Department of Host Defense

Subjects:

1. Pathogen recognition mechanisms by innate immune system.
2. Regulatory mechanisms of inflammatory responses.

Published Papers

1. Hepatitis C virus core protein abrogates the DDX3 function that enhances IPS-1-mediated IFN-beta induction.

   Hiroyuki Oshiumi, Masanori Ikeda, Misako Matsumoto, Ayako Watanabe, Osamu Takeuchi, Shizuo Akira, Nobuyuki Kato, Kunitada Shimotohno and Tsukasa Seya

   PLoS One, 5 (12), e14258, 2010.
2. Trib1 is a lipid- and myocardial infarction-associated gene that regulates hepatic lipogenesis and VLDL production in mice.

   Ralph Burkhardt, Sue-Anne Toh, William R Lagor, Andrew Birkeland, Michael Levin, Xiaoyu Li, Megan Robblee, Victor D Fedorov, Masahiro Yamamoto, Takashi Satoh, Shizuo Akira, Sekar Kathiresan, Jan L Breslow and Daniel J Rader

   J Clin Invest, 120 (12), 4410-4414, 2010.
3. The ubiquitin ligase TRIM56 regulates innate immune responses to intracellular double-stranded DNA.

   Tetsuo Tsuchida, Jian Zou, Tatsuya Saitoh, Himanshu Kumar, Takayuki Abe, Yoshiharu Matsuura, Taro Kawai and Shizuo Akira

   Immunity, 33 (5), 765-776, 2010.
4. MyD88 signaling is indispensable for primary influenza A virus infection but dispensable for secondary infection.

   Sang-Uk Seo, Hyung-Joon Kwon, Joo-Hye Song, Young-Ho Byun, Baik Lin Seong, Taro Kawai, Shizuo Akira and Mi-Na Kweon

   J Virol, 84 (24), 12713-12722, 2010.
5. The role of adrenomedullin in Lyme disease.

   Meghan L Marre, Courtney T Darcy, Janeth Yinh, Shizuo Akira, Satoshi Uematsu, Allen C Steere and Linden T Hu

   Infect Immun, 78 (12), 5307-5313, 2010.
6. IκBζ is essential for natural killer cell activation in response to IL-12 and IL-18.

   Tohru Miyake, Takashi Satoh, Hiroki Kato, Kazufumi Matsushita, Yutaro Kumagai, Alexis Vandenbon, Tohru Tani, Tatsushi Muta, Shizuo Akira and Osamu Takeuchi

   Proc Natl Acad Sci U S A, 107 (41), 17680-17685, 2010.
7. Immunological basis of M13 phage vaccine: Regulation under MyD88 and TLR9 signaling.

   Shuhei Hashiguchi, Yuya Yamaguchi, Osamu Takeuchi, Shizuo Akira and Kazuhisa Sugimura

   Biochem Biophys Res Commun, 402 (1), 19-22, 2010.
8. Induction of type I interferon by adenovirus-encoded small RNAs.

   Tomoko Yamaguchi, Kenji Kawabata, Emi Kouyama, Ken J Ishii, Kazufumi Katayama, Takayuki Suzuki, Shinnosuke Kurachi, Fuminori Sakurai, Shizuo Akira and Hiroyuki Mizuguchi

   Proc Natl Acad Sci U S A, 107 (40), 17286-17291, 2010.
9. Toll-Like Receptor 9 Enhances Nephritogenic Immunity and Glomerular Leukocyte Recruitment, Exacerbating Experimental Crescentic Glomerulonephritis.

   Shaun A Summers, Oliver M Steinmetz, Joshua D Ooi, Poh-Yi Gan, Kim M O'Sullivan, Kumar Visvanathan, Shizuo Akira, A Richard Kitching and Stephen R Holdsworth

   Am J Pathol, 177 (5), 2234-2244, 2010.
10. Role of MyD88 and Toll-Like Receptor (TLR) 2 and TLR4 in the Sensing of Parachlamydia acanthamoebae.

