Department of Viral Infections

Subjects:

1. Analysis of host genetic factors affecting disease courses of human immunodeficiency virus (HIV) infection.
2. Studies on chemokines and chemokine receptors.
3. Analysis of molecular mechanisms of HIV entry into target cells.
4. Analysis of molecular mechanisms of HIV virion formation.
5. Development of a novel vector system based on Sendai virus.

Published Papers

1. A three-base-deletion polymorphism in the upstream non-coding region of human interleukin 7 (IL-7) gene could enhance levels of IL-7 expression.

   H Song, E E Nakayama, S Likanonsakul, C Wasi, A Iwamoto and T Shioda

   Int J Immunogenet, 34 (2), 107-113, 2007.
2. The polymorphisms in DC-SIGNR affect susceptibility to HIV type 1 infection.

   Nuanjun Wichukchinda, Yoshihiro Kitamura, Archawin Rojanawiwat, Emi E Nakayama, Haihan Song, Panita Pathipvanich, Wattana Auwanit, Pathom Sawanpanyalert, Aikichi Iwamoto, Tatsuo Shioda and Koya Ariyoshi

   AIDS Res Hum Retroviruses, 23 (5), 686-692, 2007.
3. Anti-retroviral drug resistance-associated mutations among non-subtype B HIV-1-infected Kenyan children with treatment failure.

   Raphael Lwembe, Washingtone Ochieng, Annie Panikulam, Charles O Mongoina, Tresa Palakudy, Yusuke Koizumi, Seiji Kageyama, Naohiko Yamamoto, Tatsuo Shioda, Rachel Musoke, Mary Owens, Elijah M Songok, Frederick A Okoth and Hiroshi Ichimura

   J Med Virol, 79 (7), 865-872, 2007.
4. Retro-transduction by virus pseudotyped with glycoprotein of vesicular stomatitis virus.

   Masahisa Ohishi, Tatsuo Shioda and Jun-ichi Sakuragi

   Virology, 362 (1), 131-138, 2007.
5. RANTES -28G delays and DC-SIGN - 139C enhances AIDS progression in HIV type 1-infected Japanese hemophiliacs.

   Yusuke Koizumi, Seiji Kageyama, Yoshihide Fujiyama, Michiko Miyashita, Raphael Lwembe, Keiki Ogino, Tatsuo Shioda and Hiroshi Ichimura

   AIDS Res Hum Retroviruses, 23 (5), 713-719, 2007.
6. Wild type and H43Y variant of human TRIM5alpha show similar anti-human immunodeficiency virus type 1 activity both in vivo and in vitro.

   Emi E Nakayama, Wassila Carpentier, Dominique Costagliola, Tatsuo Shioda, Aikichi Iwamoto, Patrice Debre, Kazuhisa Yoshimura, Brigitte Autran, Shuzo Matsushita and Ioannis Theodorou

   Immunogenetics, 59 (6), 511-515, 2007.
7. A single amino acid of the human immunodeficiency virus type 2 capsid affects its replication in the presence of cynomolgus monkey and human TRIM5alphas.

   Haihan Song, Emi E Nakayama, Masaru Yokoyama, Hironori Sato, Jay A Levy and Tatsuo Shioda

   J Virol, 81 (13), 7280-7285, 2007.
8. Minimal region sufficient for genome dimerization in the human immunodeficiency virus type 1 virion and its potential roles in the early stages of viral replication.

   Jun-Ichi Sakuragi, Sayuri Sakuragi and Tatsuo Shioda

   J Virol, 81 (15), 7985-7992, 2007.
9. Potent inhibition of HIV-1 replication by novel non-peptidyl small molecule inhibitors of protease dimerization.

   Yasuhiro Koh, Shintaro Matsumi, Debananda Das, Masayuki Amano, David A Davis, Jianfeng Li, Sofiya Leschenko, Abigail Baldridge, Tatsuo Shioda, Robert Yarchoan, Arun K Ghosh and Hiroaki Mitsuya

   J Biol Chem, 282 (39), 28709-28720, 2007.
10. An EGR2/CITED1 transcription factor complex and the 14-3-3sigma tumor suppressor are involved in regulating ErbB2 expression in a transgenic-mouse model of human breast cancer.

    Rachelle L Dillon, Stephen T Brown, Chen Ling, Toshishiro Shioda and William J Muller

    Mol Cell Biol, 27 (24), 8648-8657, 2007.
11. Host genetic analysis of HIV type 1 subtype CRF01_AE (E)-infected Thai patients with different rates of disease progression.

    Suda Louisirirotchanakul, Ruengpung Sutthent, Chantapong Wasi, Thippawan Chuenchitra, Sorachai Nitayaphan, Arthur E Brown, Victoria R Polonis, Emi E Nakayama, Tatsuo Shioda, Huanliang Liu and Yutaka Takebe

    AIDS Res Hum Retroviruses, 23 (12), 1605-1608, 2007.
12. Polymorphisms in CCR5 chemokine receptor gene in Japan.

    H Liu, E E Nakayama, I Theodorou, Y Nagai, S Likanonsakul, C Wasi, P Debre, A Iwamoto and T Shioda

    Int J Immunogenet, 34 (5), 325-335, 2007.

Link

http://www.biken.osaka-u.ac.jp/