, Min-Chul Kim, Jae-Min Song, Min-Kyung Park, O Eunju, Fu-Shi Quan, Shizuo Akira and Richard W Compans

    J Virol, 85 (21), 11391-11400, 2011.
17. Regulation of innate immune signalling pathways by the tripartite motif (TRIM) family proteins.

    Taro Kawai and Shizuo Akira

    EMBO Mol Med, 3 (9), 513-527, 2011.
18. Effect of Toll-like receptor 2 and 4 of corneal fibroblasts on cytokine expression with co-cultured antigen presenting cells.

    Hyuk Jin Choi, Mee Kum Kim, Jung Hwa Ko, Hyun Ju Lee, Hyun Jeong Jeong, Won Ryang Wee, Seung-Yong Seong and Shizuo Akira

    Cytokine, 56 (2), 265-271, 2011.
19. Pathogenic role of B cells in the development of diffuse alveolar hemorrhage induced by pristane.

    Tolga T Barker, Pui Y Lee, Kindra M Kelly-Scumpia, Jason S Weinstein, Dina C Nacionales, Yutaro Kumagai, Shizuo Akira, Byron P Croker, Eric S Sobel, Westley H Reeves and Minoru Satoh

    Lab Invest, 91 (10), 1540-1550, 2011.
20. DNA released from dying host cells mediates aluminum adjuvant activity.

    Thomas Marichal, Keiichi Ohata, Denis Bedoret, Claire Mesnil, Catherine Sabatel, Kouji Kobiyama, Pierre Lekeux, Cevayir Coban, Shizuo Akira, Ken J Ishii, Fabrice Bureau and Christophe J Desmet

    Nat Med, 17 (8), 996-1002, 2011.
21. B cells enhance early innate immune responses during bacterial sepsis.

    Kindra M Kelly-Scumpia, Philip O Scumpia, Jason S Weinstein, Matthew J Delano, Alex G Cuenca, Dina C Nacionales, James L Wynn, Pui Y Lee, Yutaro Kumagai, Philip A Efron, Shizuo Akira, Clive Wasserfall, Mark A Atkinson and Lyle L Moldawer

    J Exp Med, 208 (8), 1673-1682, 2011.
22. Unc93B1 Restricts Systemic Lethal Inflammation by Orchestrating Toll-like Receptor 7 and 9 Trafficking.

    Ryutaro Fukui, Shin-Ichiroh Saitoh, Atsuo Kanno, Masahiro Onji, Takuma Shibata, Akihiko Ito, Morikazu Onji, Mitsuru Matsumoto, Shizuo Akira, Nobuaki Yoshida and Kensuke Miyake

    Immunity, 35 (1), 69-81, 2011.
23. Viral infection augments nod1/2 signaling to potentiate lethality associated with secondary bacterial infections.

    Yun-Gi Kim, Jong-Hwan Park, Thornik Reimer, Darren P Baker, Taro Kawai, Himanshu Kumar, Shizuo Akira, Christiane Wobus and Gabriel Núñez

    Cell Host Microbe, 9 (6), 496-507, 2011.
24. Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity.

    Taro Kawai and Shizuo Akira

    Immunity, 34 (5), 637-650, 2011.
25. A New Subset of CD103+CD8α+ Dendritic Cells in the Small Intestine Expresses TLR3, TLR7, and TLR9 and Induces Th1 Response and CTL Activity.

    Kosuke Fujimoto, Thangaraj Karuppuchamy, Naoki Takemura, Masaki Shimohigoshi, Tomohisa Machida, Yasunari Haseda, Taiki Aoshi, Ken J Ishii, Shizuo Akira and Satoshi Uematsu

    J Immunol, 186 (11), 6287-6295, 2011.
26. The LC3 recruitment mechanism is separate from Atg9L1-dependent membrane formation in the autophagic response against Salmonella.

