Department of Signal Transduction

Subjects:

1. Elucidation of the tube-forming mechanism by investigating the polarity of ECs.
2. Analysis of the functional role(s) of Tie2 and down stream of Tie2 in the maturation of blood vessels.
3. Analysis of hematopoietic cells in angiogenesis.
4. Analysis of specification between artery and vein.
5. Analysis of stem cell system in blood vessels.
6. Functional analysis of GINS complex and galectin-3 in stem cells.

Published Papers

1. PSF1, a DNA replication factor expressed widely in stem and progenitor cells, drives tumorigenic and metastatic properties.

   Yumi Nagahama, Masaya Ueno, Satoru Miyamoto, Eiichi Morii, Takashi Minami, Naoki Mochizuki, Hideyuki Saya and Nobuyuki Takakura

   Cancer Res, 70 (3), 1215-1224, 2010.
2. Apelin induces enlarged and non-leaky blood vessels for functional recovery from ischemia.

   Hiroyasu Kidoya, Hisamichi Naito and Nobuyuki Takakura

   Blood, 115 (15), 3166-3174, 2010.
3. Sphingosine 1-Phosphate Regulates Vascular Contraction via S1P3 Receptor: Investigation Based on a New S1P3 Receptor Antagonist.

   Akira Murakami, Hiroshi Takasugi, Shinya Ohnuma, Yuuki Koide, Atsuko Sakurai, Satoshi Takeda, Takeshi Hasegawa, Jun Sasamori, Takashi Konno, Kenji Hayashi, Yoshiaki Watanabe, Koji Mori, Yoshimichi Sato, Atsuo Takahashi, Naoki Mochizuki and Nobuyuki Takakura

   Mol Pharmacol, 77 (4), 704-713, 2010.
4. PSF3 marks malignant colon cancer and has a role in cancer cell proliferation.

   Yumi Nagahama, Masaya Ueno, Naotsugu Haraguchi, Masaki Mori and Nobuyuki Takakura

   Biochem Biophys Res Commun, 392 (2), 150-154, 2010.
5. A liver-derived secretory protein, selenoprotein P, causes insulin resistance.

   Hirofumi Misu, Toshinari Takamura, Hiroaki Takayama, Hiroto Hayashi, Naoto Matsuzawa-Nagata, Seiichiro Kurita, Kazuhide Ishikura, Hitoshi Ando, Yumie Takeshita, Tsuguhito Ota, Masaru Sakurai, Tatsuya Yamashita, Eishiro Mizukoshi, Taro Yamashita, Masao Honda, Ken-ichi Miyamoto, Tetsuya Kubota, Naoto Kubota, Takashi Kadowaki, Han-Jong Kim, In-kyu Lee, Yasuhiko Minokoshi, Yoshiro Saito, Kazuhiko Takahashi, Yoshihiro Yamada, Nobuyuki Takakura and Shuichi Kaneko

   Cell Metab, 12 (5), 483-495, 2010.
6. Up-regulation of PSF1 promotes the growth of breast cancer cells.

   Izumi Nakahara, Mamiko Miyamoto, Tatsuhiro Shibata, Sadako Akashi-Tanaka, Takayuki Kinoshita, Kaoru Mogushi, Kohtaro Oda, Masaya Ueno, Nobuyuki Takakura, Hiroshi Mizushima, Hiroshi Tanaka and Tsutomu Ohta

   Genes Cells, 15 (10), 1015-1024, 2010.
7. Identification and functional analysis of endothelial tip cell-enriched genes.

   Raquel del Toro, Claudia Prahst, Thomas Mathivet, Geraldine Siegfried, Joshua S Kaminker, Bruno Larrivee, Christiane Breant, Antonio Duarte, Nobuyuki Takakura, Akiyoshi Fukamizu, Josef Penninger and Anne Eichmann

   Blood, 116 (19), 4025-4033, 2010.

Link

http://www.biken.osaka-u.ac.jp/