Department of Molecular Immunology

Subjects:

1. Molecular mechanisms involved in regulation of immune responses.
2. Mechanism of development of autoimmune diseases.
3. Molecular mechanism by which Epstein-Barr virus (EBV) causes B cell growth transformation and the modification of the differentiation.

Published Papers

1. Immune semaphorins: increasing members and their diverse roles.

   Hitoshi Kikutani, Kazuhiro Suzuki and Atsushi Kumanogoh

   Adv Immunol, 93, 121-143, 2007.
2. Semaphorin 7A initiates T-cell-mediated inflammatory responses through alpha1beta1 integrin.

   Kazuhiro Suzuki, Tatsusada Okuno, Midori Yamamoto, R Jeroen Pasterkamp, Noriko Takegahara, Hyota Takamatsu, Tomoe Kitao, Junichi Takagi, Paul D Rennert, Alex L Kolodkin, Atsushi Kumanogoh and Hitoshi Kikutani

   Nature, 446 (7136), 680-684, 2007.
3. Regulated surface expression and shedding support a dual role for semaphorin 4D in platelet responses to vascular injury.

   Li Zhu, Wolfgang Bergmeier, Jie Wu, Hong Jiang, Timothy J Stalker, Marcin Cieslak, Ran Fan, Laurence Boumsell, Atsushi Kumanogoh, Hitoshi Kikutani, Luca Tamagnone, Denisa D Wagner, Marcos E Milla and Lawrence F Brass

   Proc Natl Acad Sci U S A, 104 (5), 1621-1626, 2007.

Link

http://www.biken.osaka-u.ac.jp/