    Thierry Roger, Nicola Casson, Antony Croxatto, José Manuel Entenza, Marc Pusztaszeri, Shizuo Akira, Marlies Knaup Reymond, Didier Le Roy, Thierry Calandra and Gilbert Greub

    Infect Immun, 78 (12), 5195-5201, 2010.
11. Apolipoprotein CIII Induces Monocyte Chemoattractant Protein-1 and Interleukin 6 Expression Via Toll-Like Receptor 2 Pathway in Mouse Adipocytes.

    Yasuko Abe, Akio Kawakami, Mizuko Osaka, Satoshi Uematsu, Shizuo Akira, Kentaro Shimokado, Frank M Sacks and Masayuki Yoshida

    Arterioscler Thromb Vasc Biol, 30 (11), 2242-2248, 2010.
12. Myeloid differentiation factor 88 (MyD88)-deficiency increases risk of diabetes in mice.

    Toru Hosoi, Shota Yokoyama, Suguru Matsuo, Shizuo Akira and Koichiro Ozawa

    PLoS One, 5 (9), e12537, 2010.
13. Role of microsomal prostaglandin E synthase-1 in the facilitation of angiogenesis and the healing of gastric ulcers.

    Takako Ae, Takashi Ohno, Youichiro Hattori, Tatsunori Suzuki, Kanako Hosono, Tsutomu Minamino, Takehito Sato, Satoshi Uematsu, Shizuo Akira, Wasaburo Koizumi and Masataka Majima

    Am J Physiol Gastrointest Liver Physiol, 299 (5), G1139-G1146, 2010.
14. TLR9 and TLR4 are required for the development of autoimmunity and lupus nephritis in pristane nephropathy.

    S A Summers, A Hoi, O M Steinmetz, K M O'Sullivan, J D Ooi, D Odobasic, S Akira, A R Kitching and S R Holdsworth

    J Autoimmun, 35 (4), 291-298, 2010.
15. Toll-like receptor 4 (TLR4), but not TLR3 or TLR9, knock-out mice have neuroprotective effects against focal cerebral ischemia.

    K Hyakkoku, J Hamanaka, K Tsuruma, M Shimazawa, H Tanaka, S Uematsu, S Akira, N Inagaki, H Nagai and H Hara

    Neuroscience, 17 (1), 258-267, 2010.
16. The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection.

    Takashi Satoh, Osamu Takeuchi, Alexis Vandenbon, Koubun Yasuda, Yoshiaki Tanaka, Yutaro Kumagai, Tohru Miyake, Kazufumi Matsushita, Toshihiko Okazaki, Tatsuya Saitoh, Kiri Honma, Toshifumi Matsuyama, Katsuyuki Yui, Tohru Tsujimura, Daron M Standley, Kenji Nakanishi, Kenta Nakai and Shizuo Akira

    Nat Immunol, 11 (10), 936-944, 2010.
17. Polyubiquitin conjugation to NEMO by triparite motif protein 23 (TRIM23) is critical in antiviral defense.

    Kei-ichiro Arimoto, Kenji Funami, Yasushi Saeki, Keiji Tanaka, Katsuya Okawa, Osamu Takeuchi, Shizuo Akira, Yoshiki Murakami and Kunitada Shimotohno

    Proc Natl Acad Sci U S A, 107 (36), 15856-15861, 2010.
18. Autophagy requires endoplasmic reticulum targeting of the PI3-kinase complex via Atg14L.

    Kohichi Matsunaga, Eiji Morita, Tatsuya Saitoh, Shizuo Akira, Nicholas T Ktistakis, Tetsuro Izumi, Takeshi Noda and Tamotsu Yoshimori

    J Cell Biol, 190 (4), 511-521, 2010.
19. Influenza A virus polymerase inhibits type I interferon induction by binding to interferon β promoter stimulator 1.

