Laboratory of Combined Research on Microbiology and Immunology(Hirata Group)

Department of Infectious Diseases Control;

Subjects:

1. Biochemical and in vivo studies of the roles of selectins and their ligands.
2. Mechanisms of immune cell migration to the skin and mucosa.

Published Papers

1. CD4+CD25+ regulatory T cells in the small intestinal lamina propria show an effector/memory phenotype.

   Zijin Guo, Myoung Ho Jang, Kazuhiro Otani, Zhongbin Bai, Eiji Umemoto, Masanori Matsumoto, Mika Nishiyama, Mikako Yamasaki, Satoshi Ueha, Kouji Matsushima, Takako Hirata and Masayuki Miyasaka

   Int Immunol, 20 (3), 307-315, 2008.
2. Identification of novel isoforms of mouse L-selectin with different carboxyl-terminal tails.

   Yuko Furukawa, Eiji Umemoto, Myoung Ho Jang, Kazuo Tohya, Masayuki Miyasaka and Takako Hirata

   J Biol Chem, 283 (18), 12112-12119, 2008.
3. Chondroitin sulfate E fragments enhance CD44 cleavage and CD44-dependent motility in tumor cells.

   Kazuki N Sugahara, Takako Hirata, Toshiyuki Tanaka, Shinji Ogino, Mitsuhiro Takeda, Hiroaki Terasawa, Ichio Shimada, Jun-ichi Tamura, Gerdy B ten Dam, Toin H van Kuppevelt and Masayuki Miyasaka

   Cancer Res, 68 (17), 7191-7199, 2008.
4. CD43 plays both antiadhesive and proadhesive roles in neutrophil rolling in a context-dependent manner.

   Masanori Matsumoto, Akiko Shigeta, Masayuki Miyasaka and Takako Hirata

   J Immunol, 181 (5), 3628-3635, 2008.
5. Nepmucin/CLM-9, an Ig domain-containing sialomucin in vascular endothelial cells, promotes lymphocyte transendothelial migration in vitro.

   Soojung Jin, Eiji Umemoto, Toshiyuki Tanaka, Yoshimitsu Shimomura, Kazuo Tohya, Keiji Kunizawa, Bo-Gie Yang, Myoung Ho Jang, Takako Hirata and Masayuki Miyasaka

   FEBS Lett, 582 (20), 3018-3024, 2008.
6. An L-selectin ligand distinct from P-selectin glycoprotein ligand-1 is expressed on endothelial cells and promotes neutrophil rolling in inflammation.

   Akiko Shigeta, Masanori Matsumoto, Thomas F Tedder, John B Lowe, Masayuki Miyasaka and Takako Hirata

   Blood, 112 (13), 4915-4923, 2008.

Link

http://www.biken.osaka-u.ac.jp/