Department of Molecular Protozoology

Subjects:

1. Development of a recombinant vaccine based on the malaria protein SERA.
2. Development of a novel vaccine adjuvant and elucidation of its mechanism of action.
3. Study on host-parasite interaction of malaria infection.
4. Study on phylogeny and evolution of SERA multigene family in the genus Plasmodium.

Published Papers

1. Manipulation of host innate immune responses by the malaria parasite.

   Cevayir Coban, Ken J Ishii, Toshihiro Horii and Shizuo Akira

   Trends Microbiol, 15 (6), 271-278, 2007.
2. Progress in the molecular biology of malaria and the immunology of nematode infections.

   Naoki Arizono, Kenji Nakanihsi, Toshihiro Horii and Kazuyuki Tanabe

   Trends Parasitol, 23 (4), 175-181, 2007.
3. Molecular Interaction of Ferredoxin and Ferredoxin-NADP+ Reductase from Human Malaria Parasite.

   Yoko Kimata-Ariga, Takashi Saitoh, Takahisa Ikegami, Toshihiro Horii and Toshiharu Hase

   J Biochem, 142 (6), 715-720, 2007.
4. Recent independent evolution of msp1 polymorphism in Plasmodium vivax and related simian malaria parasites.

   Kazuyuki Tanabe, Ananias Escalante, Naoko Sakihama, Masanori Honda, Nobuko Arisue, Toshihiro Horii, Richard Culleton, Toshiyuki Hayakawa, Tetsuo Hashimoto, Shirley Longacre, Sisira Pathirana, Shiroma Handunnetti and Hirohisa Kishino

   Mol Biochem Parasitol, 156 (1), 74-79, 2007.
5. Allelic dimorphism-associated restriction of recombination in Plasmodium falciparum msp1.

   Kazuyuki Tanabe, Naoko Sakihama, David Walliker, Hamza Babiker, Abdel-Muhsin A Abdel-Muhsin, Bernard Bakote'e, Hiroshi Ohmae, Nobuko Arisue, Toshihiro Horii, Ingegerd Rooth, Anna Färnert, Anders Björkman and Lisa Ranford-Cartwright

   Gene, 397 (1-2), 153-160, 2007.
6. Production of high-affinity human monoclonal antibody fab fragments to the 19-kilodalton C-terminal merozoite surface protein 1 of Plasmodium falciparum.

   Xun-Jia Cheng, Hitoshi Hayasaka, Katsuomi Watanabe, Yan-Lin Tao, Jin-Ye Liu, Hideo Tsukamoto, Toshihiro Horii, Kazuyuki Tanabe and Hiroshi Tachibana

   Infect Immun, 75 (7), 3614-3620, 2007.
7. Phylogeny and evolution of the SERA multigene family in the genus Plasmodium.

   Nobuko Arisue, Makoto Hirai, Meiji Arai, Hiroyuki Matsuoka and Toshihiro Horii

   J Mol Evol, 65 (1), 82-91, 2007.
8. Cloning and Characterization of Ferredoxin and Ferredoxin-NADP+ Reductase from Human Malaria Parasite.

   Yoko Kimata-Ariga, Genji Kurisu, Masami Kusunoki, Sayaka Aoki, Dan Sato, Tamaki Kobayashi, Kiyoshi Kita, Toshihiro Horii and Toshiharu Hase

   J Biochem (Tokyo), 141 (3), 421-428, 2007.
9. Pathological role of Toll-like receptor signaling in cerebral malaria.

   Cevayir Coban, Ken J Ishii, Satoshi Uematsu, Nobuko Arisue, Shintaro Sato, Masahiro Yamamoto, Taro Kawai, Osamu Takeuchi, Hajime Hisaeda, Toshihiro Horii and Shizuo Akira

   Int Immunol, 19 (1), 67-79, 2007.
10. Differential Role of TLR- and RLR-Signaling in the Immune Responses to Influenza A Virus Infection and Vaccination.

    Shohei Koyama, Ken J Ishii, Himanshu Kumar, Takeshi Tanimoto, Cevayir Coban, Satoshi Uematsu, Taro Kawai and Shizuo Akira

    J Immunol, 179 (7), 4711-4720, 2007.
11. Enhanced TLR-mediated NF-IL6 dependent gene expression by Trib1 deficiency.

    Masahiro Yamamoto, Satoshi Uematsu, Toru Okamoto, Yoshiharu Matsuura, Shintaro Sato, Himanshu Kumar, Takashi Satoh, Tatsuya Saitoh, Kiyoshi Takeda, Ken J Ishii, Osamu Takeuchi, Taro Kawai and Shizuo Akira

    J Exp Med, 204 (9), 2233-2239, 2007.
12. The Atg5 Atg12 conjugate associates with innate antiviral immune responses.

    Nao Jounai, Fumihiko Takeshita, Kouji Kobiyama, Asako Sawano, Atsushi Miyawaki, Ke-Qin Xin, Ken J Ishii, Taro Kawai, Shizuo Akira, Koichi Suzuki and Kenji Okuda

    Proc Natl Acad Sci U S A, 104 (35), 14050-14055, 2007.
13. Blocking of the TLR5 activation domain hampers protective potential of flagellin DNA vaccine.

    Sukumar Saha, Fumihiko Takeshita, Tomoko Matsuda, Nao Jounai, Kouji Kobiyama, Tetsuya Matsumoto, Shin Sasaki, Atsushi Yoshida, Ke-Qin Xin, Dennis M Klinman, Satoshi Uematsu, Ken J Ishii, Shizuo Akira and Kenji Okuda

    J Immunol, 179 (2), 1147-1154, 2007.
14. A polysaccharide carrier to effectively deliver native phosphodiester CpG DNA to antigen-presenting cells.

    Naohiko Shimada, Cevayir Coban, Yoichi Takeda, Masami Mizu, Jusaku Minari, Takahisa Anada, Yuichi Torii, Seiji Shinkai, Shizuo Akira, Ken J Ishii and Kazuo Sakurai

    Bioconjug Chem, 18 (4), 1280-1286, 2007.
15. Toll or toll-free adjuvant path toward the optimal vaccine development.

    Ken J Ishii and Shizuo Akira

    J Clin Immunol, 27 (4), 363-371, 2007.

Link

http://www.biken.osaka-u.ac.jp/