Department of Cellular Regulation

Subjects:

1. Cell biological analysis on molecular mechanism of autophagy.
2. Elucidation of physiological role of autophagy.
3. Molecular dissection of endocytic pathway.

Published Papers

1. An initial step of GAS-containing autophagosome-like vacuoles formation requires Rab7.

   Hitomi Yamaguchi, Ichiro Nakagawa, Akitsugu Yamamoto, Atsuo Amano, Takeshi Noda and Tamotsu Yoshimori

   PLoS Pathog, 5 (11), e1000670, 2009.
2. Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response.

   Tatsuya Saitoh, Naonobu Fujita, Takuya Hayashi, Keigo Takahara, Takashi Satoh, Hanna Lee, Kohichi Matsunaga, Shun Kageyama, Hiroko Omori, Takeshi Noda, Naoki Yamamoto, Taro Kawai, Ken Ishii, Osamu Takeuchi, Tamotsu Yoshimori and Shizuo Akira

   Proc Natl Acad Sci U S A, 106 (49), 20842-20846, 2009.
3. A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation.

   Mitsuko Hayashi-Nishino, Naonobu Fujita, Takeshi Noda, Akihito Yamaguchi, Tamotsu Yoshimori and Akitsugu Yamamoto

   Nat Cell Biol, 11 (12), 1433-1437, 2009.
4. The stent-eluting drugs sirolimus and paclitaxel suppress healing of the endothelium by induction of autophagy.

   Shin-ichiro Hayashi, Akitsugu Yamamoto, Fukka You, Kentaro Yamashita, Yuka Ikegame, Masahiro Tawada, Tamotsu Yoshimori, Shigeomi Shimizu and Shigeru Nakashima

   Am J Pathol, 175 (5), 2226-2234, 2009.
5. Group a Streptococcus: a loser in the battle with autophagy.

   Tamotsu Yoshimori and Atsuo Amano

   Curr Top Microbiol Immunol, 335, 217-226, 2009.
6. Differencial involvement of ATG16L1 in Crohn's disease and canonical autophagy: analysis of the organization of the ATG16L1 complex in fibroblasts.

   Naonobu Fujita, Tatsuya Saitoh, Shun Kageyama, Shizuo Akira, Takeshi Noda and Tamotsu Yoshimori

   J Biol Chem, 284 (47), 32602-32609, 2009.
7. Molecular basis of canonical and bactericidal autophagy.

   Takeshi Noda and Tamotsu Yoshimori

   Int Immunol, 21 (11), 1199-1204, 2009.
8. Cochaperone activity of human butyrate-induced transcript 1 facilitates hepatitis C virus replication through an Hsp90-dependent pathway.

   Shuhei Taguwa, Hiroto Kambara, Hiroko Omori, Hideki Tani, Takayuki Abe, Yoshio Mori, Tetsuro Suzuki, Tamotsu Yoshimori, Kohji Moriishi and Yoshiharu Matsuura

   J Virol, 83 (20), 10427-10436, 2009.
9. Porphyromonas gingivalis outer membrane vesicles enter human epithelial cells via an endocytic pathway and are sorted to lysosomal compartments.

   Nobumichi Furuta, Kayoko Tsuda, Hiroko Omori, Tamotsu Yoshimori, Fuminobu Yoshimura and Atsuo Amano

   Infect Immun, 77 (10), 4187-4196, 2009.
10. Binding Rubicon to cross the Rubicon.

    Kohichi Matsunaga, Takeshi Noda and Tamotsu Yoshimori

    Autophagy, 5 (6), 876-877, 2009.
11. The late stages of autophagy: how does the end begin?

    T Noda, N Fujita and T Yoshimori

    Cell Death Differ, 16, 984-990, 2009.
12. Autophagic elimination of misfolded procollagen aggregates in the endoplasmic reticulum as a means of cell protection.

    Yoshihito Ishida, Akitsugu Yamamoto, Akira Kitamura, Shireen R Lamandé, Tamotsu Yoshimori, John F Bateman, Hiroshi Kubota and Kazuhiro Nagata

    Mol Biol Cell, 20 (11), 2744-2754, 2009.
13. Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages.

    Kohichi Matsunaga, Tatsuya Saitoh, Keisuke Tabata, Hiroko Omori, Takashi Satoh, Ikuko Maejima, Kanae Shirahama-Noda, Tohru Ichimura, Toshiaki Isobe, Shizuo Akira, Takeshi Noda and Tamotsu Yoshimori

    Nat Cell Biol, 11 (4), 385-396, 2009.
14. Monitoring autophagy in mammalian cultured cells through the dynamics of LC3.

    Shunsuke Kimura, Naonobu Fujita, Takeshi Noda and Tamotsu Yoshimori

    Methods Enzymol, 452, 1-12, 2009.
15. Effect of Helicobacter pylori's vacuolating cytotoxin on the autophagy pathway in gastric epithelial cells.

    Mauricio R Terebiznik, Deepa Raju, Cristina L Vázquez, Karl Torbricki, Reshma Kulkarni, Steven R Blanke, Tamotsu Yoshimori, María I Colombo and Nicola L Jones

    Autophagy, 5 (3), 370-379, 2009.
16. Atg4B(C74A) hampers autophagosome closure: a useful protein for inhibiting autophagy.

    Naonobu Fujita, Takeshi Noda and Tamotsu Yoshimori

    Autophagy, 5 (1), 88-89, 2009.

Link

http://www.biken.osaka-u.ac.jp/