    Atsushi Iwai, Takuya Shiozaki, Taro Kawai, Shizuo Akira, Yoshihiro Kawaoka, Ayato Takada, Hiroshi Kida and Tadaaki Miyazaki

    J Biol Chem, 285 (42), 32064-32074, 2010.
20. Telomere-mediated chromosomal instability triggers TLR4 induced inflammation and death in mice.

    Rabindra N Bhattacharjee, Birendranath Banerjee, Shizuo Akira and M Prakash Hande

    PLoS One, 5 (7), e11873, 2010.
21. c-Jun mediates hepatitis C virus hepatocarcinogenesis through signal transducer and activator of transcription 3 and nitric oxide-dependent impairment of oxidative DNA repair.

    Keigo Machida, Hidekazu Tsukamoto, Jian-Chang Liu, Yuan-Ping Han, Sugantha Govindarajan, Michael M C Lai, Shizuo Akira and Jing-Hsiung James Ou

    Hepatology, 52 (2), 480-492, 2010.
22. Lipid A Receptor TLR4-Mediated Signaling Pathways.

    Masahiro Yamamoto and Shizuo Akira

    Adv Exp Med Biol, 667, 59-68, 2010.
23. E2 Polyubiquitin-conjugating enzyme Ubc13 in keratinocytes is essential for epidermal integrity.

    Koji Sayama, Masahiro Yamamoto, Yuji Shirakata, Yasushi Hanakawa, Satoshi Hirakawa, Xiuju Dai, Mikiko Tohyama, Sho Tokumaru, Myoung-Sook Shin, Hiroaki Sakurai, Shizuo Akira and Koji Hashimoto

    J Biol Chem, 285 (39), 30042-30049, 2010.
24. Pathways regulating cytosolic phospholipase A2 activation and eicosanoid production in macrophages by Candida albicans.

    Saritha Suram, Todd A Gangelhoff, Philip R Taylor, Marcela Rosas, Gordon D Brown, Joseph V Bonventre, Shizuo Akira, Satoshi Uematsu, David L Williams, Robert C Murphy and Christina C Leslie

    J Biol Chem, 285 (40), 30676-30685, 2010.
25. TLR9 and endogenous adjuvants of the whole blood-stage malaria vaccine.

    Cevayir Coban, Toshihiro Horii, Shizuo Akira and Ken J Ishii

    Expert Rev Vaccines, 9 (7), 775-784, 2010.
26. Microsomal prostaglandin E synthase-1 contributes to ischaemic excitotoxicity through prostaglandin E2 EP3 receptors.

    Y Ikeda-Matsuo, H Tanji, A Ota, Y Hirayama, S Uematsu, S Akira and Y Sasaki

    Br J Pharmacol, 160 (4), 847-859, 2010.
27. Inflammatory mediator TAK1 regulates hair follicle morphogenesis and anagen induction shown by using keratinocyte-specific TAK1-deficient mice.

    Koji Sayama, Kentaro Kajiya, Koji Sugawara, Shintaro Sato, Satoshi Hirakawa, Yuji Shirakata, Yasushi Hanakawa, Xiuju Dai, Yumiko Ishimatsu-Tsuji, Daniel Metzger, Pierre Chambon, Shizuo Akira, Ralf Paus, Jiro Kishimoto and Koji Hashimoto

    PLoS One, 5 (6), e11275, 2010.
28. A role for granzyme M in TLR4-driven inflammation and endotoxicosis.

    Desiree A Anthony, Daniel M Andrews, Melvyn Chow, Sally V Watt, Colin House, Shizuo Akira, Phillip I Bird, Joseph A Trapani and Mark J Smyth

    J Immunol, 185 (3), 1794-1803, 2010.
29. Regulation of innate immune responses by autophagy-related proteins.

    Tatsuya Saitoh and Shizuo Akira

    J Cell Biol, 189 (6), 925-935, 2010.
30. A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release.

