Department of Signal Transduction

Subjects:

1. Elucidation of the tube-forming mechanism by investigating the polarity of ECs.
2. Analysis of the functional role(s) of Tie2 and down stream of Tie2 in the maturation of blood vessels.
3. Analysis of hematopoietic cells in angiogenesis.
4. Analysis of specification between artery and vein.
5. Analysis of stem cell system in blood vessels.
6. Functional analysis of GINS complex and galectin-3 in stem cells.

Published Papers

1. A novel approach for myocardial regeneration with educated cord blood cells cocultured with cells from brown adipose tissue.

   Yoshihiro Yamada, Shin-ichiro Yokoyama, Noboru Fukuda, Hiroyasu Kidoya, Xiao-Yong Huang, Hisamichi Naitoh, Naoyuki Satoh and Nobuyuki Takakura

   Biochem Biophys Res Commun, 353 (1), 182-188, 2007.
2. Expression of angiogenic and neurotrophic factors in the progenitor cell niche of adult monkey subventricular zone.

   A B Tonchev, T Yamashima, J Guo, G N Chaldakov and N Takakura

   Neuroscience, 144 (4), 1425-1435, 2007.
3. Cardiac stem cells in brown adipose tissue express CD133 and induce bone marrow non-hematopoietic cells to differentiate into cardiomyocytes.

   Yoshihiro Yamada, Shin-Ichiro Yokoyama, Xiang-Di Wang, Noboru Fukuda and Nobuyuki Takakura

   Stem Cells, 25 (5), 1326-1333, 2007.
4. Essential roles of the CC chemokine ligand 3-CC chemokine receptor 5 axis in bleomycin-induced pulmonary fibrosis through regulation of macrophage and fibrocyte infiltration.

   Yuko Ishida, Akihiko Kimura, Toshikazu Kondo, Takahito Hayashi, Masaya Ueno, Nobuyuki Takakura, Kouji Matsushima and Naofumi Mukaida

   Am J Pathol, 170 (3), 843-854, 2007.
5. Inhibition of axonal outgrowth in the tumor environment: involvement of class 3 semaphorins.

   Ivan H Vachkov, Xiaoyong Huang, Yoshihiro Yamada, Anton B Tonchev, Tetsumori Yamashima, Satoru Kato and Nobuyuki Takakura

   Cancer Sci, 98 (8), 1192-1197, 2007.
6. Eplerenone attenuates myocardial fibrosis in the angiotensin II-induced hypertensive mouse: involvement of tenascin-C induced by aldosterone-mediated inflammation.

   Tomohiro Nishioka, Maiko Suzuki, Katsuya Onishi, Nobuyuki Takakura, Hiroyasu Inada, Toshimichi Yoshida, Michiaki Hiroe and Kyoko Imanaka-Yoshida

   J Cardiovasc Pharmacol, 49 (5), 261-268, 2007.
7. EphB4 overexpression in B16 melanoma cells affects arterial-venous patterning in tumor angiogenesis.

   Xiaoyong Huang, Yoshihiro Yamada, Hiroyasu Kidoya, Hisamichi Naito, Yumi Nagahama, Lingyu Kong, Shin-Ya Katoh, Weng-lin Li, Masaya Ueno and Nobuyuki Takakura

   Cancer Res, 67 (20), 9800-9808, 2007.
8. Neural-specific ablation of the scaffold protein JSAP1 in mice causes neonatal death.

   Asuka Iwanaga, Tokiharu Sato, Kazushi Sugihara, Atsushi Hirao, Nobuyuki Takakura, Hiroshi Okamoto, Masahide Asano and Katsuji Yoshioka

   Neurosci Lett, 429 (1), 43-48, 2007.

Link

http://www.biken.osaka-u.ac.jp/