Department of Cellular Regulation

Subjects:

1. Cell biological analysis on molecular mechanism of autophagy.
2. Elucidation of physiological role of autophagy.
3. Molecular dissection of endocytic pathway.

Published Papers

1. Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production.

   Tatsuya Saitoh, Naonobu Fujita, Myoung Ho Jang, Satoshi Uematsu, Bo-Gie Yang, Takashi Satoh, Hiroko Omori, Takeshi Noda, Naoki Yamamoto, Masaaki Komatsu, Keiji Tanaka, Taro Kawai, Tohru Tsujimura, Osamu Takeuchi, Tamotsu Yoshimori and Shizuo Akira

   Nature, 456 (7219), 264-268, 2008.
2. Nucleotide-Dependent Conformational Changes and Assembly of the AAA ATPase SKD1/VPS4B.

   Michio Inoue, Hironari Kamikubo, Mikio Kataoka, Ryuichi Kato, Tamotsu Yoshimori, Soichi Wakatsuki and Masato Kawasaki

   Traffic, 9 (12), 2180-2189, 2008.
3. An Atg4B Mutant Hampers the Lipidation of LC3 Paralogues and Causes Defects in Autophagosome Closure.

   Naonobu Fujita, Mitsuko Hayashi, Hiromi Fukumoto, Hiroko Omori, Akitsugu Yamamoto, Takeshi Noda and Tamotsu Yoshimori

   Mol Biol Cell, 19 (11), 4651-4659, 2008.
4. Autophagic control of listeria through intracellular innate immune recognition in drosophila.

   Tamaki Yano, Shizuka Mita, Hiroko Ohmori, Yoshiteru Oshima, Yukari Fujimoto, Ryu Ueda, Haruhiko Takada, William E Goldman, Koichi Fukase, Neal Silverman, Tamotsu Yoshimori and Shoichiro Kurata

   Nat Immunol, 9 (8), 908-916, 2008.
5. Ubc4/5 and c-Cbl Continue to Ubiquitinate EGF Receptor after Internalization to Facilitate Polyubiquitination and Degradation.

   Kyohei Umebayashi, Harald Stenmark and Tamotsu Yoshimori

   Mol Biol Cell, 19 (8), 3454-3462, 2008.
6. Toward unraveling membrane biogenesis in mammalian autophagy.

   Tamotsu Yoshimori and Takeshi Noda

   Curr Opin Cell Biol, 20 (4), 401-407, 2008.
7. Golgi-resident small GTPase Rab33B interacts with Atg16L and modulates autophagosome formation.

   Takashi Itoh, Naonobu Fujita, Eiko Kanno, Akitsugu Yamamoto, Tamotsu Yoshimori and Mitsunori Fukuda

   Mol Biol Cell, 19 (7), 2916-2925, 2008.
8. The Ubi brothers reunited.

   Takeshi Noda, Naonobu Fujita and Tamotsu Yoshimori

   Autophagy, 4 (4), 540-541, 2008.
9. Dynein-dependent Movement of Autophagosomes Mediates Efficient Encounters with Lysosomes.

   Shunsuke Kimura, Takeshi Noda and Tamotsu Yoshimori

   Cell Struct Funct, 33 (1), 109-122, 2008.
10. Functional analysis of alpha5beta1 integrin and lipid rafts in invasion of epithelial cells by Porphyromonas gingivalis using fluorescent beads coated with bacterial membrane vesicles.

    Kayoko Tsuda, Nobumichi Furuta, Hiroaki Inaba, Shinji Kawai, Kentaro Hanada, Tamotsu Yoshimori and Atsuo Amano

    Cell Struct Funct, 33 (1), 123-132, 2008.
11. The Atg16L Complex Specifies the Site of LC3 Lipidation for Membrane Biogenesis in Autophagy.

    Naonobu Fujita, Takashi Itoh, Mitsunori Fukuda, Takeshi Noda and Tamotsu Yoshimori

    Mol Biol Cell, 19 (5), 2092-2100, 2008.
12. GFP-like proteins stably accumulate in lysosomes.

    Hiroyuki Katayama, Akitsugu Yamamoto, Noboru Mizushima, Tamotsu Yoshimori and Atsushi Miyawaki

    Cell Struct Funct, 33 (1), 1-12, 2008.
13. Human RME-8 is involved in membrane trafficking through early endosomes.

    Akemi Fujibayashi, Tomohiko Taguchi, Ryo Misaki, Masashi Ohtani, Naoshi Dohmae, Koji Takio, Masashi Yamada, Jianguo Gu, Megumi Yamakami, Mitsunori Fukuda, Satoshi Waguri, Yasuo Uchiyama, Tamotsu Yoshimori and Kiyotoshi Sekiguchi

    Cell Struct Funct, 33 (1), 35-50, 2008.
14. A Single Amino Acid Mutation in Hepatitis C Virus NS5A Disrupting FKBP8 Interaction Impairs Viral Replication.

    Toru Okamoto, Hiroko Omori, Yuuki Kaname, Takayuki Abe, Yorihiro Nishimura, Tetsuro Suzuki, Tatsuo Miyamura, Tamotsu Yoshimori, Kohji Moriishi and Yoshiharu Matsuura

    J Virol, 82 (7), 3480-3489, 2008.
15. Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes.

