Department of Molecular Virology

Subjects:

1. Studies on Hepatitis C virus.
2. Development of viral vectors.

Published Papers

1. Establishment of an infectious genotype 1b hepatitis C virus clone in human hepatocyte chimeric mice.

   Takashi Kimura, Michio Imamura, Nobuhiko Hiraga, Tsuyoshi Hatakeyama, Daiki Miki, Chiemi Noguchi, Nami Mori, Masataka Tsuge, Shoichi Takahashi, Yoshifumi Fujimoto, Eiji Iwao, Hidenori Ochi, Hiromi Abe, Toshiro Maekawa, Keiko Arataki, Chise Tateno, Katsutoshi Yoshizato, Takaji Wakita, Toru Okamoto, Yoshiharu Matsuura and Kazuaki Chayama

   J Gen Virol, 89 (Pt 9), 2108-2113, 2008.
2. Intramembrane Processing by Signal Peptide Peptidase Regulates the Membrane Localization of Hepatitis C Virus Core Protein and Viral Propagation.

   Kiyoko Okamoto, Yoshio Mori, Yasumasa Komoda, Toru Okamoto, Masayasu Okochi, Masatoshi Takeda, Tetsuro Suzuki, Kohji Moriishi and Yoshiharu Matsuura

   J Virol, 82 (17), 8349-8361, 2008.
3. Interaction of hepatitis C virus nonstructural protein 5A with core protein is critical for the production of infectious virus particles.

   Takahiro Masaki, Ryosuke Suzuki, Kyoko Murakami, Hideki Aizaki, Koji Ishii, Asako Murayama, Tomoko Date, Yoshiharu Matsuura, Tatsuo Miyamura, Takaji Wakita and Tetsuro Suzuki

   J Virol, 82 (16), 7964-7976, 2008.
4. Crystallization and preliminary X-ray diffraction analysis of recombinant hepatitis E virus-like particle.

   Che-Yen Wang, Naoyuki Miyazaki, Tetsuo Yamashita, Akifumi Higashiura, Atsushi Nakagawa, Tian-Cheng Li, Naokazu Takeda, Li Xing, Erik Hjalmarsson, Claes Friberg, Der-Ming Liou, Yen-Jen Sung, Tomitake Tsukihara, Yoshiharu Matsuura, Tatsuo Miyamura and R Holland Cheng

   Acta Crystallogr Sect F Struct Biol Cryst Commun, 64 (Pt 4), 318-322, 2008.
5. Baculovirus-mediated interferon alleviates dimethylnitrosamine-induced liver cirrhosis symptoms in a murine model.

   Y Nishibe, H Kaneko, H Suzuki, T Abe, Y Matsuura and H Takaku

   Gene Ther, 15 (13), 990-997, 2008.
6. Critical role of virion-associated cholesterol and sphingolipid in hepatitis C virus infection.

   Hideki Aizaki, Kenichi Morikawa, Masayoshi Fukasawa, Hiromichi Hara, Yasushi Inoue, Hideki Tani, Kyoko Saito, Masahiro Nishijima, Kentaro Hanada, Yoshiharu Matsuura, Michael M C Lai, Tatsuo Miyamura, Takaji Wakita and Tetsuro Suzuki

   J Virol, 82 (12), 5715-5724, 2008.
7. Hepatitis C virus core protein: Its coordinate roles with PA28gamma in metabolic abnormality and carcinogenicity in the liver.

   Yoshio Mori, Kohji Moriishi and Yoshiharu Matsuura

   Int J Biochem Cell Biol, 40 (8), 1437-1442, 2008.
8. A Single Amino Acid Mutation in Hepatitis C Virus NS5A Disrupting FKBP8 Interaction Impairs Viral Replication.

   Toru Okamoto, Hiroko Omori, Yuuki Kaname, Takayuki Abe, Yorihiro Nishimura, Tetsuro Suzuki, Tatsuo Miyamura, Tamotsu Yoshimori, Kohji Moriishi and Yoshiharu Matsuura

   J Virol, 82 (7), 3480-3489, 2008.
9. Crystal structure of the catalytic domain of Japanese encephalitis virus NS3 helicase/nucleoside triphosphatase at a resolution of 1.8 A.

   Tetsuo Yamashita, Hideaki Unno, Yoshio Mori, Hideki Tani, Kohji Moriishi, Akihisa Takamizawa, Masanobu Agoh, Tomitake Tsukihara and Yoshiharu Matsuura

   Virology, 373 (2), 426-436, 2008.
10. Human Butyrate-Induced Transcript 1 Interacts with Hepatitis C Virus NS5A and Regulates Viral Replication.

    Shuhei Taguwa, Toru Okamoto, Takayuki Abe, Yoshio Mori, Tetsuro Suzuki, Kohji Moriishi and Yoshiharu Matsuura

    J Virol, 82 (6), 2631-2641, 2008.

Link

http://www.biken.osaka-u.ac.jp/