    Huan Yang, Hulda S Hreggvidsdottir, Karin Palmblad, Haichao Wang, Mahendar Ochani, Jianhua Li, Ben Lu, Sangeeta Chavan, Mauricio Rosas-Ballina, Yousef Al-Abed, Shizuo Akira, Angelika Bierhaus, Helena Erlandsson-Harris, Ulf Andersson and Kevin J Tracey

    Proc Natl Acad Sci U S A, 107 (26), 11942-11947, 2010.
31. Control of adipose tissue inflammation through TRB1.

    Anke Ostertag, Allan Jones, Adam J Rose, Maria Liebert, Stefan Kleinsorg, Anja Reimann, Alexandros Vegiopoulos, Mauricio Berriel Diaz, Daniela Strzoda, Masahiro Yamamoto, Takashi Satoh, Shizuo Akira and Stephan Herzig

    Diabetes, 59 (8), 1991-2000, 2010.
32. Dectin-2 Recognition of alpha-Mannans and Induction of Th17 Cell Differentiation Is Essential for Host Defense against Candida albicans.

    Shinobu Saijo, Satoshi Ikeda, Keiko Yamabe, Shigeru Kakuta, Harumichi Ishigame, Aoi Akitsu, Noriyuki Fujikado, Toshimasa Kusaka, Sachiko Kubo, Soo-Hyun Chung, Ryohei Komatsu, Noriko Miura, Yoshiyuki Adachi, Naohito Ohno, Kazutoshi Shibuya, Natsuo Yamamoto, Kazuyoshi Kawakami, Sho Yamasaki, Takashi Saito, Shizuo Akira and Yoichiro Iwakura

    Immunity, 32 (5), 681-691, 2010.
33. Protein kinase R contributes to immunity against specific viruses by regulating interferon mRNA integrity.

    Oliver Schulz, Andreas Pichlmair, Jan Rehwinkel, Neil C Rogers, Donalyn Scheuner, Hiroki Kato, Osamu Takeuchi, Shizuo Akira, Randal J Kaufman and Caetano Reis e Sousa

    Cell Host Microbe, 7 (5), 354-361, 2010.
34. TAK1 suppresses a NEMO-dependent but NF-kappaB-independent pathway to liver cancer.

    Kira Bettermann, Mihael Vucur, Johannes Haybaeck, Christiane Koppe, Jörn Janssen, Felix Heymann, Achim Weber, Ralf Weiskirchen, Christian Liedtke, Nikolaus Gassler, Michael Müller, Rita de Vos, Monika Julia Wolf, Yannick Boege, Gitta Maria Seleznik, Nicolas Zeller, Daniel Erny, Thomas Fuchs, Stefan Zoller, Stefano Cairo, Marie-Annick Buendia, Marco Prinz, Shizuo Akira, Frank Tacke, Mathias Heikenwalder, Christian Trautwein and Tom Luedde

    Cancer Cell, 17 (5), 481-496, 2010.
35. mPGES-1-expressing bone marrow-derived cells enhance tumor growth and angiogenesis in mice.

    Hiroki Kamata, Kanako Hosono, Tatsunori Suzuki, Yasufumi Ogawa, Hidefumi Kubo, Hiroshi Katoh, Yoshiya Ito, Satoshi Uematsu, Shizuo Akira, Masahiko Watanabe and Masataka Majima

    Biomed Pharmacother, 64 (6), 409-416, 2010.
36. The role of multiple toll-like receptor signalling cascades on interactions between biomedical polymers and dendritic cells.

    Behnaz Shokouhi, Cevayir Coban, Vasif Hasirci, Erkin Aydin, Anandhan Dhanasingh, Nian Shi, Shohei Koyama, Shizuo Akira, Martin Zenke and Antonio S Sechi

    Biomaterials, 31 (22), 5759-5771, 2010.
37. Activation of myeloid dendritic cells by deoxynucleic acids from Cordyceps sinensis via a Toll-like receptor 9-dependent pathway.

