Department of Molecular Virology

Subjects:

1. Studies on Hepatitis C virus.
2. Development of viral vectors.

Published Papers

1. Evaluation systems for anti-HCV drugs.

   Kohji Moriishi and Yoshiharu Matsuura

   Adv Drug Deliv Rev, 59 (12), 1213-1221, 2007.
2. Hepatitis C virus nonstructural protein 5A modulates the toll-like receptor-MyD88-dependent signaling pathway in macrophage cell lines.

   Takayuki Abe, Yuuki Kaname, Itsuki Hamamoto, Yoshimi Tsuda, Xiaoyu Wen, Shuhei Taguwa, Kohji Moriishi, Osamu Takeuchi, Taro Kawai, Tatsuya Kanto, Norio Hayashi, Shizuo Akira and Yoshiharu Matsuura

   J Virol, 81 (17), 8953-8966, 2007.
3. Host factors involved in the replication of hepatitis C virus.

   Kohji Moriishi and Yoshiharu Matsuura

   Rev Med Virol, 17 (5), 343-354, 2007.
4. Replication-competent recombinant vesicular stomatitis virus encoding hepatitis C virus envelope proteins.

   Hideki Tani, Yasumasa Komoda, Eiko Matsuo, Kensuke Suzuki, Itsuki Hamamoto, Tetsuo Yamashita, Kohji Moriishi, Kazuhito Fujiyama, Tatsuya Kanto, Norio Hayashi, Ania Owsianka, Arvind H Patel, Michael A Whitt and Yoshiharu Matsuura

   J Virol, 81 (16), 8601-8612, 2007.
5. Processing of capsid protein by cathepsin L plays a crucial role in replication of Japanese encephalitis virus in neural and macrophage cells.

   Yoshio Mori, Tetsuo Yamashita, Yoshinori Tanaka, Yoshimi Tsuda, Takayuki Abe, Kohji Moriishi and Yoshiharu Matsuura

   J Virol, 81 (16), 8477-8487, 2007.
6. Critical role of PA28γ in hepatitis C virus-associated steatogenesis and hepatocarcinogenesis.

   Kohji Moriishi, Rika Mochizuki, Kyoji Moriya, Hironobu Miyamoto, Yoshio Mori, Takayuki Abe, Shigeo Murata, Keiji Tanaka, Tatsuo Miyamura, Tetsuro Suzuki, Kazuhiko Koike and Yoshiharu Matsuura

   Proc Natl Acad Sci U S A, 104 (5), 1661-1666, 2007.
7. Involvement of PA28γ-Dependent Pathway in Insulin Resistance Induced by Hepatitis C Virus Core Protein.

   Hironobu Miyamoto, Kohji Moriishi, Kyoji Moriya, Shigeo Murata, Keiji Tanaka, Tetsuro Suzuki, Tatsuo Miyamura, Kazuhiko Koike and Yoshiharu Matsuura

   J Virol, 81 (4), 1727-1735, 2007.
8. E6AP Ubiquitin Ligase Mediates Ubiquitylation and Degradation of Hepatitis C Virus Core Protein.

   Masayuki Shirakura, Kyoko Murakami, Tohru Ichimura, Ryosuke Suzuki, Tetsu Shimoji, Kouichirou Fukuda, Katsutoshi Abe, Shigeko Sato, Masayoshi Fukasawa, Yoshio Yamakawa, Masahiro Nishijima, Kohji Moriishi, Yoshiharu Matsuura, Takaji Wakita, Tetsuro Suzuki, Peter M Howley, Tatsuo Miyamura and Ikuo Shoji

   J Virol, 81 (3), 1174-1185, 2007.

Link

http://www.biken.osaka-u.ac.jp/