Department of Molecular Protozoology

Subjects:

1. Development of a recombinant vaccine based on the malaria protein SERA.
2. Development of a novel vaccine adjuvant and elucidation of its mechanism of action.
3. Study on host-parasite interaction of malaria infection.
4. Study on phylogeny and evolution of SERA multigene family in the genus Plasmodium.

Published Papers

1. Limited polymorphism of the Plasmodium vivax merozoite surface protein 1 gene in isolates from Turkey.

   Fadile Yildiz Zeyrek, Shin-Ichiro Tachibana, Fehmi Yuksel, Nebiye Doni, Nirianne Palacpac, Nobuko Arisue, Toshihiro Horii, Cevayir Coban and Kazuyuki Tanabe

   Am J Trop Med Hyg, 83 (6), 1230-1237, 2010.
2. Rapid and highly sensitive detection of malaria-infected erythrocytes using a cell microarray chip.

   Shouki Yatsushiro, Shohei Yamamura, Yuka Yamaguchi, Yasuo Shinohara, Eiichi Tamiya, Toshihiro Horii, Yoshinobu Baba and Masatoshi Kataoka

   PLoS One, 5 (10), e13179, 2010.
3. Plasmodium falciparum accompanied the human expansion out of Africa.

   Kazuyuki Tanabe, Toshihiro Mita, Thibaut Jombart, Anders Eriksson, Shun Horibe, Nirianne Palacpac, Lisa Ranford-Cartwright, Hiromi Sawai, Naoko Sakihama, Hiroshi Ohmae, Masatoshi Nakamura, Marcelo U Ferreira, Ananias A Escalante, Franck Prugnolle, Anders Björkman, Anna Färnert, Akira Kaneko, Toshihiro Horii, Andrea Manica, Hirohisa Kishino and Francois Balloux

   Curr Biol, 20 (14), 1283-1289, 2010.
4. TLR9 and endogenous adjuvants of the whole blood-stage malaria vaccine.

   Cevayir Coban, Toshihiro Horii, Shizuo Akira and Ken J Ishii

   Expert Rev Vaccines, 9 (7), 775-784, 2010.
5. Evidences of protection against blood-stage infection of Plasmodium falciparum by the novel protein vaccine SE36.

   Toshihiro Horii, Hiroki Shirai, Li Jie, Ken J Ishii, Nirianne Q Palacpac, Takahiro Tougan, Mariko Hato, Nobuo Ohta, Albino Bobogare, Nana Arakaki, Yoshitsugu Matsumoto, Junko Namazue, Toyokazu Ishikawa, Shigeharu Ueda and Michiaki Takahashi

   Parasitol Int, 59 (3), 380-386, 2010.
6. The malarial metabolite hemozoin and its potential use as a vaccine adjuvant.

   Cevayir Coban, Masanori Yagi, Keiichi Ohata, Yoshikatsu Igari, Toshihiro Tsukui, Toshihiro Horii, Ken J Ishii and Shizuo Akira

   Allergol Int, 59 (2), 115-124, 2010.
7. Lineage-specific positive selection at the merozoite surface protein 1 (msp1) locus of Plasmodium vivax and related simian malaria parasites.

   Hiromi Sawai, Hiroto Otani, Nobuko Arisue, Nirianne Palacpac, Leonardo de Oliveira Martins, Sisira Pathirana, Shiroma Handunnetti, Satoru Kawai, Hirohisa Kishino, Toshihiro Horii and Kazuyuki Tanabe

   BMC Evol Biol, 10, 52, 2010.
8. New anti-malarial phenylpropanoid conjugated iridoids from Morinda morindoides.

   Satoru Tamura, Bruno Kilunga Kubata, Syamsurizal, Sawako Itagaki, Toshihiro Horii, Muzele Kalulu Taba and Nobutoshi Murakami

   Bioorg Med Chem Lett, 20 (5), 1520-1523, 2010.
9. Immunogenicity of whole-parasite vaccines against Plasmodium falciparum involves malarial hemozoin and host TLR9.

   Cevayir Coban, Yoshikatsu Igari, Masanori Yagi, Thornik Reimer, Shohei Koyama, Taiki Aoshi, Keiichi Ohata, Toshihiro Tsukui, Fumihiko Takeshita, Kazuo Sakurai, Takahisa Ikegami, Atsushi Nakagawa, Toshihiro Horii, Gabriel Nuñez, Ken J Ishii and Shizuo Akira

   Cell Host Microbe, 7 (1), 50-61, 2010.
10. Divergence of the mitochondrial genome structure in the apicomplexan parasites, Babesia and Theileria.

    Kenji Hikosaka, Yoh-Ichi Watanabe, Naotoshi Tsuji, Kiyoshi Kita, Hiroe Kishine, Nobuko Arisue, Nirianne Marie Q Palacpac, Shin-Ichiro Kawazu, Hiromi Sawai, Toshihiro Horii, Ikuo Igarashi and Kazuyuki Tanabe

    Mol Biol Evol, 27 (5), 1107-1116, 2010.
11. Experimental Cerebral Malaria Progresses Independently of the Nlrp3 Inflammasome.

    Thornik Reimer, Michael H Shaw, Luigi Franchi, Cevayir Coban, Ken J Ishii, Shizuo Akira, Toshihiro Horii, Ana Rodriguez and Gabriel Núñez

    Eur J Immunol, 40 (3), 764-769, 2010.
12. Phylogeny of Asian primate malaria parasites inferred from apicoplast genome-encoded genes with special emphasis on the positions of Plasmodium vivax and P. fragile.

    Hideya Mitsui, Nobuko Arisue, Naoko Sakihama, Yuji Inagaki, Toshihiro Horii, Masami Hasegawa, Kazuyuki Tanabe and Tetsuo Hashimoto

    Gene, 450 (1-2), 32-38, 2010.

Link

http://www.biken.osaka-u.ac.jp/