    Gang Xiao, Akiko Miyazato, Yuzuru Abe, Tiantuo Zhang, Kiwamu Nakamura, Ken Inden, Misuzu Tanaka, Daiki Tanno, Tomomitsu Miyasaka, Keiko Ishii, Kiyoshi Takeda, Shizuo Akira, Shinobu Saijo, Yoichiro Iwakura, Yoshiyuki Adachi, Naohito Ohno, Natsuo Yamamoto, Hiroyuki Kunishima, Yoichi Hirakata, Mitsuo Kaku and Kazuyoshi Kawakami

    Cell Immunol, 263 (2), 241-250, 2010.
38. Plasmacytoid dendritic cells delineate immunogenicity of influenza vaccine subtypes.

    Shohei Koyama, Taiki Aoshi, Takeshi Tanimoto, Yutaro Kumagai, Kouji Kobiyama, Takahiro Tougan, Kazuo Sakurai, Cevayir Coban, Toshihiro Horii, Shizuo Akira and Ken J Ishii

    Sci Transl Med, 2 (25), 25ra24, 2010.
39. The malarial metabolite hemozoin and its potential use as a vaccine adjuvant.

    Cevayir Coban, Masanori Yagi, Keiichi Ohata, Yoshikatsu Igari, Toshihiro Tsukui, Toshihiro Horii, Ken J Ishii and Shizuo Akira

    Allergol Int, 59 (2), 115-124, 2010.
40. The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors.

    Taro Kawai and Shizuo Akira

    Nat Immunol, 11 (5), 373-384, 2010.
41. Identification and functions of pattern-recognition receptors.

    Yutaro Kumagai and Shizuo Akira

    J Allergy Clin Immunol, 125 (5), 985-992, 2010.
42. IkappaBzeta regulates T(H)17 development by cooperating with ROR nuclear receptors.

    Kazuo Okamoto, Yoshiko Iwai, Masatsugu Oh-Hora, Masahiro Yamamoto, Tomohiro Morio, Kazuhiro Aoki, Keiichi Ohya, Anton M Jetten, Shizuo Akira, Tatsushi Muta and Hiroshi Takayanagi

    Nature, 464 (7293), 1381-1385, 2010.
43. Pathogenic Vibrio Activate NLRP3 Inflammasome via Cytotoxins and TLR/Nucleotide-Binding Oligomerization Domain-Mediated NF-κB Signaling.

    Claudia Toma, Naomi Higa, Yukiko Koizumi, Noboru Nakasone, Yasunori Ogura, Andrea J McCoy, Luigi Franchi, Satoshi Uematsu, Junji Sagara, Shun'ichiro Taniguchi, Hiroko Tsutsui, Shizuo Akira, Jürg Tschopp, Gabriel Núñez and Toshihiko Suzuki

    J Immunol, 184 (9), 5287-5297, 2010.
44. Human lactoferrin activates NF-kappaB through the Toll-like receptor 4 pathway while it interferes with the lipopolysaccharide-stimulated TLR4 signaling.

    Ken Ando, Keiichi Hasegawa, Ken-Ichi Shindo, Tomoyasu Furusawa, Tomofumi Fujino, Kiyomi Kikugawa, Hiroyasu Nakano, Osamu Takeuchi, Shizuo Akira, Taishin Akiyama, Jin Gohda, Jun-Ichiro Inoue and Makio Hayakawa

    FEBS J, 277 (9), 2051-2066, 2010.
45. Pattern recognition receptors and inflammation.

    Osamu Takeuchi and Shizuo Akira

    Cell, 140 (6), 805-820, 2010.
46. Regulation of dsDNA-induced innate immune responses by membrane trafficking.

    Tatsuya Saitoh, Naonobu Fujita, Tamotsu Yoshimori and Shizuo Akira

    Autophagy, 6 (3), 430-432, 2010.
47. An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence.

    Michael Berger, Philippe Krebs, Karine Crozat, Xiaohong Li, Ben A Croker, Owen M Siggs, Daniel Popkin, Xin Du, Brian R Lawson, Argyrios N Theofilopoulos, Yu Xia, Kevin Khovananth, Eva Marie Y Moresco, Takashi Satoh, Osamu Takeuchi, Shizuo Akira and Bruce Beutler

    Nat Immunol, 11 (4), 335-343, 2010.
48. Quantitative proteomics reveals subset-specific viral recognition in dendritic cells.

