Department of Oncogene Research

Subjects:

1. Functional analyses of the Src family tyrosine kinases (SFK) in neural development.
2. Structural biology of SFK signaling.
3. Studies on SFK signaling in C. elegans.
4. Studies of SFK signaling in cancer cells.

Published Papers

1. The lipid raft-anchored adaptor protein Cbp controls the oncogenic potential of c-Src.

   Chitose Oneyama, Tomoya Hikita, Kengo Enya, Marc-Werner Dobenecker, Kazunobu Saito, Shigeyuki Nada, Alexander Tarakhovsky and Masato Okada

   Mol Cell, 30 (4), 426-436, 2008.
2. Ablation of Csk in neural crest lineages causes corneal anomaly by deregulating collagen fibril organization and cell motility.

   Atsuko Takatsuka, Reiko Yagi, Masato Koike, Chitose Oneyama, Shigeyuki Nada, Christian Schmedt, Yasuo Uchiyama and Masato Okada

   Dev Biol, 315 (2), 474-488, 2008.
3. Functional dissection of transformation by c-Src and v-Src.

   Chitose Oneyama, Tomoya Hikita, Shigeyuki Nada and Masato Okada

   Genes Cells, 13 (1), 1-12, 2008.
4. Proteomic identification of ZO-1/2 as a novel scaffold for Src/Csk regulatory circuit.

   Kazunobu Saito, Kengo Enya, Chitose Oneyama, Tomoya Hikita and Masato Okada

   Biochem Biophys Res Commun, 366 (4), 969-975, 2008.
5. Structural insight into the specific interaction between murine SHPS-1/SIRP alpha and its ligand CD47.

   Aki Nakaishi, Mayumi Hirose, Masato Yoshimura, Chitose Oneyama, Kazunobu Saito, Nobuharu Kuki, Makoto Matsuda, Nakayuki Honma, Hiroshi Ohnishi, Takashi Matozaki, Masato Okada and Atsushi Nakagawa

   J Mol Biol, 375 (3), 650-660, 2008.

Link

http://www.biken.osaka-u.ac.jp/