Department of Molecular Genetics

Subjects:

1. Molecular mechanisms regulating the cell cycle in mammalian cells.
2. Molecular mechanisms controlling the meiosis in fission yeast.
3. Molecular mechanisms modulating the metastasis of malignant cells.
4. Application of a new technique (stepwise subtraction) to RNA diagnosis.

Published Papers

1. The Mek1 phosphorylation cascade plays a role in meiotic recombination of Schizosaccharomyces pombe.

   Takahiro Tougan, Takashi Kasama, Ayami Ohtaka, Daisuke Okuzaki, Takamune T Saito, Paul Russell and Hiroshi Nojima

   Cell Cycle, 9 (23), 4688-4702, 2010.
2. GenopalTM: A Novel Hollow Fibre Array for Focused Microarray Analysis.

   Daisuke Okuzaki, Tatsunobu Fukushima, Takahiro Tougan, Tomonori Ishii, Shigeto Kobayashi, Kazuyuki Yoshizaki, Takashi Akita and Hiroshi Nojima

   DNA Res, 17 (6), 369-379, 2010.
3. The Lats2 tumor suppressor augments p53-mediated apoptosis by promoting the nuclear proapoptotic function of ASPP1.

   Yael Aylon, Yaara Ofir-Rosenfeld, Norikazu Yabuta, Eleonora Lapi, Hiroshi Nojima, Xin Lu and Moshe Oren

   Genes Dev, 24 (21), 2420-2429, 2010.
4. Nucleoredoxin sustains Wnt/β-catenin signaling by retaining a pool of inactive dishevelled protein.

   Yosuke Funato, Takeshi Terabayashi, Reiko Sakamoto, Daisuke Okuzaki, Hirotake Ichise, Hiroshi Nojima, Nobuaki Yoshida and Hiroaki Miki

   Curr Biol, 20 (21), 1945-1952, 2010.
5. Spo5 phosphorylation is essential for its own timely degradation and for successful meiosis in Schizosaccharomyces pombe.

   Daisuke Okuzaki, Takashi Kasama, Aiko Hirata, Ayami Ohtaka, Reiko Kakegawa and Hiroshi Nojima

   Cell Cycle, 9 (18), 3751-3760, 2010.
6. Mug28, a meiosis-specific protein of Schizosaccharomyces pombe, regulates spore wall formation.

   Akira Shigehisa, Daisuke Okuzaki, Takashi Kasama, Hideki Tohda, Aiko Hirata and Hiroshi Nojima

   Mol Biol Cell, 21 (12), 1955-1967, 2010.
7. Microarray analysis of tonsils in immunoglobulin A nephropathy patients.

   Kenichiro Iio, Yasuyuki Nagasawa, Hirotsugu Iwatani, Ryohei Yamamoto, Arata Horii, Daisuke Okuzaki, Yoshiyuki Furumatsu, Hidenori Inohara, Hiroshi Nojima, Enyu Imai, Yoshitaka Isaka and Hiromi Rakugi

   Biochem Biophys Res Commun, 393 (4), 565-570, 2010.

Link

http://www.biken.osaka-u.ac.jp/