Department of Immunoregulation

Subjects:

1. Biochemistry and molecular biology of biosynthesis pathway of GPI-anchored proteins.
2. Molecular pathogenesis of a GPI-anchor deficiencies, paroxysmal nocturnal hemoglobinuria and inherited GPI deficiency.
3. Roles of GPI in microorganisms.

Published Papers

1. Association of dengue virus NS1 protein with lipid rafts.

   Sansanee Noisakran, Thanyaporn Dechtawewat, Panisadee Avirutnan, Taroh Kinoshita, Uamporn Siripanyaphinyo, Chunya Puttikhunt, Watchara Kasinrerk, Prida Malasit and Nopporn Sittisombut

   J Gen Virol, 89 (Pt 10), 2492-2500, 2008.
2. GPHR is a novel anion channel critical for acidification and functions of the Golgi apparatus.

   Yusuke Maeda, Toru Ide, Masato Koike, Yasuo Uchiyama and Taroh Kinoshita

   Nat Cell Biol, 10 (10), 1135-1145, 2008.
3. Biosynthesis, remodelling and functions of mammalian GPI-anchored proteins: recent progress.

   Taroh Kinoshita, Morihisa Fujita and Yusuke Maeda

   J Biochem, 144 (3), 287-294, 2008.
4. Efficacy of recombinant bacille Calmette-Guérin vaccine secreting interleukin-15/antigen 85B fusion protein in providing protection against Mycobacterium tuberculosis.

   Ce Tang, Hisakata Yamada, Kensuke Shibata, Naoyoshi Maeda, Shinichi Yoshida, Worawidh Wajjwalku, Naoya Ohara, Takeshi Yamada, Taroh Kinoshita and Yasunobu Yoshikai

   J Infect Dis, 197 (9), 1263-1274, 2008.
5. Dolichol-phosphate mannose synthase: structure, function and regulation.

   Yusuke Maeda and Taroh Kinoshita

   Biochim Biophys Acta, 1780 (6), 861-868, 2008.
6. Abscisic acid controls calcium-dependent egress and development in Toxoplasma gondii.

   Kisaburo Nagamune, Leslie M Hicks, Blima Fux, Fabien Brossier, Eduardo N Chini and L David Sibley

   Nature, 451 (7175), 207-210, 2008.
7. Mammalian GPI-anchored proteins require p24 proteins for their efficient transport from the ER to the plasma membrane.

   Satoshi Takida, Yusuke Maeda and Taroh Kinoshita

   Biochem J, 409 (2), 555-562, 2008.

Link

http://www.biken.osaka-u.ac.jp/