Department of Immunochemistry

Subjects:

1. Role of paired receptors on host defense.
2. Mechanism of virus entry into cells.
3. Analysis of molecules involved in host-pathogen interaction.

Published Papers

1. Binding of herpes simplex virus glycoprotein B (gB) to PILRα depends on specific sialylated O-linked glycans on gB.

   Jing Wang, Qing Fan, Takeshi Satoh, Jun Arii, Lewis L Lanier, Patricia G Spear, Yasushi Kawaguchi and Hisashi Arase

   J Virol, 83 (24), 13042-13045, 2009.
2. The study of regulatory T cells and NKT cells in Japan: a historical perspective.

   Hisashi Arase and Ken-ichiro Seino

   Int Immunol, 21 (10), 1101-1103, 2009.
3. Differential effects on cell fusion activity of mutations in herpes simplex virus 1 glycoprotein B (gB) dependent on whether a gD receptor or a gB receptor is overexpressed.

   Qing Fan, Erick Lin, Takeshi Satoh, Hisashi Arase and Patricia G Spear

   J Virol, 83 (15), 7384-7390, 2009.
4. Ly49Q ligand expressed by activated B cells induces plasmacytoid DC maturation.

   Makiko Toma-Hirano, Sahori Namiki, Yasue Shibata, Koji Ishida, Hisashi Arase, Shoichiro Miyatake, Ken-ichi Arai and Yumiko Kamogawa-Schifter

   Eur J Immunol, 39 (5), 1344-1352, 2009.
5. Ly49H signaling through DAP10 is essential for optimal natural killer cell responses to mouse cytomegalovirus infection.

   Mark T Orr, Joseph C Sun, David G T Hesslein, Hisashi Arase, Joseph H Phillips, Toshiyuki Takai and Lewis L Lanier

   J Exp Med, 206 (4), 807-817, 2009.
6. Entry of herpes simplex virus 1 and other alphaherpesviruses via the paired immunoglobulin-like type 2 receptor alpha.

   Jun Arii, Masashi Uema, Tomomi Morimoto, Hiroshi Sagara, Hiroomi Akashi, Etsuro Ono, Hisashi Arase and Yasushi Kawaguchi

   J Virol, 83 (9), 4520-4527, 2009.
7. Herpes simplex virus 1 protein kinase Us3 phosphorylates viral envelope glycoprotein B and regulates its expression on the cell surface.

   Akihisa Kato, Jun Arii, Ikuo Shiratori, Hiroomi Akashi, Hisashi Arase and Yasushi Kawaguchi

   J Virol, 83 (1), 250-261, 2009.

Link

http://www.biken.osaka-u.ac.jp/