    Shun Kageyama, Hiroko Omori, Tatsuya Saitoh, Takefumi Sone, Jun-Lin Guan, Shizuo Akira, Fumio Imamoto, Takeshi Noda and Tamotsu Yoshimori

    Mol Biol Cell, 22 (13), 2290-2300, 2011.
27. Silica Crystals and Aluminum Salts Regulate the Production of Prostaglandin in Macrophages via NALP3 Inflammasome-Independent Mechanisms.

    Etsushi Kuroda, Ken J Ishii, Satoshi Uematsu, Keiichi Ohata, Cevayir Coban, Shizuo Akira, Kosuke Aritake, Yoshihiro Urade and Yasuo Morimoto

    Immunity, 34 (4), 514-526, 2011.
28. Regulation of Lipopolysaccharide-Induced Translation of Tumor Necrosis Factor-Alpha by the Toll-Like Receptor 4 Adaptor Protein TRAM.

    Lijian Wang, Estela Trebicka, Ying Fu, Lisa Waggoner, Shizuo Akira, Katherine A Fitzgerald, Jonathan C Kagan and Bobby J Cherayil

    J Innate Immun, 3 (5), 437-446, 2011.
29. Plasmacytoid Dendritic Cells Promote Host Defense against Acute Pneumovirus Infection via the TLR7-MyD88-Dependent Signaling Pathway.

    Sophia Davidson, Gerard Kaiko, Zhixuan Loh, Amit Lalwani, Vivian Zhang, Kirsten Spann, Shen Yun Foo, Nicole Hansbro, Satoshi Uematsu, Shizuo Akira, Klaus I Matthaei, Helene F Rosenberg, Paul S Foster and Simon Phipps

    J Immunol, 186 (10), 5938-5948, 2011.
30. Stat3 and MMP7 contribute to pancreatic ductal adenocarcinoma initiation and progression.

    Akihisa Fukuda, Sam C Wang, John P Morris, Alexandra E Folias, Angela Liou, Grace E Kim, Shizuo Akira, Kenneth M Boucher, Matthew A Firpo, Sean J Mulvihill and Matthias Hebrok

    Cancer Cell, 19 (4), 441-455, 2011.
31. Stat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer.

    Marina Lesina, Magdalena U Kurkowski, Katharina Ludes, Stefan Rose-John, Matthias Treiber, Günter Klöppel, Akihiko Yoshimura, Wolfgang Reindl, Bence Sipos, Shizuo Akira, Roland M Schmid and Hana Algül

    Cancer Cell, 19 (4), 456-469, 2011.
32. Adiponectin Enhances Insulin Sensitivity by Increasing Hepatic IRS-2 Expression via a Macrophage-Derived IL-6-Dependent Pathway.

    Motoharu Awazawa, Kohjiro Ueki, Kazunori Inabe, Toshimasa Yamauchi, Naoto Kubota, Kazuma Kaneko, Masatoshi Kobayashi, Aya Iwane, Takayoshi Sasako, Yukiko Okazaki, Mitsuru Ohsugi, Iseki Takamoto, Satoshi Yamashita, Hiroshi Asahara, Shizuo Akira, Masato Kasuga and Takashi Kadowaki

    Cell Metab, 13 (4), 401-412, 2011.
33. Zipper-interacting protein kinase modulates canonical Wnt/beta-catenin signaling through interacting with Nemo-like kinase and T-cell factor 4.

    Sumihito Togi, Osamu Ikeda, Shinya Kamitani, Misa Nakasuji, Yuichi Sekine, Ryuta Muromoto, Asuka Nanbo, Kenji Oritani, Taro Kawai, Shizuo Akira and Tadashi Matsuda

    J Biol Chem, 286 (21), 19170-19177, 2011.
34. TLR5-Deficient Mice Lack Basal Inflammatory and Metabolic Defects but Exhibit Impaired CD4 T Cell Responses to a Flagellated Pathogen.