    Christian A Luber, Jürgen Cox, Henning Lauterbach, Ben Fancke, Matthias Selbach, Jurg Tschopp, Shizuo Akira, Marian Wiegand, Hubertus Hochrein, Meredith O'Keeffe and Matthias Mann

    Immunity, 32 (2), 279-289, 2010.
49. Cutting edge: bacterial infection induces hematopoietic stem and progenitor cell expansion in the absence of TLR signaling.

    Philip O Scumpia, Kindra M Kelly-Scumpia, Matthew J Delano, Jason S Weinstein, Alex G Cuenca, Samer Al-Quran, Ian Bovio, Shizuo Akira, Yutaro Kumagai and Lyle L Moldawer

    J Immunol, 184 (5), 2247-2251, 2010.
50. Microsomal prostaglandin E synthase-1 and cyclooxygenase-2 are both required for ischaemic excitotoxicity.

    Y Ikeda-Matsuo, Y Hirayama, A Ota, S Uematsu, S Akira and Y Sasaki

    Br J Pharmacol, 159 (5), 1174-1186, 2010.
51. Intracellular Mycobacterium avium intersect transferrin in the Rab11(+) recycling endocytic pathway and avoid lipocalin 2 trafficking to the lysosomal pathway.

    Oyvind Halaas, Magnus Steigedal, Markus Haug, Jane A Awuh, Liv Ryan, Andreas Brech, Shintaro Sato, Harald Husebye, Gerard A Cangelosi, Shizuo Akira, Roland K Strong, Terje Espevik and Trude H Flo

    J Infect Dis, 201 (5), 783-792, 2010.
52. Immunogenicity of whole-parasite vaccines against Plasmodium falciparum involves malarial hemozoin and host TLR9.

    Cevayir Coban, Yoshikatsu Igari, Masanori Yagi, Thornik Reimer, Shohei Koyama, Taiki Aoshi, Keiichi Ohata, Toshihiro Tsukui, Fumihiko Takeshita, Kazuo Sakurai, Takahisa Ikegami, Atsushi Nakagawa, Toshihiro Horii, Gabriel Nuñez, Ken J Ishii and Shizuo Akira

    Cell Host Microbe, 7 (1), 50-61, 2010.
53. Disruption of TAK1 in hepatocytes causes hepatic injury, inflammation, fibrosis, and carcinogenesis.

    Sayaka Inokuchi, Tomonori Aoyama, Kouichi Miura, Christoph H Osterreicher, Yuzo Kodama, Katsumi Miyai, Shizuo Akira, David A Brenner and Ekihiro Seki

    Proc Natl Acad Sci U S A, 107 (2), 844-849, 2010.
54. LGP2 is a positive regulator of RIG-I- and MDA5-mediated antiviral responses.

    Takashi Satoh, Hiroki Kato, Yutaro Kumagai, Mitsutoshi Yoneyama, Shintaro Sato, Kazufumi Matsushita, Tohru Tsujimura, Takashi Fujita, Shizuo Akira and Osamu Takeuchi

    Proc Natl Acad Sci U S A, 107 (4), 1512-1517, 2010.
55. Toll-like receptor 6 drives interleukin-17A expression during experimental hypersensitivity pneumonitis.

    Daniel J Fong, Cory M Hogaboam, Yosuke Matsuno, Shizuo Akira, Satoshi Uematsu and Amrita D Joshi

    Immunology, 130 (1), 125-136, 2010.
56. Plasmacytoid dendritic cell-derived type I interferon is crucial for the adjuvant activity of Toll-like receptor 7 agonists.

    Deepa Rajagopal, Carine Paturel, Yannis Morel, Satoshi Uematsu, Shizuo Akira and Sandra S Diebold

    Blood, 115 (10), 1949-1957, 2010.
57. TLR2-Dependent Inflammatory Response to Porphyromonas gingivalis Is MyD88 Independent, whereas MyD88 Is Required To Clear Infection.

