Department of Virology

Subjects:

1. Pathogenesis of human immunodeficiency virus type 1.
2. Epidemiological, virological and molecular-biological characterization of Borna disease virus.
3. Mechanism of prion-induced pathogenesis in model systems.

Published Papers

1. Establishment of a new glial cell line from hippocampus of prion protein gene-deficient mice.

   Takuya Nishimura, Akikazu Sakudo, Guangai Xue, Kazuyoshi Ikuta, Masayoshi Yukawa, Katsuaki Sugiura and Takashi Onodera

   Biochem Biophys Res Commun, 377 (4), 1047-1050, 2008.
2. Efficient capture of infectious H5 avian influenza virus utilizing magnetic beads coated with anionic polymer.

   Akikazu Sakudo and Kazuyoshi Ikuta

   Biochem Biophys Res Commun, 377 (1), 85-88, 2008.
3. Visible and near-infrared spectral changes in plasma of psychiatric patients.

   Yukiko Hakariya Kato, Hidenori Matsunaga, Akikazu Sakudo and Kazuyoshi Ikuta

   Int J Mol Med, 22 (4), 513-519, 2008.
4. H5N1 avian influenza virus induces apoptotic cell death in mammalian airway epithelial cells.

   Tomo Daidoji, Takaaki Koma, Anariwa Du, Cheng-Song Yang, Mayo Ueda, Kazuyoshi Ikuta and Takaaki Nakaya

   J Virol, 82 (22), 11294-11307, 2008.
5. Isotype analysis of human anti-Borna disease virus antibodies in Japanese psychiatric and general population.

   Hidenori Matsunaga, Susumu Tanaka, Akio Fukumori, Keizo Tomonaga, Kazuyoshi Ikuta, Nobuyuki Amino and Masatoshi Takeda

   J Clin Virol, 43 (3), 317-322, 2008.
6. Ribavirin inhibits Borna disease virus proliferation and fatal neurological diseases in neonatally infected gerbils.

   Byeong-Jae Lee, Hidenori Matsunaga, Kazuyoshi Ikuta and Keizo Tomonaga

   Antiviral Res, 80 (3), 380-384, 2008.
7. Extent of hepatitis E virus elimination is affected by stabilizers present in plasma products and pore size of nanofilters.

   M Yunoki, S Yamamoto, H Tanaka, H Nishigaki, Y Tanaka, A Nishida, J Adan-Kubo, M Tsujikawa, S Hattori, T Urayama, M Yoshikawa, I Yamamoto, K Hagiwara and K Ikuta

   Vox Sang, 95 (2), 94-100, 2008.
8. Maturation efficiency of viral glycoproteins in the ER impacts the production of influenza A virus.

   Mayo Ueda, Masanobu Yamate, Anariwa Du, Tomo Daidoji, Yoshinobu Okuno, Kazuyoshi Ikuta and Takaaki Nakaya

   Virus Res, 136 (1-2), 91-97, 2008.
9. Higher in vitro susceptibility of human T cells to H5N1 than H1N1 influenza viruses.

   Yong-Gang Li, Pranee Thawatsupha, Malinee Chittaganpitch, Kamonthip Rungrojcharoenkit, Gui-Mei Li, Takaaki Nakaya, Wattana Auwanit, Kazuyoshi Ikuta and Pathom Sawanpanyalert

   Biochem Biophys Res Commun, 371 (3), 484-489, 2008.
10. Superinfection of defective human immunodeficiency virus type 1 with different subtypes of wild-type virus efficiently produces infectious variants with the initial viral phenotypes by complementation followed by recombination.

    Yukie Iwabu, Hiroyuki Mizuta, Michiko Kawase, Masanori Kameoka, Toshiyuki Goto and Kazuyoshi Ikuta

    Microbes Infect, 10 (5), 504-513, 2008.
11. Reduced incorporation of SARS-CoV spike protein into viral particles due to amino acid substitutions within the receptor binding domain.

    Shu-Ming Li, Gui-Mei Li, Shota Nakamura, Kazuyoshi Ikuta and Takaaki Nakaya

    Jpn J Infect Dis, 61 (2), 123-127, 2008.
12. Normal cytochrome C oxidase activity in prion protein gene-deficient mice.

    Akikazu Sakudo, Yojiro Taniuchi, Takanori Kobayashi, Takashi Onodera and Kazuyoshi Ikuta

    Protein Pept Lett, 15 (3), 250-254, 2008.
13. GPI-anchorless human prion protein is secreted and glycosylated but lacks superoxide dismutase activity.

    Akikazu Sakudo, Izuru Nakamura, Shotaro Tsuji and Kazuyoshi Ikuta

    Int J Mol Med, 21 (2), 217-222, 2008.
14. Inhibitory function of adapter-related protein complex 2 alpha 1 subunit in the process of nuclear translocation of human immunodeficiency virus type 1 genome.

    Yukiko Kitagawa, Masanori Kameoka, Sanae Shoji-Kawata, Yukie Iwabu, Hiroyuki Mizuta, Kenzo Tokunaga, Masato Fujino, Yukikazu Natori, Yoshiaki Yura and Kazuyoshi Ikuta

    Virology, 373 (1), 171-180, 2008.
15. PrPSc level and incubation time in a transgenic mouse model expressing Borna disease virus phosphoprotein after intracerebral prion infection.

    Akikazu Sakudo, Takashi Onodera and Kazuyoshi Ikuta

    Neurosci Lett, 431 (1), 81-85, 2008.
16. Octapeptide repeat region of prion protein (PrP) is required at an early stage for production of abnormal prion protein in PrP-deficient neuronal cell line.

    Akikazu Sakudo, Guoying Wu, Takashi Onodera and Kazuyoshi Ikuta

    Biochem Biophys Res Commun, 365 (1), 164-169, 2008.
17. Borna disease virus RNA detected in Japanese macaques (Macaca fuscata).

    Katsuro Hagiwara, Yusuke Tsuge, Mitsuhiko Asakawa, Hajime Kabaya, Minoru Okamoto, Taku Miyasho, Hiroyuki Taniyama, Chiaki Ishihara, Juan Carlos de la Torre and Kazuyoshi Ikuta

    Primates, 49 (1), 57-64, 2008.
18. Prion removal by nanofiltration under different experimental conditions.

    Mikihiro Yunoki, Hiroyuki Tanaka, Takeru Urayama, Shinji Hattori, Masahiro Ohtani, Yuji Ohkubo, Yoshiyasu Kawabata, Yuuki Miyatake, Ayako Nanjo, Eiji Iwao, Masanori Morita, Elaine Wilson, Christine Maclean and Kazuyoshi Ikuta

    Biologicals, 36 (1), 27-36, 2008.

Link

http://www.biken.osaka-u.ac.jp/