    Daniel J Klionsky, Hagai Abeliovich, Patrizia Agostinis, Devendra K Agrawal, Gjumrakch Aliev, David S Askew, Misuzu Baba, Eric H Baehrecke, Ben A Bahr, Andrea Ballabio, Bruce A Bamber, Diane C Bassham, Ettore Bergamini, Xiaoning Bi, Martine Biard-Piechaczyk, Janice S Blum, Dale E Bredesen, Jeffrey L Brodsky, John H Brumell, Ulf T Brunk, Wilfried Bursch, Nadine Camougrand, Eduardo Cebollero, Francesco Cecconi, Yingyu Chen, Lih-Shen Chin, Augustine Choi, Charleen T Chu, Jongkyeong Chung, Peter G H Clarke, Robert S B Clark, Steven G Clarke, Corinne Clavé, John L Cleveland, Patrice Codogno, María I Colombo, Ana Coto-Montes, James M Cregg, Ana Maria Cuervo, Jayanta Debnath, Francesca Demarchi, Patrick B Dennis, Phillip A Dennis, Vojo Deretic, Rodney J Devenish, Federica Di Sano, J Fred Dice, Marian Difiglia, Savithramma Dinesh-Kumar, Clark W Distelhorst, Mojgan Djavaheri-Mergny, Frank C Dorsey, Wulf Dröge, Michel Dron, William A Dunn, Michael Duszenko, N Tony Eissa, Zvulun Elazar, Audrey Esclatine, Eeva-Liisa Eskelinen, László Fésüs, Kim D Finley, José M Fuentes, Juan Fueyo, Kozo Fujisaki, Brigitte Galliot, Fen-Biao Gao, David A Gewirtz, Spencer B Gibson, Antje Gohla, Alfred L Goldberg, Ramon Gonzalez, Cristina González-Estévez, Sharon Gorski, Roberta A Gottlieb, Dieter Häussinger, You-Wen He, Kim Heidenreich, Joseph A Hill, Maria Høyer-Hansen, Xun Hu, Wei-Pang Huang, Akiko Iwasaki, Marja Jäättelä, William T Jackson, Xuejun Jiang, Shengkan Jin, Terje Johansen, Jae U Jung, Motoni Kadowaki, Chanhee Kang, Ameeta Kelekar, David H Kessel, Jan A K W Kiel, Hong Pyo Kim, Adi Kimchi, Timothy J Kinsella, Kirill Kiselyov, Katsuhiko Kitamoto, Erwin Knecht, Masaaki Komatsu, Eiki Kominami, Seiji Kondo, Attila L Kovács, Guido Kroemer, Chia-Yi Kuan, Rakesh Kumar, Mondira Kundu, Jacques Landry, Marianne Laporte, Weidong Le, Huan-Yao Lei, Michael J Lenardo, Beth Levine, Andrew Lieberman, Kah-Leong Lim, Fu-Cheng Lin, Willisa Liou, Leroy F Liu, Gabriel Lopez-Berestein, Carlos López-Otín, Bo Lu, Kay F Macleod, Walter Malorni, Wim Martinet, Ken Matsuoka, Josef Mautner, Alfred J Meijer, Alicia Meléndez, Paul Michels, Giovanni Miotto, Wilhelm P Mistiaen, Noboru Mizushima, Baharia Mograbi, Iryna Monastyrska, Michael N Moore, Paula I Moreira, Yuji Moriyasu, Tomasz Motyl, Christian Münz, Leon O Murphy, Naweed I Naqvi, Thomas P Neufeld, Ichizo Nishino, Ralph A Nixon, Takeshi Noda, Bernd Nürnberg, Michinaga Ogawa, Nancy L Oleinick, Laura J Olsen, Bulent Ozpolat, Shoshana Paglin, Glen E Palmer, Issidora Papassideri, Miles Parkes, David H Perlmutter, George Perry, Mauro Piacentini, Ronit Pinkas-Kramarski, Mark Prescott, Tassula Proikas-Cezanne, Nina Raben, Abdelhaq Rami, Fulvio Reggiori, Bärbel Rohrer, David C Rubinsztein, Kevin M Ryan, Junichi Sadoshima, Hiroshi Sakagami, Yasuyoshi Sakai, Marco Sandri, Chihiro Sasakawa, Miklós Sass, Claudio Schneider, Per O Seglen, Oleksandr Seleverstov, Jeffrey Settleman, John J Shacka, Irving M Shapiro, Andrei Sibirny, Elaine C M Silva-Zacarin, Hans-Uwe Simon, Cristiano Simone, Anne Simonsen, Mark A Smith, Katharina Spanel-Borowski, Vickram Srinivas, Meredith Steeves, Harald Stenmark, Per E Stromhaug, Carlos S Subauste, Seiichiro Sugimoto, David Sulzer, Toshihiko Suzuki, Michele S Swanson, Ira Tabas, Fumihiko Takeshita, Nicholas J Talbot, Zsolt Tallóczy, Keiji Tanaka, Kozo Tanaka, Isei Tanida, Graham S Taylor, J Paul Taylor, Alexei Terman, Gianluca Tettamanti, Craig B Thompson, Michael Thumm, Aviva M Tolkovsky, Sharon A Tooze, Ray Truant, Lesya V Tumanovska, Yasuo Uchiyama, Takashi Ueno, Néstor L Uzcátegui, Ida van der Klei, Eva C Vaquero, Tibor Vellai, Michael W Vogel, Hong-Gang Wang, Paul Webster, John W Wiley, Zhijun Xi, Gutian Xiao, Joachim Yahalom, Jin-Ming Yang, George Yap, Xiao-Ming Yin, Tamotsu Yoshimori, Li Yu, Zhenyu Yue, Michisuke Yuzaki, Olga Zabirnyk, Xiaoxiang Zheng, Xiongwei Zhu and Russell L Deter

    Autophagy, 4 (2), 151-175, 2008.
16. Transport of phosphatidylinositol 3-phosphate into the vacuole via autophagic membranes in Saccharomyces cerevisiae.

    Keisuke Obara, Takeshi Noda, Kaori Niimi and Yoshinori Ohsumi

    Genes Cells, 13 (6), 537-547, 2008.

Link

http://www.biken.osaka-u.ac.jp/