    Elia Burns, Tal Eliyahu, Satoshi Uematsu, Shizuo Akira and Gabriel Nussbaum

    J Immunol, 184 (3), 1455-1462, 2010.
58. Prostaglandin E(2) exerts homeostatic regulation of pulmonary vascular remodeling in allergic airway inflammation.

    Anders Lundequist, Samridhi N Nallamshetty, Wei Xing, Chunli Feng, Tanya M Laidlaw, Satoshi Uematsu, Shizuo Akira and Joshua A Boyce

    J Immunol, 184 (1), 433-441, 2010.
59. Ablation of C/EBPbeta alleviates ER stress and pancreatic beta cell failure through the GRP78 chaperone in mice.

    Tomokazu Matsuda, Yoshiaki Kido, Shun-ichiro Asahara, Tsuneyasu Kaisho, Takashi Tanaka, Naoko Hashimoto, Yutaka Shigeyama, Akihiko Takeda, Tae Inoue, Yuki Shibutani, Maki Koyanagi, Tetsuya Hosooka, Michihiro Matsumoto, Hiroshi Inoue, Tohru Uchida, Masato Koike, Yasuo Uchiyama, Shizuo Akira and Masato Kasuga

    J Clin Invest, 120 (1), 115-126, 2010.
60. Transforming growth factor beta-activated kinase 1 (TAK1) kinase adaptor, TAK1-binding protein 2, plays dual roles in TAK1 signaling by recruiting both an activator and an inhibitor of TAK1 kinase in tumor necrosis factor signaling pathway.

    Peter Broglie, Kunihiro Matsumoto, Shizuo Akira, David L Brautigan and Jun Ninomiya-Tsuji

    J Biol Chem, 285 (4), 2333-2339, 2010.
61. Experimental Cerebral Malaria Progresses Independently of the Nlrp3 Inflammasome.

    Thornik Reimer, Michael H Shaw, Luigi Franchi, Cevayir Coban, Ken J Ishii, Shizuo Akira, Toshihiro Horii, Ana Rodriguez and Gabriel Núñez

    Eur J Immunol, 40 (3), 764-769, 2010.
62. Critical role of TLR7 in the acceleration of systemic lupus erythematosus in TLR9-deficient mice.

    Marie-Laure Santiago-Raber, Isabelle Dunand-Sauthier, Tianfu Wu, Quan-Zhen Li, Satoshi Uematsu, Shizuo Akira, Walter Reith, Chandra Mohan, Brian L Kotzin and Shozo Izui

    J Autoimmun, 34 (4), 339-348, 2010.
63. Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1 beta production.

    Hendrik Poeck, Michael Bscheider, Olaf Gross, Katrin Finger, Susanne Roth, Manuele Rebsamen, Nicole Hannesschläger, Martin Schlee, Simon Rothenfusser, Winfried Barchet, Hiroki Kato, Shizuo Akira, Satoshi Inoue, Stefan Endres, Christian Peschel, Gunther Hartmann, Veit Hornung and Jürgen Ruland

    Nat Immunol, 11 (1), 63-69, 2010.
64. TLR7 modulates anti-nucleosomal autoantibody isotype and renal complement deposition in mice exposed to syngeneic late apoptotic cells.

    Zi-Jian Pan, Shannon Maier, Karen Schwarz, Jennifer Azbill, Shizuo Akira, Satoshi Uematsu and A Darise Farris

    Ann Rheum Dis, 69 (6), 1195-1199, 2010.
65. Endothelial microsomal prostaglandin E synthase-1 exacerbates neuronal loss induced by kainate.

    Takako Takemiya, Kiyoshi Matsumura, Hiroko Sugiura, Michiyo Maehara, Shin Yasuda, Satoshi Uematsu, Shizuo Akira and Kanato Yamagata

    J Neurosci Res, 88 (2), 381-390, 2010.

Link

http://www.biken.osaka-u.ac.jp/