Department of Immunoregulation

Subjects:

1. Biochemistry and molecular biology of biosynthesis pathway of GPI-anchored proteins.
2. Molecular pathogenesis of a GPI-anchor deficiencies, paroxysmal nocturnal hemoglobinuria and inherited GPI deficiency.
3. Roles of GPI in microorganisms.

Published Papers

1. Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle.

   Eri Ishikawa, Tetsuaki Ishikawa, Yasu S Morita, Kenji Toyonaga, Hisakata Yamada, Osamu Takeuchi, Taroh Kinoshita, Shizuo Akira, Yasunobu Yoshikai and Sho Yamasaki

   J Exp Med, 206 (13), 2879-2888, 2009.
2. Integrin-linked kinase associated with integrin activation.

   Shigenori Honda, Hiroko Shirotani-Ikejima, Seiji Tadokoro, Yusuke Maeda, Taroh Kinoshita, Yoshiaki Tomiyama and Toshiyuki Miyata

   Blood, 113 (21), 5304-5313, 2009.
3. Enhanced humoral immune responses against T-independent antigens in Fc alpha/muR-deficient mice.

   Shin-ichiro Honda, Naoki Kurita, Akitomo Miyamoto, Yukiko Cho, Kenta Usui, Kie Takeshita, Satoru Takahashi, Teruhito Yasui, Hitoshi Kikutani, Taroh Kinoshita, Teizo Fujita, Satoko Tahara-Hanaoka, Kazuko Shibuya and Akira Shibuya

   Proc Natl Acad Sci U S A, 106 (27), 11230-11235, 2009.
4. Peroxisome dependency of alkyl-containing GPI-anchor biosynthesis in the endoplasmic reticulum.

   Noriyuki Kanzawa, Yusuke Maeda, Hideo Ogiso, Yoshiko Murakami, Ryo Taguchi and Taroh Kinoshita

   Proc Natl Acad Sci U S A, 106 (42), 17711-17716, 2009.
5. Overview of GPI biosynthesis.

   T Kinoshita and M Fujita

   In The Enzymes, Menon, A.K., Kinoshita, T., Orlean, P. and Tamanoi, F., Eds., Academic Press, Burlington, 26, 1-30, 2009.
6. Mannosylation.

   Yusuke Maeda and Yasu S Morita

   In The Enzymes, Menon, A.K., Kinoshita, T., Orlean, P. and Tamanoi, F., Eds., Academic Press, Burlington, 26, 91-115, 2009.
7. Trypanosome glycosylphosphatidylinositol biosynthesis.

   Yeonchul Hong and Taroh Kinoshita

   Korean J Parasitol, 47 (3), 197-204, 2009.
8. GPI glycan remodeling by PGAP5 regulates transport of GPI-anchored proteins from the ER to the Golgi.

   Morihisa Fujita, Yusuke Maeda, Moonjin Ra, Yoshiki Yamaguchi, Ryo Taguchi and Taroh Kinoshita

   Cell, 139 (2), 352-365, 2009.
9. Deficiency of Dol-P-Man synthase subunit DPM3 bridges the congenital disorders of glycosylation with the dystroglycanopathies.

   Dirk J Lefeber, Johannes Schönberger, Eva Morava, Mailys Guillard, Karin M Huyben, Kiek Verrijp, Olga Grafakou, Athanasios Evangeliou, Frank W Preijers, Panagiota Manta, Jef Yildiz, Stephanie Grünewald, Martha Spilioti, Christa van den Elzen, Dominique Klein, Daniel Hess, Hisashi Ashida, Jan Hofsteenge, Yusuke Maeda, Lambert van den Heuvel, Martin Lammens, Ludwig Lehle and Ron A Wevers

   Am J Hum Genet, 85 (1), 76-86, 2009.
10. Testicular Angiotensin-Converting Enzyme with Different Glycan Modification: Characterization on Glycosylphosphatidylinositol-Anchored Protein Releasing and Dipeptidase Activities.

    Gen Kondoh, Hitomi Watanabe, Yuko Tashima, Yusuke Maeda and Taroh Kinoshita

    J Biochem, 145 (1), 115-121, 2009.

Link

http://www.biken.osaka-u.ac.jp/