Laboratory for Viral Pathogenesis and Immunity

Subjects:

1. Analysis of the molecular mechanisms involved in influenza virus (Flu) cytotoxicity and virulency.
2. Development of Pathogen Identification System by high-throughput “Next-Generation” DNA sequencer (RAPID system; Collaborative work).
3. Genetic engineering of recombinant Flu and Newcastle disease irus (NDV).

Published Papers

1. Broad and potent anti-influenza virus spectrum of epigallocatechin-3-O-gallate-monopalmitate.

   Kunihiro Kaihatsu, Shuichi Mori, Hiroyo Matsumura, Tomo Daidoji, Chiharu Kawakami, Hideshi Kurata, Takaaki Nakaya and Nobuo Kato

   J Mol Genet Med, 3 (2), 195-197, 2009.
2. Direct metagenomic detection of viral pathogens in nasal and fecal specimens using an unbiased high-throughput sequencing approach.

   Shota Nakamura, Cheng-Song Yang, Naomi Sakon, Mayo Ueda, Takahiro Tougan, Akifumi Yamashita, Naohisa Goto, Kazuo Takahashi, Teruo Yasunaga, Kazuyoshi Ikuta, Tetsuya Mizutani, Yoshiko Okamoto, Michihira Tagami, Ryoji Morita, Norihiro Maeda, Jun Kawai, Yoshihide Hayashizaki, Yoshiyuki Nagai, Toshihiro Horii, Tetsuya Iida and Takaaki Nakaya

   PLoS ONE, 4 (1), e4219, 2009.
3. Detection of circulating Asian H5N1 viruses by a newly established monoclonal antibody.

   Anariwa Du, Tomo Daidoji, Takaaki Koma, Madiha S Ibrahim, Shota Nakamura, U Chandimal de Silva, Mayo Ueda, Cheng-Song Yang, Teruo Yasunaga, Kazuyoshi Ikuta and Takaaki Nakaya

   Biochem Biophys Res Commun, 378 (2), 197-202, 2009.

Link

http://www.biken.osaka-u.ac.jp/