    Shirdi E Letran, Seung-Joo Lee, Shaikh M Atif, Adriana Flores-Langarica, Satoshi Uematsu, Shizuo Akira, Adam F Cunningham and Stephen J McSorley

    J Immunol, 186 (9), 5406-5412, 2011.
35. Antiviral Protein Viperin Promotes Toll-like Receptor 7- and Toll-like Receptor 9-Mediated Type I Interferon Production in Plasmacytoid Dendritic Cells.

    Tatsuya Saitoh, Takashi Satoh, Naoki Yamamoto, Satoshi Uematsu, Osamu Takeuchi, Taro Kawai and Shizuo Akira

    Immunity, 34 (3), 352-363, 2011.
36. TNF-α from inflammatory dendritic cells (DCs) regulates lung IL-17A/IL-5 levels and neutrophilia versus eosinophilia during persistent fungal infection.

    Mingjian Fei, Shikha Bhatia, Timothy B Oriss, Manohar Yarlagadda, Anupriya Khare, Shizuo Akira, Shinobu Saijo, Yoichiro Iwakura, Beth A Fallert Junecko, Todd A Reinhart, Oded Foreman, Prabir Ray, Jay Kolls and Anuradha Ray

    Proc Natl Acad Sci U S A, 108 (13), 5360-5365, 2011.
37. Impaired Basophil Induction Leads to an Age-Dependent Innate Defect in Type 2 Immunity during Helminth Infection in Mice.

    Hendrik J Nel, Emily Hams, Sean P Saunders, Niamh E Mangan, Philip Smith, Ann Atzberger, Richard A Flavell, Shizuo Akira, Andrew N McKenzie and Padraic G Fallon

    J Immunol, 186 (8), 4631-4639, 2011.
38. Type I Interferon Signaling Regulates Ly6C Monocytes and Neutrophils during Acute Viral Pneumonia in Mice.

    Sang-Uk Seo, Hyung-Joon Kwon, Hyun-Jeong Ko, Young-Ho Byun, Baik Lin Seong, Satoshi Uematsu, Shizuo Akira and Mi-Na Kweon

    PLoS Pathog, 7 (2), e1001304, 2011.
39. Enhanced efficacy of therapeutic cancer vaccines produced by co-treatment with Mycobacterium tuberculosis heparin-binding hemagglutinin, a novel TLR4 agonist.

    In Duk Jung, Soo Kyung Jeong, Chang-Min Lee, Kyung Tae Noh, Deok Rim Heo, Yong Kyoo Shin, Cheol-Heui Yun, Won-Jung Koh, Shizuo Akira, Jake Whang, Hwa-Jung Kim, Won Sun Park, Sung Jae Shin and Yeong-Min Park

    Cancer Res, 71 (8), 2858-2870, 2011.
40. Microsomal prostaglandin E synthase-1 enhances bone cancer growth and bone cancer-related pain behaviors in mice.

    Masako Isono, Tatsunori Suzuki, Kanako Hosono, Izumi Hayashi, Hiroyuki Sakagami, Satoshi Uematsu, Shizuo Akira, Yves A Declerck, Hirotugu Okamoto and Masataka Majima

    Life Sci, 88 (15-16), 693-700, 2011.
41. Conventional dendritic cells mount a type I IFN response against Candida spp. requiring novel phagosomal TLR7-mediated IFN-beta signaling.

    Christelle Bourgeois, Olivia Majer, Ingrid E Frohner, Iwona Lesiak-Markowicz, Kwang-Soo Hildering, Walter Glaser, Silvia Stockinger, Thomas Decker, Shizuo Akira, Mathias Müller and Karl Kuchler

    J Immunol, 186 (5), 3104-3112, 2011.
42. Mycobacterial hypersensitivity pneumonitis requires TLR9-MyD88 in lung CD11b+CD11c+ cells.

