Department of Molecular Genetics

Subjects:

1. Molecular mechanisms regulating the cell cycle in mammalian cells.
2. Molecular mechanisms controlling the meiosis in fission yeast.
3. Molecular mechanisms modulating the metastasis of malignant cells.
4. Application of a new technique (stepwise subtraction) to RNA diagnosis.

Published Papers

1. Lats2 is a negative regulator of myocyte size in the heart.

   Yutaka Matsui, Noritsugu Nakano, Dan Shao, Shumin Gao, Wenting Luo, Chull Hong, Peiyong Zhai, Eric Holle, Xianzhong Yu, Norikazu Yabuta, Wufan Tao, Thomas Wagner, Hiroshi Nojima and Junichi Sadoshima

   Circ Res, 103 (11), 1309-1318, 2008.
2. Chum-RNA allows preparation of a high-quality cDNA library from a single-cell quantity of mRNA without PCR amplification.

   Takahiro Tougan, Daisuke Okuzaki and Hiroshi Nojima

   Nucleic Acids Res, 36 (15), e92, 2008.
3. Expression profiling of PBMC-based diagnostic gene markers isolated from vasculitis patients.

   Shigeto Kobayashi, Akihiko Ito, Daisuke Okuzaki, Hiroaki Onda, Norikazu Yabuta, Ippei Nagamori, Kazuo Suzuki, Hiroshi Hashimoto and Hiroshi Nojima

   DNA Res, 15 (4), 253-265, 2008.
4. Mug27 is a meiosis-specific protein kinase that functions in fission yeast meiosis II and sporulation.

   Ayami Ohtaka, Daisuke Okuzaki and Hiroshi Nojima

   J Cell Sci, 121 (Pt 9), 1547-1558, 2008.
5. Overexpression of connexin 26 in carcinoma of the pancreas.

   Naganori Kyo, Hirofumi Yamamoto, Yutaka Takeda, Koji Ezumi, Chew Yee Ngan, Motokazu Terayama, Masakazu Miyake, Ichiro Takemasa, Masataka Ikeda, Yuichiro Doki, Keizo Dono, Mitsugu Sekimoto, Hiroshi Nojima and Morito Monden

   Oncol Rep, 19 (3), 627-631, 2008.
6. Focused microarray analysis of peripheral mononuclear blood cells from Churg-Strauss syndrome patients.

   Takahiro Tougan, Hiroaki Onda, Daisuke Okuzaki, Shigeto Kobayashi, Hiroshi Hashimoto and Hiroshi Nojima

   DNA Res, 15 (2), 103-114, 2008.
7. Aberrant Expression of Connexin 26 Is Associated with Lung Metastasis of Colorectal Cancer.

   Koji Ezumi, Hirofumi Yamamoto, Kohei Murata, Masahiko Higashiyama, Bazarragchaa Damdinsuren, Yurika Nakamura, Naganori Kyo, Jiro Okami, Chew Yee Ngan, Ichiro Takemasa, Masataka Ikeda, Mitsugu Sekimoto, Nariaki Matsuura, Hiroshi Nojima and Morito Monden

   Clin Cancer Res, 14 (3), 677-684, 2008.
8. PRDM14 suppresses expression of differentiation marker genes in human embryonic stem cells.

   Norihiro Tsuneyoshi, Tomoyuki Sumi, Hiroaki Onda, Hiroshi Nojima, Norio Nakatsuji and Hirofumi Suemori

   Biochem Biophys Res Commun, 367 (4), 899-905, 2008.

Link

http://www.biken.osaka-u.ac.jp/