Laboratory of Malariology

Subjects:

1. Evolutionary history of malaria parasites.
2. The evolution of antigen polymorphism in malaria parasites.
3. Co-evolution of malaria parasites and hosts.
4. The evolution of the mitochondrial genome of Apicomplexa.
5. Comparative genomics of Plasmodium vivax and related simian parasites.
6. Simulation of malaria drug resistance using mutator parasites.

Published Papers

1. Limited polymorphism of the Plasmodium vivax merozoite surface protein 1 gene in isolates from Turkey.

   Fadile Yildiz Zeyrek, Shin-Ichiro Tachibana, Fehmi Yuksel, Nebiye Doni, Nirianne Palacpac, Nobuko Arisue, Toshihiro Horii, Cevayir Coban and Kazuyuki Tanabe

   Am J Trop Med Hyg, 83 (6), 1230-1237, 2010.
2. Plasmodium falciparum accompanied the human expansion out of Africa.

   Kazuyuki Tanabe, Toshihiro Mita, Thibaut Jombart, Anders Eriksson, Shun Horibe, Nirianne Palacpac, Lisa Ranford-Cartwright, Hiromi Sawai, Naoko Sakihama, Hiroshi Ohmae, Masatoshi Nakamura, Marcelo U Ferreira, Ananias A Escalante, Franck Prugnolle, Anders Björkman, Anna Färnert, Akira Kaneko, Toshihiro Horii, Andrea Manica, Hirohisa Kishino and Francois Balloux

   Curr Biol, 20 (14), 1283-1289, 2010.
3. Geographical origin of Plasmodium vivax in the Republic of Korea: haplotype network analysis based on the parasite's mitochondrial genome.

   Moritoshi Iwagami, Seung-Young Hwang, Megumi Fukumoto, Toshiyuki Hayakawa, Kazuyuki Tanabe, So-Hee Kim, Weon-Gyu Kho and Shigeyuki Kano

   Malar J, 9, 184, 2010.
4. Evaluation of a loop-mediated isothermal amplification method as a tool for diagnosis of infection by the zoonotic simian malaria parasite Plasmodium knowlesi.

   Hiroshi Iseki, Satoru Kawai, Nobuyuki Takahashi, Makoto Hirai, Kazuyuki Tanabe, Naoaki Yokoyama and Ikuo Igarashi

   J Clin Microbiol, 48 (7), 2509-2514, 2010.
5. Divergence of the mitochondrial genome structure in the apicomplexan parasites, Babesia and Theileria.

   Kenji Hikosaka, Yoh-Ichi Watanabe, Naotoshi Tsuji, Kiyoshi Kita, Hiroe Kishine, Nobuko Arisue, Nirianne Marie Q Palacpac, Shin-Ichiro Kawazu, Hiromi Sawai, Toshihiro Horii, Ikuo Igarashi and Kazuyuki Tanabe

   Mol Biol Evol, 27 (5), 1107-1116, 2010.
6. Phylogeny of Asian primate malaria parasites inferred from apicoplast genome-encoded genes with special emphasis on the positions of Plasmodium vivax and P. fragile.

   Hideya Mitsui, Nobuko Arisue, Naoko Sakihama, Yuji Inagaki, Toshihiro Horii, Masami Hasegawa, Kazuyuki Tanabe and Tetsuo Hashimoto

   Gene, 450 (1-2), 32-38, 2010.

Link

http://www.biken.osaka-u.ac.jp/