    H Daito, T Kikuchi, T Sakakibara, K Gomi, T Damayanti, J Zaini, N Tode, M Kanehira, S Koyama, S Fujimura, M Ebina, K J Ishii, S Akira, T Takai, A Watanabe and T Nukiwa

    Eur Respir J, 38 (3), 688-701, 2011.
43. Homeostatic defects in interleukin 18-deficient mice contribute to protection against the lethal effects of endotoxin.

    Daniel M Andrews, Melvyn T Chow, Yuting Ma, Claire L Cotterell, Sally V Watt, Desiree A Anthony, Shizuo Akira, Yoichiro Iwakura, Joseph A Trapani, Laurence Zitvogel and Mark J Smyth

    Immunol Cell Biol, 89 (6), 739-746, 2011.
44. Antigen-Specific T-Cell Responses to a Recombinant Fowlpox Virus Are Dependent on MyD88 and Interleukin-18 and Independent of Toll-Like Receptor 7 (TLR7)- and TLR9-Mediated Innate Immune Recognition.

    Erin L Lousberg, Kerrilyn R Diener, Cara K Fraser, Simon Phipps, Paul S Foster, Weisan Chen, Satoshi Uematsu, Shizuo Akira, Sarah A Robertson, Michael P Brown and John D Hayball

    J Virol, 85 (7), 3385-3396, 2011.
45. The inducible prostaglandin E synthase mPGES-1 regulates growth of endometrial tissues and angiogenesis in a mouse implantation model.

    Akiko Numao, Kanako Hosono, Tatsunori Suzuki, Izumi Hayashi, Satoshi Uematsu, Shizuo Akira, Yukiko Ogino, Hirohito Kawauchi, Nobuya Unno and Masataka Majima

    Biomed Pharmacother, 65 (1), 77-84, 2011.
46. Rapid host defense against Aspergillus fumigatus involves alveolar macrophages with a predominance of alternatively activated phenotype.

    Shikha Bhatia, Mingjian Fei, Manohar Yarlagadda, Zengbiao Qi, Shizuo Akira, Shinobu Saijo, Yoichiro Iwakura, Nico van Rooijen, Gregory A Gibson, Claudette M St Croix, Anuradha Ray and Prabir Ray

    PLoS One, 6 (1), e15943, 2011.
47. Pathogen recognition by the innate immune system.

    Himanshu Kumar, Taro Kawai and Shizuo Akira

    Int Rev Immunol, 30 (1), 16-34, 2011.
48. Endothelial microsomal prostaglandin E synthase-1 facilitates neurotoxicity by elevating astrocytic Ca(2+) levels.

    Takako Takemiya, Kiyoshi Matsumura, Hiroko Sugiura, Shin Yasuda, Satoshi Uematsu, Shizuo Akira and Kanato Yamagata

    Neurochem Int, 58 (4), 489-496, 2011.
49. IL-1α Modulates Neutrophil Recruitment in Chronic Inflammation Induced by Hydrocarbon Oil.

    Pui Y Lee, Yutaro Kumagai, Yuan Xu, Yi Li, Tolga Barker, Chao Liu, Eric S Sobel, Osamu Takeuchi, Shizuo Akira, Minoru Satoh and Westley H Reeves

    J Immunol, 186 (3), 1747-1754, 2011.
50. TLR5 functions as an endocytic receptor to enhance flagellin-specific adaptive immunity.

    Shirdi E Letran, Seung-Joo Lee, Shaikh M Atif, Satoshi Uematsu, Shizuo Akira and Stephen J McSorley

    Eur J Immunol, 41 (1), 29-38, 2011.
51. Influenza infection in suckling mice expands an NKT cell subset that protects against airway hyperreactivity.

