Department of Molecular Immunology

Subjects:

1. Molecular mechanisms involved in regulation of immune responses.
2. Mechanism of development of autoimmune diseases.
3. Molecular mechanism by which Epstein-Barr virus (EBV) causes B cell growth transformation and the modification of the differentiation.

Published Papers

1. Diminished contact-dependent reinforcement of Syk activation underlies impaired thrombus growth in mice lacking Semaphorin 4D.

   Kenneth M Wannemacher, Li Zhu, Hong Jiang, Karen P Fong, Timothy J Stalker, Dooyoung Lee, Anh N Tran, Keith B Neeves, Sean Maloney, Atsushi Kumanogoh, Hitoshi Kikutani, Daniel A Hammer, Scott L Diamond and Lawrence F Brass

   Blood, 116 (25), 5707-5715, 2010.
2. Integral roles of a guanine nucleotide exchange factor, FARP2, in osteoclast podosome rearrangements.

   Noriko Takegahara, Sujin Kang, Satoshi Nojima, Hyota Takamatsu, Tatsusada Okuno, Hitoshi Kikutani, Toshihiko Toyofuku and Atsushi Kumanogoh

   FASEB J, 24 (12), 4782-4792, 2010.
3. Semaphorins and their receptors: novel features of neural guidance molecules.

   Atsushi Kumanogoh and Hitoshi Kikutani

   Proc Jpn Acad Ser B Phys Biol Sci, 86 (6), 611-620, 2010.
4. Deletion of Sema4D gene reduces intimal neovascularization and plaque growth in apolipoprotein E-deficient mice.

   Kazunori Yukawa, Tetsuji Tanaka, Masanori Kishino, Kenji Yoshida, Noriko Takeuchi, Takuji Ito, Hyota Takamatsu, Hitoshi Kikutani and Atsushi Kumanogoh

   Int J Mol Med, 26 (1), 39-44, 2010.
5. Semaphorins guide the entry of dendritic cells into the lymphatics by activating myosin II.

   Hyota Takamatsu, Noriko Takegahara, Yukinobu Nakagawa, Michio Tomura, Masahiko Taniguchi, Roland H Friedel, Helen Rayburn, Marc Tessier-Lavigne, Yutaka Yoshida, Tatsusada Okuno, Masayuki Mizui, Sujin Kang, Satoshi Nojima, Tohru Tsujimura, Yuji Nakatsuji, Ichiro Katayama, Toshihiko Toyofuku, Hitoshi Kikutani and Atsushi Kumanogoh

   Nat Immunol, 11 (7), 594-600, 2010.
6. Critical role of IkappaB Kinase alpha in TLR7/9-induced type I IFN production by conventional dendritic cells.

   Katsuaki Hoshino, Izumi Sasaki, Takahiro Sugiyama, Takahiro Yano, Chihiro Yamazaki, Teruhito Yasui, Hitoshi Kikutani and Tsuneyasu Kaisho

   J Immunol, 184 (7), 3341-3345, 2010.
7. Sema4A induces cell morphological changes through B-type plexin-mediated signaling.

   Kazunori Yukawa, Tetsuji Tanaka, Kenji Yoshida, Noriko Takeuchi, Takuji Ito, Hyota Takamatsu, Hitoshi Kikutani and Atsushi Kumanogoh

   Int J Mol Med, 25 (2), 225-230, 2010.
8. Roles of Sema4D-Plexin-B1 Interactions in the Central Nervous System for Pathogenesis of Experimental Autoimmune Encephalomyelitis.

   Tatsusada Okuno, Yuji Nakatsuji, Masayuki Moriya, Hyota Takamatsu, Satoshi Nojima, Noriko Takegahara, Toshihiko Toyofuku, Yukinobu Nakagawa, Sujin Kang, Roland H Friedel, Saburo Sakoda, Hitoshi Kikutani and Atsushi Kumanogoh

   J Immunol, 184 (3), 1499-1508, 2010.

Link

http://www.biken.osaka-u.ac.jp/