    Ya-Jen Chang, Hye Young Kim, Lee A Albacker, Hyun Hee Lee, Nicole Baumgarth, Shizuo Akira, Paul B Savage, Shin Endo, Takashi Yamamura, Janneke Maaskant, Naoki Kitano, Abel Singh, Apoorva Bhatt, Gurdyal S Besra, Peter van den Elzen, Ben Appelmelk, Richard W Franck, Guangwu Chen, Rosemarie H Dekruyff, Michio Shimamura, Petr Illarionov and Dale T Umetsu

    J Clin Invest, 121 (1), 57-69, 2011.
52. NLRC5 Deficiency Does Not Influence Cytokine Induction by Virus and Bacteria Infections.

    Himanshu Kumar, Surya Pandey, Jian Zou, Yutaro Kumagai, Ken Takahashi, Shizuo Akira and Taro Kawai

    J Immunol, 188 (2), 994-1000, 2011.
53. TLR5 functions as an endocytic receptor to enhance flagellin-specific adaptive immunity.

    Shirdi E Letran, Seung-Joo Lee, Shaikh M Atif, Satoshi Uematsu, Shizuo Akira and Stephen J McSorley

    Eur J Immunol, 41 (1), 29-38, 2011.
54. Contribution of IPS-1 to polyI:C-induced cytokine production in conjunctival epithelial cells.

    Mayumi Ueta, Taro Kawai, Norihiko Yokoi, Shizuo Akira and Shigeru Kinoshita

    Biochem Biophys Res Commun, 404 (1), 419-423, 2011.
55. Akt Contributes to Activation of the TRIF-Dependent Signaling Pathways of TLRs by Interacting with TANK-Binding Kinase 1.

    Sun Myung Joung, Zee-Yong Park, Shilpa Rani, Osamu Takeuchi, Shizuo Akira and Joo Young Lee

    J Immunol, 186 (1), 499-507, 2011.
56. MyD88-Dependent Signaling Protects against Anthrax Lethal Toxin-Induced Impairment of Intestinal Barrier Function.

    Shu Okugawa, Mahtab Moayeri, Michael A Eckhaus, Devorah Crown, Sharmina Miller-Randolph, Shihui Liu, Shizuo Akira and Stephen H Leppla

    Infect Immun, 79 (1), 118-124, 2011.
57. Essential Role of B7-H1 in Double-stranded RNA-induced Augmentation of an Asthma Phenotype in Mice.

    Koichiro Matsumoto, Keiko Kan-O, Miyuki Eguchi-Tsuda, Satoru Fukuyama, Yukari Asai, Takafumi Matsumoto, Atsushi Moriwaki, Yuko Matsunaga, Hiroko Tsutsui, Taro Kawai, Osamu Takeuchi, Shizuo Akira, Hideo Yagita, Miyuki Azuma, Yoichi Nakanishi and Hiromasa Inoue

    Am J Respir Cell Mol Biol, 45 (1), 31-39, 2011.
58. Crohn disease: A current perspective on genetics, autophagy and immunity.

    Thaddeus S Stappenbeck, John D Rioux, Atsushi Mizoguchi, Tatsuya Saitoh, Alan Huett, Arlette Darfeuille-Michaud, Tom Wileman, Noboru Mizushima, Simon Carding, Shizuo Akira, Miles Parkes and Ramnik J Xavier

    Autophagy, 7 (4), 355-374, 2011.
59. Airway Epithelial Indoleamine 2,3-Dioxygenase Inhibits CD4+ T Cells During Aspergillus fumigatus Antigen Exposure.

    Sara A Paveglio, Jenna Allard, Samantha R Foster Hodgkins, Jennifer Ather, Mieke Bevelander, Jana Mayette Campbell, Laurie A Whittaker Leclair, Sean M McCarthy, Albert van der Vliet, Benjamin T Suratt, Jonathan E Boyson, Satoshi Uematsu, Shizuo Akira and Matthew E Poynter

    Am J Respir Cell Mol Biol, 44 (1), 11-23, 2011.

Link

http://www.biken.osaka-u.ac.jp/